HLA-E and Its Soluble Form as Indicators of a Sex-Specific Immune Response in Patients with Oral Squamous Cell Carcinoma.

HLA-E immunotherapy oral squamous cell carcinoma (OSCC) sex-related differences in immune response soluble HLA-E

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
24 Nov 2023
Historique:
received: 24 10 2023
revised: 07 11 2023
accepted: 10 11 2023
medline: 9 12 2023
pubmed: 9 12 2023
entrez: 9 12 2023
Statut: epublish

Résumé

The human leukocyte antigene E (HLA-E) is associated with tumorigenesis in various cancers. Immunoncology along with sex-specific aspects in cancer therapy are now in scientific focus. Therefore, immunohistochemical HLA-E expression was retrospectively analysed in a cohort of oral squamous cell carcinomas (OSCC) after surgical therapy. Then, serum concentration of HLA-E (sHLA-E) was quantified in a prospective cohort by enzyme-linked immunosorbent assay. High HLA-E expression was associated with advanced UICC stage (Spearman's correlation:

Identifiants

pubmed: 38069020
pii: ijms242316699
doi: 10.3390/ijms242316699
pmc: PMC10706335
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Anne Radermacher (A)

Dentistry, Stomatology and Orthodontics, Chair of Oral and Maxillofacial Surgery, Saarland University, 66421 Homburg, Germany.

Michael Fehrenz (M)

Department of Oral and Maxillofacial Surgery, Saarland University, 66421 Homburg, Germany.

Tamara Bellin (T)

Department of Oral and Maxillofacial Surgery, Saarland University, 66421 Homburg, Germany.

Carolina Claßen (C)

Department of Oral and Maxillofacial Surgery, Saarland University, 66421 Homburg, Germany.

Laura Möller (L)

Dentistry, Stomatology and Orthodontics, Chair of Oral and Maxillofacial Surgery, Saarland University, 66421 Homburg, Germany.

Ann-Kristin Struckmeier (AK)

Department of Oral and Maxillofacial Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.

Mathias Wagner (M)

Department of Pathology, Saarland University Medical Center, 66421 Homburg, Germany.

Philipp Wartenberg (P)

Department of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, 66421 Homburg, Germany.

Julius Moratin (J)

Department of Oral and Maxillofacial Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Christian Freudlsperger (C)

Department of Oral and Maxillofacial Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Kolja Freier (K)

Department of Oral and Maxillofacial Surgery, Saarland University, 66421 Homburg, Germany.

Dominik Horn (D)

Department of Oral and Maxillofacial Surgery, Saarland University, 66421 Homburg, Germany.

Classifications MeSH