Biophysical characterization of the Plasmodium falciparum circumsporozoite protein's N-terminal domain.

Circumsporozoite protein Plasmodium falciparum biophysics intrinsic disorder recombinant protein production and purification structural biology

Journal

Protein science : a publication of the Protein Society
ISSN: 1469-896X
Titre abrégé: Protein Sci
Pays: United States
ID NLM: 9211750

Informations de publication

Date de publication:
07 Dec 2023
Historique:
revised: 28 11 2023
received: 26 04 2023
accepted: 04 12 2023
medline: 7 12 2023
pubmed: 7 12 2023
entrez: 7 12 2023
Statut: aheadofprint

Résumé

The circumsporozoite protein (CSP) is the main surface antigen of the Plasmodium sporozoite (SPZ) and forms the basis of the currently only licensed anti-malarial vaccine (RTS,S/AS01). CSP uniformly coats the SPZ and plays a pivotal role in its immunobiology, in both the insect and the vertebrate hosts. Although CSP's N-terminal domain (CSP

Identifiants

DOI: 10.1002/pro.4852 PMID: 38059674
pubmed: 38059674
doi: 10.1002/pro.4852
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e4852

Informations de copyright

This article is protected by copyright. All rights reserved.

Auteurs

Rob Geens (R)

Laboratory of Medical Biochemistry (LMB), University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, 2610, Antwerp, Belgium.
Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium.

Jessica Stanisich (J)

Cellular and Molecular Immunology, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium.

Olivier Beyens (O)

Laboratory of Medicinal Chemistry (UAMC), University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, 2610, Antwerp, Belgium.

Stijn D'Hondt (S)

Laboratory of Medicinal Chemistry (UAMC), University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, 2610, Antwerp, Belgium.

Jean-Michel Thiberge (JM)

Unit of Malaria Infection & Immunity, Institut Pasteur, Rue du Docteur Roux 25-28, 75015, Paris, France.

Amber Ryckebosch (A)

Laboratory of Medical Biochemistry (LMB), University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, 2610, Antwerp, Belgium.

Anke De Groot (A)

Laboratory of Medical Biochemistry (LMB), University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, 2610, Antwerp, Belgium.

Stefan Magez (S)

Cellular and Molecular Immunology, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium.
Ghent University Global Campus, Songdomunhwa-Ro 119, Yeonsu-Gu, 406-840, Incheon, South Korea.

Didier Vertommen (D)

de Duve Institute and MASSPROT platform, UCLouvain, Hippokrateslaan 75, 1200, Brussels, Belgium.

Rogerio Amino (R)

Unit of Malaria Infection & Immunity, Institut Pasteur, Rue du Docteur Roux 25-28, 75015, Paris, France.

Hans De Winter (H)

Laboratory of Medicinal Chemistry (UAMC), University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, 2610, Antwerp, Belgium.

Alexander N Volkov (AN)

Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium.
VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), Pleinlaan 2, 1050, Brussels, Belgium.
Jean Jeener NMR Centre, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium.

Peter Tompa (P)

Structural Biology Brussels, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium.
VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), Pleinlaan 2, 1050, Brussels, Belgium.
Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Magyar tudósok körútja 2, 1117, Budapest, Hungary.
ORCID: 0000-0001-8042-9939

Yann G-J Sterckx (YG)

Laboratory of Medical Biochemistry (LMB), University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, 2610, Antwerp, Belgium.
ORCID: 0000-0002-7420-0983

Classifications MeSH