Analysis of immunophenotypic features in hyaline vascular type Castleman disease.
BCL2
CD21
CD3
Hyaline vascular type Castleman Disease
Immunophenotypic features
Journal
Diagnostic pathology
ISSN: 1746-1596
Titre abrégé: Diagn Pathol
Pays: England
ID NLM: 101251558
Informations de publication
Date de publication:
07 Dec 2023
07 Dec 2023
Historique:
received:
05
04
2023
accepted:
24
11
2023
medline:
8
12
2023
pubmed:
8
12
2023
entrez:
8
12
2023
Statut:
epublish
Résumé
Studies suggested that the immunophenotype of hyaline vascular type Castleman disease (HVCD) lacked characteristics, which was easy to be confused with other diseases. From January 2010 to June 2022, 17 cases of HVCD were selected from the Department of Pathology of Shaanxi Provincial People's Hospital and the Department of Pathology of Shaanxi Provincial Cancer Hospital. 13 cases of reactive hyperplastic lymph nodes (RHL) and 11 cases of follicular lymphoma (FL) were selected as the control group. All cases were performed CD3, CD20, CD21 and BCL2 immunohistochemical staining. (i) In 17 cases of HVCD, the negative area of BCL2 of germinal center was significantly smaller than the negative area of CD3 of germinal center. However, in 13 cases of RHL, the negative area of CD3 of germinal center was basically consistent with the negative area of germinal center of BCL2 of germinal center. In 11 cases of FL, in neoplastic follicles, the negative area of CD3 was basically consistent with the positive area of BCL2. The difference between HVCD group and other two groups of diseases was statistically significant (P < 0.05). (ii) In 17 cases of HVCD, the negative area of BCL2 of germinal center was significantly smaller than the follicular dendritic cell (FDC) meshworks expressed by CD21. However, in 13 cases of RHL, the FDC meshworks expressed by CD21 were basically consistent with the negative area of BCL2 of germinal center. In 11 cases of FL, in neoplastic follicles, the FDC meshworks expressed by CD21 was basically consistent with the positive area of BCL2. The difference between HVCD group and other two groups of disease was statistically significant (P < 0.05). HVCD has unique immunophenotypic characteristics. The negative area of BCL2 of germinal center is significantly smaller than the negative area of CD3. The negative area of the BCL2 of germinal center is significantly smaller than the FDC meshworks expressed by CD21. These two immunophenotypic features in HVCD are very important in diagnosis and differential diagnosis.
Sections du résumé
BACKGROUND
BACKGROUND
Studies suggested that the immunophenotype of hyaline vascular type Castleman disease (HVCD) lacked characteristics, which was easy to be confused with other diseases.
METHODS
METHODS
From January 2010 to June 2022, 17 cases of HVCD were selected from the Department of Pathology of Shaanxi Provincial People's Hospital and the Department of Pathology of Shaanxi Provincial Cancer Hospital. 13 cases of reactive hyperplastic lymph nodes (RHL) and 11 cases of follicular lymphoma (FL) were selected as the control group. All cases were performed CD3, CD20, CD21 and BCL2 immunohistochemical staining.
RESULTS
RESULTS
(i) In 17 cases of HVCD, the negative area of BCL2 of germinal center was significantly smaller than the negative area of CD3 of germinal center. However, in 13 cases of RHL, the negative area of CD3 of germinal center was basically consistent with the negative area of germinal center of BCL2 of germinal center. In 11 cases of FL, in neoplastic follicles, the negative area of CD3 was basically consistent with the positive area of BCL2. The difference between HVCD group and other two groups of diseases was statistically significant (P < 0.05). (ii) In 17 cases of HVCD, the negative area of BCL2 of germinal center was significantly smaller than the follicular dendritic cell (FDC) meshworks expressed by CD21. However, in 13 cases of RHL, the FDC meshworks expressed by CD21 were basically consistent with the negative area of BCL2 of germinal center. In 11 cases of FL, in neoplastic follicles, the FDC meshworks expressed by CD21 was basically consistent with the positive area of BCL2. The difference between HVCD group and other two groups of disease was statistically significant (P < 0.05).
CONCLUSIONS
CONCLUSIONS
HVCD has unique immunophenotypic characteristics. The negative area of BCL2 of germinal center is significantly smaller than the negative area of CD3. The negative area of the BCL2 of germinal center is significantly smaller than the FDC meshworks expressed by CD21. These two immunophenotypic features in HVCD are very important in diagnosis and differential diagnosis.
Identifiants
pubmed: 38062501
doi: 10.1186/s13000-023-01421-w
pii: 10.1186/s13000-023-01421-w
pmc: PMC10702065
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
132Subventions
Organisme : Key Research and Development Projects of Shaanxi Province
ID : No2023-YBSF-668
Organisme : Key Research and Development Projects of Shaanxi Province
ID : No2023-YBSF-668
Organisme : Key Research and Development Projects of Shaanxi Province
ID : No2023-YBSF-668
Organisme : Key Research and Development Projects of Shaanxi Province
ID : No2023-YBSF-668
Organisme : the Innovation team of Department of Science and Technology of Shaanxi Province No2020TD-048, ShaanXi Provincial People's Hospital
ID : No2021LJ-12
Organisme : the Innovation team of Department of Science and Technology of Shaanxi Province No2020TD-048, ShaanXi Provincial People's Hospital
ID : No2021LJ-12
Organisme : the Innovation team of Department of Science and Technology of Shaanxi Province No2020TD-048, ShaanXi Provincial People's Hospital
ID : No2021LJ-12
Organisme : the Innovation team of Department of Science and Technology of Shaanxi Province No2020TD-048, ShaanXi Provincial People's Hospital
ID : No2021LJ-12
Informations de copyright
© 2023. The Author(s).
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