RhoA Is a Crucial Regulator of Myoblast Fusion.
adult muscle stem cells
muscle cell fusion
muscle damage
muscle hypertrophy
muscle regeneration
small GTPase proteins
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
21 Nov 2023
21 Nov 2023
Historique:
received:
24
10
2023
revised:
14
11
2023
accepted:
15
11
2023
medline:
9
12
2023
pubmed:
9
12
2023
entrez:
9
12
2023
Statut:
epublish
Résumé
Satellite cells (SCs) are adult muscle stem cells that are mobilized when muscle homeostasis is perturbed. Here we show that RhoA in SCs is indispensable to have correct muscle regeneration and hypertrophy. In particular, the absence of RhoA in SCs prevents a correct SC fusion both to other RhoA-deleted SCs (regeneration context) and to growing control myofibers (hypertrophy context). We demonstrated that RhoA is dispensable for SCs proliferation and differentiation; however, RhoA-deleted SCs have an inefficient movement even if their cytoskeleton assembly is not altered. Proliferative myoblast and differentiated myotubes without RhoA display a decreased expression of
Identifiants
pubmed: 38067102
pii: cells12232673
doi: 10.3390/cells12232673
pmc: PMC10705320
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : French Muscular Dystrophy Association
ID : 22365 and 22776
Organisme : IdEx Emergence Université de Paris
ID : IP 2019-030
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