Relationships between CD34-, CD105- and bcl-2-Expression Levels and Contrast-Enhanced Ultrasound-Based Differential Diagnosis of Adnexal Tumours.

CD105 CD34 CEUS adnexal tumors bcl-2 contrast-enhanced ultrasound ovarian cancer ultrasonography

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
28 Nov 2023
Historique:
received: 05 10 2023
revised: 06 11 2023
accepted: 24 11 2023
medline: 9 12 2023
pubmed: 9 12 2023
entrez: 9 12 2023
Statut: epublish

Résumé

The relationships between CEUS parameters of adnexal tumours and postoperative immunohistochemical assessments of CD34, CD105 and bcl-2 were analysed. This study aimed to investigate whether contrast-enhanced ultrasonography (CEUS) parameters depend on the microvascular density of the tumour lesion found after surgery. Fifty-one patients with a diagnosis of adnexal tumours were included in this single-centre, prospective study. Participants underwent preoperative CEUS (contrast-enhanced ultrasound). Colour Doppler enhancement characterisation parameters (Ystart, Ymax and S) were determined. Immunohistochemical examination of histological specimens of the adnexal lesions was then carried out to determine the expression levels of the CD34, CD105 and bcl-2 proteins. Relationships between the aforementioned parameters were investigated. No significant statistical correlations were observed between CD34, CD105 and bcl2 expression levels and CEUS parameters, independently of whether the operated lesion was malignant or benign. Transvaginal CEUS is diagnostic for the detection of pathological neoplastic vascularisation of an adnexal lesion independent of the density of microcapillaries found postoperatively.

Identifiants

DOI: 10.3390/jcm12237372 PMID: 38068422 PMC: PMC10707409
pubmed: 38068422
pii: jcm12237372
doi: 10.3390/jcm12237372
pmc: PMC10707409
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Marek Szymanski (M)

Clinic of Gynaecology, Oncological Gynaecology and Gynaecological Endocrinology, 10th Military Research Hospital and Polyclinic, IPHC, Powstańców Warszawy Str. 5, 85-681 Bydgoszcz, Poland.
Department of Obstetrics, Female Pathology and Oncological Gynaecology, University Hospital No. 2, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus, University in Toruń, Ujejskiego St. 75, 85-168 Bydgoszcz, Poland.
NZOZ Centrum Medyczne "Genesis"-Clinic of Infertility Treatment, Waleniowa Str., 24, 85-435 Bydgoszcz, Poland.
ORCID: 0000-0002-3937-5710

Iwona Florczyk (I)

Department of Internal Medicine, Independent Public Health Care, Tadeusza Kościuszki 6, 88-300 Mogilno, Poland.
Individual Medical Practice Iwona Florczyk, Wesolowskich 5/3, 88-300 Mogilno, Poland.

Radoslaw Janicki (R)

Clinic of Gynaecology, Oncological Gynaecology and Gynaecological Endocrinology, 10th Military Research Hospital and Polyclinic, IPHC, Powstańców Warszawy Str. 5, 85-681 Bydgoszcz, Poland.
NZOZ Centrum Medyczne "Genesis"-Clinic of Infertility Treatment, Waleniowa Str., 24, 85-435 Bydgoszcz, Poland.

Piotr Bernard (P)

Clinic of Gynaecology, Oncological Gynaecology and Gynaecological Endocrinology, 10th Military Research Hospital and Polyclinic, IPHC, Powstańców Warszawy Str. 5, 85-681 Bydgoszcz, Poland.

Piotr Domaracki (P)

Clinic of Gynaecology, Oncological Gynaecology and Gynaecological Endocrinology, 10th Military Research Hospital and Polyclinic, IPHC, Powstańców Warszawy Str. 5, 85-681 Bydgoszcz, Poland.
ORCID: 0000-0002-2745-530X

Lukasz Brycht (L)

Clinic of Gynaecology, Oncological Gynaecology and Gynaecological Endocrinology, 10th Military Research Hospital and Polyclinic, IPHC, Powstańców Warszawy Str. 5, 85-681 Bydgoszcz, Poland.
Department of General and Oncological Surgery, Specialist Hospital in Włocławek, 49 Wieniecka Street, 87-800 Włocławek, Poland.

Robert Szyca (R)

Clinic of Surgery and Oncological Surgery, 10th Military Research Hospital and Polyclinic, IPHC, 85-681 Bydgoszcz, Poland.

Angelika Szymanska (A)

NZOZ Centrum Medyczne "Genesis"-Clinic of Infertility Treatment, Waleniowa Str., 24, 85-435 Bydgoszcz, Poland.
Faculty of Medicine, Medical University in Poznań, 61-701 Poznań, Poland.

Julia Paniutycz (J)

Gynecology, Obstetrics and Pregnancy Pathology Department, Multi-Speciality City Hospital in Bydgoszcz, 19 Szpitalna Street, 85-172 Bydgoszcz, Poland.
ORCID: 0009-0000-0217-0247

Classifications MeSH