Detection and persistence of Zika virus in body fluids and associated factors: a prospective cohort study.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
06 Dec 2023
06 Dec 2023
Historique:
received:
08
10
2023
accepted:
27
11
2023
medline:
11
12
2023
pubmed:
7
12
2023
entrez:
6
12
2023
Statut:
epublish
Résumé
This study aimed to analyze the detection and duration of the Zika virus (ZIKV) in plasma, urine, saliva, sweat, rectal swabs, vaginal secretions, breast milk, and semen and to explore risk factors associated with prolonged viral persistence. A prospective cohort study of symptomatic patients and their household contacts was conducted in Brazil from July 2017 to June 2019. A total of 260 individuals (184 women and 76 men) with confirmed ZIKV infection were enrolled and followed up for 12 months. ZIKV RNA was present in all body fluid specimens and detectable for extended periods in urine, sweat, rectal swabs, and semen. The longest detection duration was found in semen, with high viral loads in the specimens. ZIKV RNA clearance was associated with several factors, including age, sex, education level, body mass index, non-purulent conjunctivitis, joint pain, and whether the participant had a history of yellow fever vaccination. The influence of each of these factors on the low or fast viral clearance varied according to the specific body fluid under investigation. Recurrent ZIKV detection events after total viral clearance were observed in the cohort. Our findings provide valuable insights into the persistence and potential recurrence of ZIKV infection, highlighting the need for continued monitoring and follow-up of individuals infected with ZIKV and for effective prevention measures to reduce the risk of transmission.
Identifiants
pubmed: 38057382
doi: 10.1038/s41598-023-48493-8
pii: 10.1038/s41598-023-48493-8
pmc: PMC10700488
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
21557Subventions
Organisme : World Health Organization
ID : Reference TSA1-2017/720873-0
Pays : International
Organisme : World Health Organization
ID : Reference TSA2-2017/731359-0
Pays : International
Organisme : Wellcome Trust
ID : Grant Number 206522/Z/17/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R21 AI139777
Pays : United States
Investigateurs
Morganna Costa Lima
(MC)
Informations de copyright
© 2023. The Author(s).
Références
Lancet Neurol. 2020 Oct;19(10):826-839
pubmed: 32949543
Euro Surveill. 2016 Jun 30;21(26):
pubmed: 27386894
J Med Virol. 2002 Dec;68(4):529-36
pubmed: 12376961
Emerg Infect Dis. 2016 Dec;22(12):2228-2230
pubmed: 27617352
J Family Med Prim Care. 2022 May;11(5):1890-1897
pubmed: 35800556
J Clin Virol. 2016 Sep;82:1-4
pubmed: 27389909
Annu Rev Pathol. 2023 Jan 24;18:181-203
pubmed: 36151059
J Infect Public Health. 2019 Sep - Oct;12(5):601-604
pubmed: 31129010
Lancet Infect Dis. 2016 Jun;16(6):653-660
pubmed: 26897108
Emerg Infect Dis. 2019 Apr;25(4):808-810
pubmed: 30882329
PLoS Negl Trop Dis. 2022 Oct 13;16(10):e0010727
pubmed: 36228027
J Med Virol. 2017 Jan;89(1):1-2
pubmed: 27671098
J Virol. 2021 May 24;95(12):
pubmed: 33789994
Lancet Infect Dis. 2020 Dec;20(12):1446-1456
pubmed: 32673593
Mem Inst Oswaldo Cruz. 2021 Jan 25;115:e200339
pubmed: 33503145
Paediatr Int Child Health. 2021 Feb;41(1):28-35
pubmed: 32576082
Lancet Infect Dis. 2016 Sep;16(9):1000-1001
pubmed: 27427201
Aging (Albany NY). 2020 Nov 20;12(22):22399-22404
pubmed: 33223506
Front Immunol. 2021 Aug 31;12:720952
pubmed: 34531867
Viruses. 2021 Jan 18;13(1):
pubmed: 33477428
Euro Surveill. 2016;21(10):30159
pubmed: 26987769
Lancet Infect Dis. 2020 Dec;20(12):1371
pubmed: 33248032
Lancet Infect Dis. 2017 Nov;17(11):1200-1208
pubmed: 28838639
Euro Surveill. 2016 Aug 11;21(32):
pubmed: 27541989
Lancet Infect Dis. 2016 Nov;16(11):1220
pubmed: 27788975
Viruses. 2022 Jun 02;14(6):
pubmed: 35746683
Infect Drug Resist. 2021 Jul 22;14:2823-2827
pubmed: 34326650
N Engl J Med. 2014 Dec 18;371(25):2394-401
pubmed: 25337633
BMC Infect Dis. 2018 Jan 22;18(1):49
pubmed: 29357841
Emerg Infect Dis. 2008 Aug;14(8):1232-9
pubmed: 18680646
Int Urol Nephrol. 2016 Dec;48(12):1961-1966
pubmed: 27567913
Endocrinology. 2020 Nov 1;161(11):
pubmed: 32880654
New Microbiol. 2018 Jan;41(1):30-33
pubmed: 29112766
MMWR Morb Mortal Wkly Rep. 2016 Jul 22;65(28):716-7
pubmed: 27442327
Curr Opin Infect Dis. 2016 Oct;29(5):459-66
pubmed: 27496713
PLoS Med. 2021 Feb 10;18(2):e1003273
pubmed: 33566817
Rev Inst Med Trop Sao Paulo. 2019;61:e19
pubmed: 30970110
J Infect Dis. 2019 Jan 1;219(1):31-40
pubmed: 30059980
N Engl J Med. 2018 Apr 12;378(15):1377-1385
pubmed: 29641964
PLoS Negl Trop Dis. 2017 Apr 10;11(4):e0005528
pubmed: 28394887
Emerg Infect Dis. 2019 May;25(5):951-954
pubmed: 31002058
Euro Surveill. 2016 Aug 11;21(32):
pubmed: 27542178
Trop Med Int Health. 2018 Jan;23(1):92-100
pubmed: 29194880
PLoS One. 2021 Jan 5;16(1):e0244981
pubmed: 33400705
Emerg Infect Dis. 2017 Aug;23(8):1274-1281
pubmed: 28548637
Emerg Infect Dis. 2019 Aug;25(8):1598-1600
pubmed: 31310210
N Engl J Med. 2022 Feb 24;386(8):757-767
pubmed: 35196428
PLoS Med. 2018 Jul 24;15(7):e1002611
pubmed: 30040845
Infection. 2022 Feb;50(1):149-156
pubmed: 34327616
Sci Total Environ. 2020 Aug 1;728:138812
pubmed: 32335406
Bull World Health Organ. 2017 Dec 01;95(12):802-809
pubmed: 29200521
N Engl J Med. 2017 Feb 14;379(13):1234-1243
pubmed: 28195756
Nat Rev Urol. 2019 Apr;16(4):211-230
pubmed: 30696994
Clin Infect Dis. 2017 Jan 1;64(1):107-109
pubmed: 27682065
Am J Trop Med Hyg. 2019 Jan;100(1):183-186
pubmed: 30398145
Emerg Infect Dis. 2017 May;23(5):863-865
pubmed: 28257281
Enferm Infecc Microbiol Clin (Engl Ed). 2018 Jan;36(1):21-23
pubmed: 28007310
Pathogens. 2022 Jul 29;11(8):
pubmed: 36014974
J Infect Dis. 2022 Sep 28;226(7):1140-1150
pubmed: 35924442
J Clin Lab Anal. 2021 Sep;35(9):e23923
pubmed: 34390043
PLoS Negl Trop Dis. 2021 Nov 4;15(11):e0009907
pubmed: 34735450
PLoS Negl Trop Dis. 2016 Jun 24;10(6):e0004816
pubmed: 27341420
Euro Surveill. 2017 Jan 19;22(3):
pubmed: 28128730
J Clin Virol. 2015 Jul;68:53-5
pubmed: 26071336
Clin Infect Dis. 2018 Apr 3;66(8):1173-1180
pubmed: 29300893
J Virol. 2022 Sep 28;96(18):e0121922
pubmed: 36040178
J Infect Dis. 2021 Nov 22;224(10):1756-1764
pubmed: 33822107
Bull World Health Organ. 2018 Jun 01;96(6):402-413D
pubmed: 29904223
Emerg Microbes Infect. 2018 Oct 17;7(1):169
pubmed: 30333476
Medicine (Baltimore). 2016 Apr;95(14):e3257
pubmed: 27057874
MMWR Morb Mortal Wkly Rep. 2016 Apr 15;65(14):372-4
pubmed: 27078057
Emerg Infect Dis. 2017 Jan;23(1):99-101
pubmed: 27748649
Lancet Glob Health. 2016 Oct;4(10):e736-43
pubmed: 27596037