NEXN Gene in Cardiomyopathies and Sudden Cardiac Deaths: Prevalence, Phenotypic Expression, and Prognosis.

dilated cardiomyopathy hypertrophic cardiomyopathy mutation phenotype prognosis

Journal

Circulation. Genomic and precision medicine
ISSN: 2574-8300
Titre abrégé: Circ Genom Precis Med
Pays: United States
ID NLM: 101714113

Informations de publication

Date de publication:
07 Dec 2023
Historique:
medline: 7 12 2023
pubmed: 7 12 2023
entrez: 7 12 2023
Statut: aheadofprint

Résumé

Few clinical data are available on DNA samples from consecutive patients with cardiomyopathy or sudden cardiac death/sudden infant death syndrome/idiopathic ventricular fibrillation were sequenced with a custom panel of genes. Index cases carrying at least one putative pathogenic variant in the Of the 9516 index patients sequenced, 31 were carriers of a putative pathogenic variant in Putative pathogenic

Sections du résumé

BACKGROUND UNASSIGNED
Few clinical data are available on
METHODS UNASSIGNED
DNA samples from consecutive patients with cardiomyopathy or sudden cardiac death/sudden infant death syndrome/idiopathic ventricular fibrillation were sequenced with a custom panel of genes. Index cases carrying at least one putative pathogenic variant in the
RESULTS UNASSIGNED
Of the 9516 index patients sequenced, 31 were carriers of a putative pathogenic variant in
CONCLUSIONS UNASSIGNED
Putative pathogenic

Identifiants

pubmed: 38059363
doi: 10.1161/CIRCGEN.123.004285
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e004285

Auteurs

Alexis Hermida (A)

Cardiology, Arrhythmia, and Cardiac Stimulation Service (A.H.), Amiens-Picardie University Hospital.
EA4666 HEMATIM, University of Picardie-Jules Verne, Amiens (A.H., G.J.).
Institute of Cardiology and ICAN Institute for Cardiometabolism and Nutrition (A.H., M. Laredo, P. Charron, E.G.).
Department of Genetics, Department of Cardiology, and Referral center for hereditary cardiac diseases, APHP, Pitié-Salpêtrière Hospital (A.H., P. Charron, E.G.).

Flavie Ader (F)

Unité Pédagogique de Biochimie, Département des Sciences Biologiques et Médicales, UFR de Pharmacie-Faculté de Santé, Université Paris Cité (F.A.).
Unité Fonctionnelle de Cardiogénétique et Myogénétique Moléculaire et Cellulaire, DMU Biogem, Service de Biochimie Métabolique, AP-HP-Sorbonne Université, Pitié-Salpêtrière -Charles Foix (F.A., P.R.).
Sorbonne Université, INSERM 1166, Paris (F.A., M. Laredo, P.R., P. Charron, E.G.).

Gilles Millat (G)

Service de Génétique Moléculaire, Hospices Civils de Lyon (G.M., A.J.).

Guillaume Jedraszak (G)

Molecular Genetics Laboratory (G.J.), Amiens-Picardie University Hospital.
EA4666 HEMATIM, University of Picardie-Jules Verne, Amiens (A.H., G.J.).

Phillipe Maury (P)

Service de Cardiologie (P.M.), CHU Toulouse.

Romain Cador (R)

Service de Cardiologie, Hôpital Saint Joseph, Paris (R.C.).

Pierre Antoine Catalan (P)

Service de Cardiologie, CHU Clermont Ferrand (P.A.C., R.E.).

Gaël Clerici (G)

Service de Cardiologie, Centre hospitalier universitaire, Saint Pierre, La Réunion (G.C.).

Nicolas Combes (N)

Service de Cardiologie, Clinique Pasteur, Toulouse (N.C.).

Pascal De Groote (P)

France CHU Lille, Service de Cardiologie & Inserm U1167, Institut Pasteur de Lille (P.D.G.).

Delphine Dupin-Deguine (D)

Service de Génétique (D.D.-D.), CHU Toulouse.

Romain Eschalier (R)

Service de Cardiologie, CHU Clermont Ferrand (P.A.C., R.E.).

Laurence Faivre (L)

Centre de Génétique, CHU Dijon (L.F.).

Patricia Garcia (P)

Unité Mort Inattendue du Nourrisson, Hôpital de la Conception, APHM, Marseille (P.G.).

Benoit Guillon (B)

Service de Cardiologie, CHU Besançon (B.G.).

Alexandre Janin (A)

Service de Génétique Moléculaire, Hospices Civils de Lyon (G.M., A.J.).

Beatrice Kugener (B)

Urgences Pédiatriques (B.K.), Hôpital Louis Pradel, HCL, Lyon.

Marylin Lackmy (M)

Unité de Génétique Clinique, CHU de Guadeloupe, Pointe à Pitre (M. Lackmy).

Mikael Laredo (M)

Institute of Cardiology and ICAN Institute for Cardiometabolism and Nutrition (A.H., M. Laredo, P. Charron, E.G.).
Sorbonne Université, INSERM 1166, Paris (F.A., M. Laredo, P.R., P. Charron, E.G.).

Xavier Le Guillou (X)

Service de Génétique Clinique, CHU Poitiers, Poitiers (X.L.G.).

François Lesaffre (F)

Service de Cardiologie, CHU Reims (F.L.).

Hugues Lucron (H)

Service de Cardiologie pédiatrique, CHU Martinique, Fort-de-France (H.L.).

Antoine Milhem (A)

Service de Cardiologie, CH La Rochelle (A.M.).

Gwenaël Nadeau (G)

Service de génétique clinique CH Métropole Savoie, Chambéry (G.N.).

Karine Nguyen (K)

Service de Génétique, APHM, Marseille (K.N.).

Aurélien Palmyre (A)

APHP, Ambroise Paré Hospital, Department of Genetics and Referral center for cardiac hereditary cardiac diseases, Boulogne-Billancourt (A.P., P. Charron).

Elodie Perdreau (E)

Département médico chirurgical de cardiologie pédiatrique (E.P.), Hôpital Louis Pradel, HCL, Lyon.

François Picard (F)

Service de Cardiologie, Hôpital Cardiologique Haut Leveque, Bordeaux (F.P.).

Nicolas Rebotier (N)

Service de Cardiologie, CH Basse-Terre (N.R.).

Pascale Richard (P)

Unité Fonctionnelle de Cardiogénétique et Myogénétique Moléculaire et Cellulaire, DMU Biogem, Service de Biochimie Métabolique, AP-HP-Sorbonne Université, Pitié-Salpêtrière -Charles Foix (F.A., P.R.).
Sorbonne Université, INSERM 1166, Paris (F.A., M. Laredo, P.R., P. Charron, E.G.).

Caroline Rooryck (C)

CHU Bordeaux, Service de Génétique Médicale (C.R.).

Julien Seitz (J)

Service de Cardiologie, Hôpital Saint Joseph, Marseille (J.S.).

Alain Verloes (A)

Departement de génétique, Hôpital Robert Debré, APHP (A. Verloes).

Agathe Vernier (A)

Service de Cardiologie, CH Compiègne (A. Vernier).

Pierre Winum (P)

Service de Cardiologie, CHU Nîmes (P.W.).

Grace-A-Dieu Yabeta (GA)

Service de Cardiologie, CH Ouest Guyane, Saint-Laurent-du-Maroni (G.-A.-D.Y.).

Océane Bouchot (O)

Service de Cardiologie, CH Annecy Genevois, Annecy, France (O.B.).

Philippe Chevalier (P)

Service de Cardiologie (P. Chevalier), Hôpital Louis Pradel, HCL, Lyon.

Philippe Charron (P)

Institute of Cardiology and ICAN Institute for Cardiometabolism and Nutrition (A.H., M. Laredo, P. Charron, E.G.).
Department of Genetics, Department of Cardiology, and Referral center for hereditary cardiac diseases, APHP, Pitié-Salpêtrière Hospital (A.H., P. Charron, E.G.).
Sorbonne Université, INSERM 1166, Paris (F.A., M. Laredo, P.R., P. Charron, E.G.).
APHP, Ambroise Paré Hospital, Department of Genetics and Referral center for cardiac hereditary cardiac diseases, Boulogne-Billancourt (A.P., P. Charron).

Estelle Gandjbakhch (E)

Institute of Cardiology and ICAN Institute for Cardiometabolism and Nutrition (A.H., M. Laredo, P. Charron, E.G.).
Department of Genetics, Department of Cardiology, and Referral center for hereditary cardiac diseases, APHP, Pitié-Salpêtrière Hospital (A.H., P. Charron, E.G.).
Sorbonne Université, INSERM 1166, Paris (F.A., M. Laredo, P.R., P. Charron, E.G.).

Classifications MeSH