A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonuclease 1.
APE1
DNA damage response
POLH
Pol eta
X-ray crystallography
cancer therapeutics
fragment-based drug discovery
polymerases
structure-based drug discovery
synthetic lethality
targeted protein degradation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Nov 2023
23 Nov 2023
Historique:
received:
29
08
2023
revised:
26
10
2023
accepted:
27
10
2023
medline:
9
12
2023
pubmed:
9
12
2023
entrez:
9
12
2023
Statut:
epublish
Résumé
The ability to quickly discover reliable hits from screening and rapidly convert them into lead compounds, which can be verified in functional assays, is central to drug discovery. The expedited validation of novel targets and the identification of modulators to advance to preclinical studies can significantly increase drug development success. Our SaXPy
Identifiants
pubmed: 38068959
pii: ijms242316637
doi: 10.3390/ijms242316637
pmc: PMC10706420
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCATS NIH HHS
ID : R43 TR001736
Pays : United States
Organisme : NIGMS NIH HHS
ID : R44 GM132796
Pays : United States
Organisme : NCI NIH HHS
ID : R43 CA254552
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008280
Pays : United States
Organisme : NIH HHS
ID : ES029518, CA148629, ES014811, ES028949, CA238061, CA236911, AG069740 and ES032522
Pays : United States
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