Polygenic risk of mental disorders and subject-specific school grades.

Educational attainment Polygenic risk scores language mathematics mental disorders school performance

Journal

Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264

Informations de publication

Date de publication:
05 Dec 2023
Historique:
received: 16 06 2023
revised: 04 11 2023
accepted: 18 11 2023
medline: 8 12 2023
pubmed: 8 12 2023
entrez: 7 12 2023
Statut: aheadofprint

Résumé

Education is essential for socioeconomic security and long-term mental health, however mental disorders are often detrimental to the educational trajectory. Genetic correlations between mental disorders and educational attainment do not always align with corresponding phenotypic associations, implying heterogeneity in the genetic overlap. We unraveled this heterogeneity by investigating associations between polygenic risk scores for six mental disorders and fine-grained school outcomes: school grades in language and mathematics in ninth grade and high school, as well as educational attainment by age 25, using nationwide-representative data from established cohorts (n = 79,489). High polygenic liability of attention-deficit hyperactivity-disorder was associated with lower grades in language and mathematics, whereas high polygenic risk of anorexia nervosa or bipolar disorder was associated with higher grades in language and mathematics. Associations between polygenic risk and school grades were mixed for schizophrenia and major depressive disorder, and neutral for autism spectrum disorder. Polygenic risk scores for mental disorders are differentially associated with language and mathematics school grades.

Sections du résumé

BACKGROUND BACKGROUND
Education is essential for socioeconomic security and long-term mental health, however mental disorders are often detrimental to the educational trajectory. Genetic correlations between mental disorders and educational attainment do not always align with corresponding phenotypic associations, implying heterogeneity in the genetic overlap.
METHODS METHODS
We unraveled this heterogeneity by investigating associations between polygenic risk scores for six mental disorders and fine-grained school outcomes: school grades in language and mathematics in ninth grade and high school, as well as educational attainment by age 25, using nationwide-representative data from established cohorts (n = 79,489).
RESULTS RESULTS
High polygenic liability of attention-deficit hyperactivity-disorder was associated with lower grades in language and mathematics, whereas high polygenic risk of anorexia nervosa or bipolar disorder was associated with higher grades in language and mathematics. Associations between polygenic risk and school grades were mixed for schizophrenia and major depressive disorder, and neutral for autism spectrum disorder.
CONCLUSIONS CONCLUSIONS
Polygenic risk scores for mental disorders are differentially associated with language and mathematics school grades.

Identifiants

DOI: 10.1016/j.biopsych.2023.11.020 PMID: 38061465
pubmed: 38061465
pii: S0006-3223(23)01749-3
doi: 10.1016/j.biopsych.2023.11.020
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2023. Published by Elsevier Inc.

Auteurs

Oskar Hougaard Jefsen (OH)

Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Aarhus, Denmark; Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address: oskar.jefsen@clin.au.dk.

Katrine Holde (K)

National Centre for Register-based Research, Aarhus University, Aarhus, Denmark.

John J McGrath (JJ)

National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; Queensland Centre for Mental Health Research, Wacol, QLD, Australia; Queensland Brain Institute, University of Queensland, St. Lucia, QLD, Australia.

Veera Manikandan Rajagopal (VM)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark; Center for Genomics and Personalized Medicine, Aarhus, Denmark; Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.

Clara Albiñana (C)

National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.

Bjarni Jóhann Vilhjálmsson (BJ)

National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.

Jakob Grove (J)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark; Center for Genomics and Personalized Medicine, Aarhus, Denmark; Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.

Esben Agerbo (E)

National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark; Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark; Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark.

Zeynep Yilmaz (Z)

National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Oleguer Plana-Ripoll (O)

Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Olof Palmes Allé 43-45, Aarhus, Denmark.

Trine Munk-Olsen (T)

National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark; Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark.

Ditte Demontis (D)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark; Center for Genomics and Personalized Medicine, Aarhus, Denmark.

Anders Børglum (A)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark; Center for Genomics and Personalized Medicine, Aarhus, Denmark; Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.

Ole Mors (O)

Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Aarhus, Denmark.

Cynthia M Bulik (CM)

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, USA.

Preben Bo Mortensen (PB)

National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.

Liselotte Vogdrup Petersen (LV)

National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.

Classifications MeSH