Wnt/β-Catenin-Signaling Modulates Megakaryopoiesis at the Megakaryocyte-Erythrocyte Progenitor Stage in the Hematopoietic System.
Wnt signaling
cell-fate decision
erythrocytes
maegakaryopoiesis
megakaryocytes
β-catenin
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
04 Dec 2023
04 Dec 2023
Historique:
received:
11
09
2023
revised:
20
11
2023
accepted:
29
11
2023
medline:
9
12
2023
pubmed:
9
12
2023
entrez:
9
12
2023
Statut:
epublish
Résumé
The bone marrow (BM) hematopoietic system (HS) gives rise to blood cells originating from hematopoietic stem cells (HSCs), including megakaryocytes (MKs) and red blood cells (erythrocytes; RBCs). Many steps of the cell-fate decision remain to be elucidated, being important for cancer treatment. To explore the role of Wnt/β-catenin for MK and RBC differentiation, we activated β-catenin signaling in platelet-derived growth factor b (Pdgfb)-expressing cells of the HS using a Cre-lox approach (Ctnnb1
Identifiants
pubmed: 38067194
pii: cells12232765
doi: 10.3390/cells12232765
pmc: PMC10706863
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : LI 911/7-1
Organisme : Deutsche Forschungsgemeinschaft
ID : 390649896
Organisme : LOEWE Center for Personalized Translational Epilepsy Research
ID : CePTER
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