Toxicokinetics of rare earth element oxides administered intravenously to rats.

Blood Excreta Rare earth elements (REEs) Tissues Toxicokinetics

Journal

Chemosphere
ISSN: 1879-1298
Titre abrégé: Chemosphere
Pays: England
ID NLM: 0320657

Informations de publication

Date de publication:
07 Dec 2023
Historique:
received: 17 07 2023
revised: 03 10 2023
accepted: 02 12 2023
medline: 10 12 2023
pubmed: 10 12 2023
entrez: 9 12 2023
Statut: aheadofprint

Résumé

Rare earth elements (REEs) are increasingly used in a wide range of applications. However, their toxicokinetic behaviors in animals and humans are not yet fully documented, hindering health risk assessments. We used a rat experimental model to provide novel data on the toxicokinetics of the insoluble oxide forms of praseodymium (Pr), neodymium (Nd), cerium (Ce) and yttrium (Y) administered intravenously. Detailed blood, urinary and fecal time courses were documented through serial sampling over 21 days in male Sprague-Dawley rats exposed to a mixture of these REE oxides administered at two different doses (0.3 or 1 mg kg

Identifiants

DOI: 10.1016/j.chemosphere.2023.140895 PMID: 38070608
pubmed: 38070608
pii: S0045-6535(23)03165-X
doi: 10.1016/j.chemosphere.2023.140895
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

140895

Informations de copyright

Copyright © 2023. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Malek Jomaa (M)

Deparent of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, And Public Health Research Center (CReSP), University of Montreal, Roger-Gaudry Building, U424, P.O. Box 6128, Main Station, Montreal, Quebec, Canada, H3C 3J7.

Guillaume Pelletier (G)

Hazard Identification Division, Environmental Health Science and Research Bureau, Health Canada, K1A 0K9, Ottawa, ON, Canada.

Denis Dieme (D)

Deparent of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, And Public Health Research Center (CReSP), University of Montreal, Roger-Gaudry Building, U424, P.O. Box 6128, Main Station, Montreal, Quebec, Canada, H3C 3J7.

Houssame-Eddine Ahabchane (HE)

Department of Chemistry, University of Montreal, 1375 Thérèse-Lavoie-Roux Avenue, Montréal, Quebec, H2V 0B3, Canada.

Jonathan Côté (J)

Deparent of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, And Public Health Research Center (CReSP), University of Montreal, Roger-Gaudry Building, U424, P.O. Box 6128, Main Station, Montreal, Quebec, Canada, H3C 3J7.

Hamadi Fetoui (H)

Laboratory of Toxicology-Microbiology and Environmental Health (17ES06), Faculty of Sciences of Sfax, University of Sfax, BP1171, 3000 Sfax, Tunisia.

Aristine Nnomo Assene (AN)

Deparent of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, And Public Health Research Center (CReSP), University of Montreal, Roger-Gaudry Building, U424, P.O. Box 6128, Main Station, Montreal, Quebec, Canada, H3C 3J7.

Andy Nong (A)

ScitoVation, LLC, 6 Davis Drive, Suite 146, Durham, NC, USA, 27709.

Kevin J Wilkinson (KJ)

Department of Chemistry, University of Montreal, 1375 Thérèse-Lavoie-Roux Avenue, Montréal, Quebec, H2V 0B3, Canada.

Michèle Bouchard (M)

Deparent of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, And Public Health Research Center (CReSP), University of Montreal, Roger-Gaudry Building, U424, P.O. Box 6128, Main Station, Montreal, Quebec, Canada, H3C 3J7. Electronic address: michele.bouchard@umontreal.ca.

Classifications MeSH