Structural basis of substrate progression through the bacterial chaperonin cycle.

CryoEM Rubisco chaperonins protein folding

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
12 Dec 2023
Historique:
medline: 8 12 2023
pubmed: 8 12 2023
entrez: 8 12 2023
Statut: ppublish

Résumé

The bacterial chaperonin GroEL-GroES promotes protein folding through ATP-regulated cycles of substrate protein binding, encapsulation, and release. Here, we have used cryoEM to determine structures of GroEL, GroEL-ADP·BeF

Identifiants

pubmed: 38064510
doi: 10.1073/pnas.2308933120
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2308933120

Subventions

Organisme : UKRI | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/M009513/1
Organisme : Wellcome Trust (WT)
ID : 202679/Z/16/Z
Organisme : Wellcome Trust (WT)
ID : 206166/Z/17/Z

Déclaration de conflit d'intérêts

Competing interests statement:M.C.D. was an employee of SPT Labtech, the company that manufactures Chameleon systems.

Auteurs

Scott Gardner (S)

Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, London WC1E 7HX, United Kingdom.

Michele C Darrow (MC)

SPT Labtech, Melbourn, Cambridge SG8 6HB, United Kingdom.

Natalya Lukoyanova (N)

Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, London WC1E 7HX, United Kingdom.

Konstantinos Thalassinos (K)

Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, London WC1E 7HX, United Kingdom.
Division of Biosciences, Institute of Structural and Molecular Biology, University College London, London WC1E 6BT, United Kingdom.

Helen R Saibil (HR)

Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, London WC1E 7HX, United Kingdom.

Classifications MeSH