Early neurological deterioration in patients with acute ischemic stroke is linked to unfavorable cerebral venous outflow.

Early neurological deterioration (END) is associated with poor outcomes in patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO). Causes of END after mechanical thrombectomy (MT) include unsuccessful recanalization and reperfusion hemorrhages. However, little is known about END excluding the aforementioned causes. We aimed to investigate factors associated with unexplained END (END Multicenter retrospective study of AIS-LVO patients with successful MT (mTICI 2b-3). On admission CT angiography (CTA), pial arterial collaterals and venous outflow (VO) were assessed using the modified Tan-Scale and the Cortical Vein Opacification Score (COVES), respectively. END A total of 620 patients met the inclusion criteria. END Unfavorable VO on admission CTA was associated with END

Déclaration de conflit d'intérêts

Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Dr J.J. HEIT reports consulting for Medtronic and MicroVention and Medical and Scientific Advisory Board membership for iSchemaView. Dr G.W. ALBERS reports equity and consulting for iSchemaView and consulting from Medtronic. Dr H. KNIEP reports an ownership stake in Eppdata GmbH and compensation from Eppdata GmbH for consultant services. Dr M. WINTERMARK reports grants and funding from the National Institutes of Health under the grant numbers (1U01 NS086872-01, 1U01 NS087748-01, and 1R01 NS104094). Dr J. FIEHLER reports grants and personal fees from Acandis, Cerenovus, MicroVention, Medtronic, Stryker, Phenox and grants from Route 92 outside the submitted work. Dr T. D. FAIZY reports grants from the German Research Foundation (DFG) during the conduct of the study (Project Number: 411621970). Dres M.G. LANSBERG, G. BROOCKS, C.P. STRACKE, A. GUENEGO, D. PAECH, L. WINKELMEIER, M. SCHELL and C. HEITKAMP report no disclosures relevant to the manuscript.