Coagulation parameters correlate to venous thromboembolism occurrence during the perioperative period in patients with spinal fractures.
Coagulation
OR
ROC
Spinal injury surgery
Venous thromboembolism
Journal
Journal of orthopaedic surgery and research
ISSN: 1749-799X
Titre abrégé: J Orthop Surg Res
Pays: England
ID NLM: 101265112
Informations de publication
Date de publication:
06 Dec 2023
06 Dec 2023
Historique:
received:
23
10
2023
accepted:
25
11
2023
medline:
11
12
2023
pubmed:
7
12
2023
entrez:
7
12
2023
Statut:
epublish
Résumé
Venous thromboembolism (VTE) is one of the leading causes of mortality in hospitalized patients. However, whether the coagulation-related parameters of the hospitalized patients could be used to predict the occurrence of VTE in patients with spinal injury surgery remained unclear. The patients with spinal fractures who met the inclusion and exclusion criteria were enrolled to be analyzed using a retrospective analysis approach. The association of risk factors of enrolled patients and operations to VTE occurrence were analyzed. The activated partial thromboplastin time, prothrombin time, thrombin time, D-dimer (D-D), fibrinogen (FIB) and fibrinogen degradation products (FDP) were detected. ROC and HR analysis were applied to evaluate the correlation of coagulation-related parameters and other parameters to VTE occurrence. The indicators of D-D, FIB and FDP were significantly elevated in VTE patients compared to non-VTE patients. The multivariate analysis of OR showed that six risk factors, including age ≥ 60, spinal cord injury, postoperative bedtime over 5 days, plasma D-dimer ≥ 0.54 mg/L, plasma fibrinogen ≥ 3.75 g/L and plasma FDP ≥ 5.19 mg/L, were positively correlated to VTE. The six risk factors, including D-D, FIB, FDP, age ≥ 60, spinal cord injury, and postoperative bedtime over 5 days, could be used to predict the occurrence of VTE.
Sections du résumé
BACKGROUND
BACKGROUND
Venous thromboembolism (VTE) is one of the leading causes of mortality in hospitalized patients. However, whether the coagulation-related parameters of the hospitalized patients could be used to predict the occurrence of VTE in patients with spinal injury surgery remained unclear.
METHOD
METHODS
The patients with spinal fractures who met the inclusion and exclusion criteria were enrolled to be analyzed using a retrospective analysis approach. The association of risk factors of enrolled patients and operations to VTE occurrence were analyzed. The activated partial thromboplastin time, prothrombin time, thrombin time, D-dimer (D-D), fibrinogen (FIB) and fibrinogen degradation products (FDP) were detected. ROC and HR analysis were applied to evaluate the correlation of coagulation-related parameters and other parameters to VTE occurrence.
RESULT
RESULTS
The indicators of D-D, FIB and FDP were significantly elevated in VTE patients compared to non-VTE patients. The multivariate analysis of OR showed that six risk factors, including age ≥ 60, spinal cord injury, postoperative bedtime over 5 days, plasma D-dimer ≥ 0.54 mg/L, plasma fibrinogen ≥ 3.75 g/L and plasma FDP ≥ 5.19 mg/L, were positively correlated to VTE.
CONCLUSION
CONCLUSIONS
The six risk factors, including D-D, FIB, FDP, age ≥ 60, spinal cord injury, and postoperative bedtime over 5 days, could be used to predict the occurrence of VTE.
Identifiants
pubmed: 38057818
doi: 10.1186/s13018-023-04407-y
pii: 10.1186/s13018-023-04407-y
pmc: PMC10698905
doi:
Substances chimiques
Fibrin Fibrinogen Degradation Products
0
Fibrinogen
9001-32-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
928Informations de copyright
© 2023. The Author(s).
Références
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Feb 28;46(2):142-148
pubmed: 33678650
Spine (Phila Pa 1976). 2018 Sep 15;43(18):1289-1295
pubmed: 29538240
Front Cardiovasc Med. 2023 Feb 01;10:1003197
pubmed: 36818330
BMC Pregnancy Childbirth. 2023 Nov 11;23(1):788
pubmed: 37951881
Am J Health Syst Pharm. 2008 Oct 1;65(19):1825-9
pubmed: 18796423
JAMA Cardiol. 2019 Feb 1;4(2):163-173
pubmed: 30649175
Thromb Haemost. 2003 Sep;90(3):446-55
pubmed: 12958614
Am Heart J. 1987 Nov;114(5):1262-4
pubmed: 3673898
Cancer Biomark. 2018;21(4):909-913
pubmed: 29278886
Nat Rev Dis Primers. 2022 Feb 17;8(1):11
pubmed: 35177631
JAMA. 2021 Dec 7;326(21):2141-2149
pubmed: 34874418
Spine J. 2012 Nov;12(11):1029-34
pubmed: 23158967
J Yeungnam Med Sci. 2023 Nov;40(Suppl):S56-S64
pubmed: 37726959
Am J Manag Care. 2017 Dec;23(20 Suppl):S376-S382
pubmed: 29297660
Int J Angiol. 2023 Jan 13;32(4):243-247
pubmed: 37927846
Neurosurgery. 2017 May 1;80(5):787-792
pubmed: 28327952
J Clin Med. 2020 Aug 01;9(8):
pubmed: 32752154
Methods Mol Biol. 2017;1646:105-110
pubmed: 28804822
Joint Bone Spine. 2021 May;88(3):105122
pubmed: 33346109
Iran J Public Health. 2019 Apr;48(4):681-687
pubmed: 31110978
J Matern Fetal Neonatal Med. 2022 Aug;35(15):2995-2998
pubmed: 32928010
J Orthop Surg Res. 2020 Dec 10;15(1):597
pubmed: 33302974
Medicine (Baltimore). 2016 Dec;95(52):e5776
pubmed: 28033299
Clin Orthop Surg. 2014 Dec;6(4):468-75
pubmed: 25436073
Scand J Clin Lab Invest. 2018 Oct;78(6):439-442
pubmed: 29975107
Sci Rep. 2021 Jun 18;11(1):12868
pubmed: 34145330
Eur J Trauma Emerg Surg. 2020 Aug;46(4):913-917
pubmed: 30523360