Review of Current Treatment Intensification Strategies for Prostate Cancer Patients.
ADT
LHRH agonist
prostate cancer
radiotherapy/radiation therapy
treatment intensification
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
28 Nov 2023
28 Nov 2023
Historique:
received:
30
10
2023
revised:
19
11
2023
accepted:
27
11
2023
medline:
9
12
2023
pubmed:
9
12
2023
entrez:
9
12
2023
Statut:
epublish
Résumé
Prostate cancer (PCa) used to be one of the most common nondermatologic cancers in men that can be treated only with surgery. However, a revolutionary breakthrough came in the 1980s with the introduction of long-acting luteinizing hormone-releasing hormone (LHRH) agonists for the curative treatment of PCa. This paradigm shift contributed to the combined use of androgen deprivation therapy (ADT), chemotherapy, and radiotherapy for the treatment. The latest data highlight the use of treatment intensification (TI), i.e., combined use of radiotherapy (RT) and hormonal or drug treatments, for localized or locally advanced PCa. Indeed, the results of combined modality treatments have shown a reduction in disease-specific mortality and improved overall survival. Although TI seems promising, more research studies are warranted to confirm its efficacy. This review summarizes the latest available outcome results of pivotal trials and clinical studies on the efficacy of TI.
Identifiants
pubmed: 38067321
pii: cancers15235615
doi: 10.3390/cancers15235615
pmc: PMC10705205
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Priority Research Center Program Grant
ID : NRF-2021R1A6A1A03038865
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