Detection of
ART
GSTM1 gene
female infertility
in vitro fertilization (IVF)
oxidative stress
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
23 Nov 2023
23 Nov 2023
Historique:
received:
16
10
2023
revised:
16
11
2023
accepted:
21
11
2023
medline:
9
12
2023
pubmed:
9
12
2023
entrez:
9
12
2023
Statut:
epublish
Résumé
Glutathione S-transferase (GST) M1 belongs to a family of detoxification enzymes and deficiency in enzyme activity is due to a homozygous deletion of the In the study group 125 women were classified as infertile according to WHO and 49 women with at least one successful pregnancy and no miscarriages, as control group. Genomic DNA from blood samples was isolated and PCR amplification was applied to determine the presence of Data analysis demonstrated a statistically significant higher presence of Our study results propose a possible involvement of GMST1 in female infertility and may help elucidate possible interactions between the microenvironment of oocytes and the oxidative stress.
Sections du résumé
BACKGROUND
BACKGROUND
Glutathione S-transferase (GST) M1 belongs to a family of detoxification enzymes and deficiency in enzyme activity is due to a homozygous deletion of the
METHODS
METHODS
In the study group 125 women were classified as infertile according to WHO and 49 women with at least one successful pregnancy and no miscarriages, as control group. Genomic DNA from blood samples was isolated and PCR amplification was applied to determine the presence of
RESULTS
RESULTS
Data analysis demonstrated a statistically significant higher presence of
CONCLUSIONS
CONCLUSIONS
Our study results propose a possible involvement of GMST1 in female infertility and may help elucidate possible interactions between the microenvironment of oocytes and the oxidative stress.
Identifiants
pubmed: 38068321
pii: jcm12237269
doi: 10.3390/jcm12237269
pmc: PMC10707227
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Fertil Steril. 2012 Aug;98(2):396-400
pubmed: 22633257
Fertil Steril. 2017 Sep;108(3):393-406
pubmed: 28760517
Best Pract Res Clin Obstet Gynaecol. 2023 Jun;88:102347
pubmed: 37244786
Cancer Epidemiol. 2015 Dec;39(6):947-55
pubmed: 26529288
Rev Assoc Med Bras (1992). 2020 Nov;66(11):1560-1565
pubmed: 33295410
Cell Tissue Res. 2016 Apr;364(1):1-7
pubmed: 26685866
Hum Reprod. 2004 Nov;19(11):2648-52
pubmed: 15333597
Hum Reprod Update. 2020 Jan 1;26(1):73-102
pubmed: 31821471
Public Health Genomics. 2021;24(5-6):261-266
pubmed: 34384077
Chem Biol Interact. 2014 Dec 5;224:164-75
pubmed: 25452175
Fa Yi Xue Za Zhi. 2009 Apr;25(2):109-11, 114
pubmed: 19537249
Diagnostics (Basel). 2023 Mar 15;13(6):
pubmed: 36980421
J Clin Med. 2023 Oct 26;12(21):
pubmed: 37959238
Hum Genet. 1996 Apr;97(4):516-20
pubmed: 8834254
Carcinogenesis. 2001 Jan;22(1):63-5
pubmed: 11159742
J Obstet Gynaecol. 2015 Jan;35(1):46-8
pubmed: 25010410
J Assist Reprod Genet. 2006 Apr;23(4):177-84
pubmed: 16758348
Int J Ophthalmol. 2018 Sep 18;11(9):1514-1520
pubmed: 30225227
Sci Rep. 2013;3:2258
pubmed: 23877133
Breast. 2013 Jun;22(3):335-43
pubmed: 23000097
Cell Mol Life Sci. 2020 Jun;77(12):2331-2342
pubmed: 31807814
PLoS One. 2011;6(5):e20157
pubmed: 21629772
In Vivo. 2016 Jul-Aug;30(4):473-7
pubmed: 27381611
Mol Biol Rep. 2013 Mar;40(3):2431-8
pubmed: 23238917
J Reprod Fertil. 1997 Jul;110(2):355-60
pubmed: 9306990
J Clin Med. 2023 Aug 30;12(17):
pubmed: 37685721
Antioxidants (Basel). 2023 Apr 16;12(4):
pubmed: 37107315
Biomarkers. 2013 Mar;18(2):151-4
pubmed: 23311983
Int J Appl Basic Med Res. 2021 Oct-Dec;11(4):243-247
pubmed: 34912688
Mol Biol Rep. 2011 Jan;38(1):89-94
pubmed: 20300859
Dan Med Bull. 2008 Feb;55(1):1-16
pubmed: 18321442
Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1461-7
pubmed: 19383894
J Assist Reprod Genet. 2015 Oct;32(10):1531-5
pubmed: 26350109
Reprod Biol Endocrinol. 2005 Jul 14;3:28
pubmed: 16018814
Cancer Cell Int. 2014 Nov 30;14(1):127
pubmed: 25477765
Curr Opin Obstet Gynecol. 2009 Jun;21(3):219-22
pubmed: 19469044
Environ Health Perspect. 2010 Mar;118(3):437-43
pubmed: 20194072
Reprod Biomed Online. 2013 Apr;26(4):313-22
pubmed: 23433732
Reprod Biol Endocrinol. 2004 Mar 23;2:12
pubmed: 15038829
Reprod Biomed Online. 2020 Nov;41(5):892-901
pubmed: 32855063
PLoS One. 2013;8(1):e54037
pubmed: 23342067
Reprod Biomed Online. 2005 Nov;11(5):641-50
pubmed: 16409717
Fertil Steril. 2009 Apr;91(4 Suppl):1496-8
pubmed: 18829006
Environ Toxicol Pharmacol. 2013 Mar;35(2):265-9
pubmed: 23357602
Nat Rev Dis Primers. 2019 Jan 24;5(1):7
pubmed: 30679436
Environ Sci Pollut Res Int. 2022 Jan;29(5):6622-6632
pubmed: 34453679
Redox Biol. 2021 Oct;46:102071
pubmed: 34340027