Neurobiology of Coughing in Children.
airway innervation
children
development
hypersensitivity
sensory
vagal
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
24 Nov 2023
24 Nov 2023
Historique:
received:
17
08
2023
revised:
17
11
2023
accepted:
22
11
2023
medline:
9
12
2023
pubmed:
9
12
2023
entrez:
9
12
2023
Statut:
epublish
Résumé
A cough is one of several defensive responses that protect and clear the airways of inhaled, aspirated or locally produced chemicals and matter. The neural components needed to initiate a cough begin to develop in utero, and at birth the airways and lungs already have a rich supply of sensory and motor-neural innervation. However, a cough is not always the primary defensive response to airway challenge in very young infants, but instead develops in the first postnatal months and matures further into puberty. Consequently, the clinical presentation of a troublesome cough in children may not be the same as in adults, exemplified by important differences in cough sensitivity and hypersensitivity between children and adults. This review will summarise key anatomical and functional concepts in airway neurobiology that may improve understanding of coughs in children.
Identifiants
pubmed: 38068335
pii: jcm12237285
doi: 10.3390/jcm12237285
pmc: PMC10707336
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
NPJ Prim Care Respir Med. 2016 Mar 03;26:16012
pubmed: 26937873
Am J Respir Crit Care Med. 2013 Nov 1;188(9):1069-75
pubmed: 24093551
J Appl Physiol (1985). 2012 Jul;113(1):39-46
pubmed: 22492938
Am J Respir Crit Care Med. 2015 Jul 1;192(1):30-9
pubmed: 25906337
Am J Respir Cell Mol Biol. 2014 Jul;51(1):43-55
pubmed: 24471696
J Physiol. 2020 Dec;598(24):5771-5787
pubmed: 33029786
Am J Respir Crit Care Med. 2021 Feb 1;203(3):348-355
pubmed: 32809840
Mayo Clin Proc. 2010 Mar;85(3 Suppl):S33-41
pubmed: 20194147
Eur Respir J. 2019 May 2;53(5):
pubmed: 30819813
J Neurosci. 2011 Feb 23;31(8):2948-58
pubmed: 21414916
J Clin Med. 2023 Jun 09;12(12):
pubmed: 37373643
Semin Neonatol. 2004 Jun;9(3):169-80
pubmed: 15050210
Pulm Pharmacol Ther. 2007;20(4):371-82
pubmed: 17118685
J Appl Physiol (1985). 2007 Apr;102(4):1429-38
pubmed: 17170207
Eur Respir J. 2014 Nov;44(5):1132-48
pubmed: 25142479
Am J Respir Cell Mol Biol. 1999 Apr;20(4):550-60
pubmed: 10100986
Chest. 2014 Jul;146(1):135-141
pubmed: 24556807
Neuroscience. 1986 Oct;19(2):605-27
pubmed: 3490633
Nat Rev Dis Primers. 2022 Jun 30;8(1):45
pubmed: 35773287
Respir Physiol Neurobiol. 2014 May 1;195:44-9
pubmed: 24566392
J Physiol. 2020 Jun;598(11):2257-2275
pubmed: 32237239
J Neurosci. 2015 May 6;35(18):7041-55
pubmed: 25948256
J Appl Physiol (1985). 1991 Apr;70(4):1617-26
pubmed: 2055843
Thorax. 2016 Apr;71(4):323-9
pubmed: 26860344
Pulm Pharmacol Ther. 2007;20(4):365-70
pubmed: 17374497
Chest. 2015 Jul;148(1):24-31
pubmed: 25856777
Front Physiol. 2014 Aug 28;5:322
pubmed: 25221517
J Physiol Pharmacol. 2008 Dec;59 Suppl 6:719-26
pubmed: 19218699
Pulm Pharmacol Ther. 2019 Feb;54:22-24
pubmed: 30445192
J Chem Neuroanat. 2014 Jan;55:18-23
pubmed: 24269509
Physiol Rev. 2016 Jul;96(3):975-1024
pubmed: 27279650
Eur Respir J. 2014 Nov;44(5):1149-55
pubmed: 25186267
Dev Dyn. 2001 May;221(1):48-60
pubmed: 11357193
J Physiol. 2004 Jun 1;557(Pt 2):543-58
pubmed: 15004208
Pediatr Pulmonol. 1985 Mar-Apr;1(2):112-26
pubmed: 3906539
Am J Physiol Regul Integr Comp Physiol. 2011 Feb;300(2):R369-77
pubmed: 20926760
Am J Med. 1997 Nov 24;103(5A):2S-8S
pubmed: 9422615
J Appl Physiol (1985). 2005 Jun;98(6):2197-203
pubmed: 15718399
J Clin Med. 2023 Jul 25;12(15):
pubmed: 37568280
Pulm Pharmacol Ther. 2004;17(6):369-76
pubmed: 15564078
Chest. 2018 Mar;153(3):675-679
pubmed: 29197546
Am J Respir Crit Care Med. 2007 Aug 15;176(4):327-32
pubmed: 17575093
Br J Anaesth. 2013 Jul;111(1):52-8
pubmed: 23794645
Lung. 2020 Feb;198(1):13-21
pubmed: 31834478
Handb Exp Pharmacol. 2009;(187):263-76
pubmed: 18825345
Clin Exp Pharmacol Physiol. 1997 Mar-Apr;24(3-4):261-8
pubmed: 9131295
Am J Respir Cell Mol Biol. 1999 Nov;21(5):607-20
pubmed: 10536120
Am J Physiol Lung Cell Mol Physiol. 2022 Jan 1;322(1):L50-L63
pubmed: 34755535