Agitation-Induced Aggregation of Lysine- and Interchain Cysteine-Linked Antibody-Drug Conjugates.
antibody–drug conjugate(s) (ADC)
conjugation
developability
high-throughput technology(s)
monoclonal antibody(s)
physical stability
protein aggregation
Journal
Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R
Informations de publication
Date de publication:
07 Dec 2023
07 Dec 2023
Historique:
received:
24
09
2023
revised:
01
12
2023
accepted:
02
12
2023
medline:
10
12
2023
pubmed:
10
12
2023
entrez:
9
12
2023
Statut:
aheadofprint
Résumé
Drug conjugation to an antibody can affect its stability, which depends on factors such as the conjugation technique used, drug-linker properties, and stress encountered. This study focused on the effects of agitation stress on the physical stability of two lysine (ADC-K) and two interchain cysteine (ADC-C) conjugates of an IgG
Identifiants
pubmed: 38070776
pii: S0022-3549(23)00511-7
doi: 10.1016/j.xphs.2023.12.003
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023. Published by Elsevier Inc.