Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles.
Basement membrane thickening
ME/CFS
Microangiopathy
Post-COVID syndrome
Post-acute sequelae of COVID-19 (PASC)
Post-infectious syndrome
SARS-CoV-2
Journal
Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673
Informations de publication
Date de publication:
08 Dec 2023
08 Dec 2023
Historique:
received:
26
09
2023
accepted:
29
09
2023
medline:
9
12
2023
pubmed:
9
12
2023
entrez:
9
12
2023
Statut:
epublish
Résumé
The SARS-CoV-2 pandemic not only resulted in millions of acute infections worldwide, but also in many cases of post-infectious syndromes, colloquially referred to as "long COVID". Due to the heterogeneous nature of symptoms and scarcity of available tissue samples, little is known about the underlying mechanisms. We present an in-depth analysis of skeletal muscle biopsies obtained from eleven patients suffering from enduring fatigue and post-exertional malaise after an infection with SARS-CoV-2. Compared to two independent historical control cohorts, patients with post-COVID exertion intolerance had fewer capillaries, thicker capillary basement membranes and increased numbers of CD169
Identifiants
pubmed: 38066589
doi: 10.1186/s40478-023-01662-2
pii: 10.1186/s40478-023-01662-2
pmc: PMC10704838
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
193Subventions
Organisme : Helmholtz association Initiative and Networking Fund grant
ID : KA1-Co-02 'COVIPA'
Organisme : Helmholtz association Initiative and Networking Fund grant
ID : KA1-Co-02 'COVIPA'
Organisme : Helmholtz Association Initiative and Networking Fund grant
ID : KA1-Co-02 'COVIPA'
Informations de copyright
© 2023. The Author(s).
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