G6PD Orchestrates Genome-Wide DNA Methylation and Gene Expression in the Vascular Wall.
DNA methylation
G6PD variant
human SNP
rat
vascular biology
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Nov 2023
24 Nov 2023
Historique:
received:
04
10
2023
revised:
22
11
2023
accepted:
22
11
2023
medline:
9
12
2023
pubmed:
9
12
2023
entrez:
9
12
2023
Statut:
epublish
Résumé
Recent advances have revealed the importance of epigenetic modifications to gene regulation and transcriptional activity. DNA methylation, a determinant of genetic imprinting and the de novo silencing of genes genome-wide, is known to be controlled by DNA methyltransferases (DNMT) and demethylases (TET) under disease conditions. However, the mechanism(s)/factor(s) influencing the expression and activity of epigenetic writers and erasers, and thus DNA methylation, in healthy vascular tissue is incompletely understood. Based on our recent studies, we hypothesized that glucose-6-phosphate dehydrogenase (G6PD) is a modifier of DNMT and TET expression and activity and an enabler of gene expression. In the aorta of CRISPR-edited rats with the Mediterranean G6PD variant, we determined DNA methylation by whole-genome bisulfite sequencing, gene expression by RNA sequencing, and large artery stiffness by echocardiography. Here, we documented higher expression of
Identifiants
pubmed: 38069050
pii: ijms242316727
doi: 10.3390/ijms242316727
pmc: PMC10706803
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Heart Lung and Blood Institute
ID : RO1HL132574
Organisme : National Heart Lung and Blood Institute
ID : RO1HL166546
Organisme : American Heart Association
ID : 17GRNT33670454
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