Systematic Analysis of 2'-
2′-O-alkyl modifications
aptamers
enzymatic oligonucleotide synthesis
polymerase mutants
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
02 Dec 2023
02 Dec 2023
Historique:
received:
30
10
2023
revised:
29
11
2023
accepted:
30
11
2023
medline:
9
12
2023
pubmed:
9
12
2023
entrez:
9
12
2023
Statut:
epublish
Résumé
Enzymatic oligonucleotide synthesis is used for the development of functional oligonucleotides selected by in vitro selection. Expanding available sugar modifications for in vitro selection helps the functional oligonucleotides to be used as therapeutics reagents. We previously developed a KOD DNA polymerase mutant, KOD DGLNK, that enzymatically synthesized fully-LNA- or 2'-
Identifiants
pubmed: 38067640
pii: molecules28237911
doi: 10.3390/molecules28237911
pmc: PMC10708256
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Agency for Medical Research and Development
ID : JP18ak0101102
Organisme : Japan Agency for Medical Research and Development
ID : JP22gm1610010
Organisme : Japan Agency for Medical Research and Development
ID : JP223fa727001
Organisme : Japan Agency for Medical Research and Development
ID : JP23ak0101207
Organisme : Japan Society for the Promotion of Science
ID : 19K15702
Organisme : Japan Society for the Promotion of Science
ID : 21K14743
Organisme : Japan Science and Technology Agency
ID : JPMJSP2138
Références
Proc Natl Acad Sci U S A. 2012 May 22;109(21):8067-72
pubmed: 22566643
Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):19971-6
pubmed: 23139410
Science. 1990 Aug 3;249(4968):505-10
pubmed: 2200121
PLoS One. 2010 Dec 07;5(12):e15004
pubmed: 21165148
Nature. 1990 Aug 30;346(6287):818-22
pubmed: 1697402
Nucleic Acids Res. 1997 Nov 15;25(22):4429-43
pubmed: 9358149
J Biotechnol. 2001 Jun 15;88(2):141-9
pubmed: 11403848
Ophthalmology. 2021 Apr;128(4):576-586
pubmed: 32882310
J Am Chem Soc. 2010 Mar 31;132(12):4141-51
pubmed: 20201573
ACS Chem Biol. 2016 May 20;11(5):1210-9
pubmed: 26860781
Chem Commun (Camb). 2016 Oct 25;52(87):12889-12892
pubmed: 27738673
Nucleic Acids Res. 1987 Aug 11;15(15):6131-48
pubmed: 3627981
Pharmaceutics. 2021 Jun 15;13(6):
pubmed: 34204006
Nucleic Acids Res. 2023 Apr 11;51(6):2529-2573
pubmed: 36881759
Nat Chem. 2016 Jun;8(6):556-62
pubmed: 27219699
Chem Asian J. 2017 Jun 19;12(12):1347-1352
pubmed: 28371464
Nucleic Acids Res. 2002 Jan 15;30(2):605-13
pubmed: 11788725
Biochemistry. 1993 Aug 3;32(30):7832-8
pubmed: 7688569
Nucleic Acids Res. 1995 Jun 11;23(11):2019-24
pubmed: 7541132
Nat Chem. 2023 Jan;15(1):91-100
pubmed: 36229679
Nucleic Acid Ther. 2023 Jun;33(3):178-192
pubmed: 37093127
Biochemistry. 1985 Oct 8;24(21):5810-7
pubmed: 3910084
J Am Chem Soc. 2020 Dec 23;142(51):21530-21537
pubmed: 33306372
Nat Rev Drug Discov. 2006 Feb;5(2):123-32
pubmed: 16518379
Immunopharmacology. 1999 May;42(1-3):219-30
pubmed: 10408383
Chembiochem. 2007 Mar 26;8(5):490-2
pubmed: 17315250
Nat Rev Drug Discov. 2017 Mar;16(3):181-202
pubmed: 27807347
Science. 2012 Apr 20;336(6079):341-4
pubmed: 22517858
Biochemistry. 2005 Jun 28;44(25):9045-57
pubmed: 15966728
J Med Chem. 1991 Mar;34(3):999-1002
pubmed: 2002478
Org Lett. 2003 Aug 21;5(17):3005-8
pubmed: 12916967
Anal Chem. 2013 May 21;85(10):4961-7
pubmed: 23662585