Unravelling the mechanism of neurotensin recognition by neurotensin receptor 1.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
09 Dec 2023
09 Dec 2023
Historique:
received:
08
06
2023
accepted:
26
11
2023
medline:
10
12
2023
pubmed:
10
12
2023
entrez:
9
12
2023
Statut:
epublish
Résumé
The conformational ensembles of G protein-coupled receptors (GPCRs) include inactive and active states. Spectroscopy techniques, including NMR, show that agonists, antagonists and other ligands shift the ensemble toward specific states depending on the pharmacological efficacy of the ligand. How receptors recognize ligands and the kinetic mechanism underlying this population shift is poorly understood. Here, we investigate the kinetic mechanism of neurotensin recognition by neurotensin receptor 1 (NTS
Identifiants
pubmed: 38071229
doi: 10.1038/s41467-023-44010-7
pii: 10.1038/s41467-023-44010-7
pmc: PMC10710507
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8155Subventions
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : 1081844
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : 1141034
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : 1081844
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : 1141034
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : 1081844
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : 1141034
Informations de copyright
© 2023. The Author(s).
Références
Cell Rep. 2016 Jan 5;14(1):32-42
pubmed: 26725117
Eur J Biochem. 1982 May;124(1):117-24
pubmed: 7084220
Nature. 2016 May 04;533(7602):265-8
pubmed: 27144352
J Biol Chem. 2020 May 22;295(21):7404-7417
pubmed: 32303636
Nat Commun. 2015 Jul 24;6:7895
pubmed: 26205105
Front Pharmacol. 2019 Feb 19;10:125
pubmed: 30837883
Structure. 2020 Mar 3;28(3):371-377.e3
pubmed: 31978323
Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12733-12738
pubmed: 30463958
Cell. 2021 Apr 1;184(7):1884-1894.e14
pubmed: 33743210
J Chem Theory Comput. 2018 Aug 14;14(8):4467-4473
pubmed: 29965755
Nat Commun. 2022 Dec 2;13(1):7428
pubmed: 36460632
Trends Pharmacol Sci. 1999 Jul;20(7):302-9
pubmed: 10390649
Science. 2020 Feb 21;367(6480):888-892
pubmed: 32079768
Nature. 2016 Jul 7;535(7610):182-6
pubmed: 27362234
Methods Enzymol. 2009;463:631-45
pubmed: 19892196
Adv Exp Med Biol. 2019;1163:225-251
pubmed: 31707706
Curr Opin Struct Biol. 2021 Aug;69:169-176
pubmed: 34130235
Biochim Biophys Acta Biomembr. 2018 Jun;1860(6):1372-1383
pubmed: 29596791
Nature. 2017 Jul 6;547(7661):68-73
pubmed: 28607487
PLoS Comput Biol. 2016 Sep 16;12(9):e1005067
pubmed: 27636092
Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E655-62
pubmed: 24453215
Chemistry. 2014 Aug 25;20(35):11058-68
pubmed: 25044441
Science. 2012 Mar 2;335(6072):1106-10
pubmed: 22267580
Cell. 2019 Jan 24;176(3):468-478.e11
pubmed: 30639099
Phys Chem Chem Phys. 2014 Apr 14;16(14):6323-31
pubmed: 24317797
Cell Chem Biol. 2016 Mar 17;23(3):392-403
pubmed: 26991104
J Biomol NMR. 2015 May;62(1):97-103
pubmed: 25813845
Trends Pharmacol Sci. 2017 Dec;38(12):1110-1124
pubmed: 29074251
Science. 2019 May 24;364(6442):775-778
pubmed: 31072904
Prog Nucl Magn Reson Spectrosc. 2012 Apr;62:1-33
pubmed: 22364614
Protein Eng. 1999 Sep;12(9):713-20
pubmed: 10506280
Cell Rep. 2023 Jan 31;42(1):112015
pubmed: 36680775
ACS Pharmacol Transl Sci. 2020 Apr 29;3(4):690-705
pubmed: 32832871
Nat Commun. 2020 May 5;11(1):2216
pubmed: 32371991
Anal Chem. 2019 Jul 2;91(13):8008-8016
pubmed: 31099554
J Am Chem Soc. 2022 Jun 15;144(23):10241-10250
pubmed: 35647863
Science. 2000 Aug 4;289(5480):739-45
pubmed: 10926528
ACS Chem Neurosci. 2020 Oct 7;11(19):3130-3143
pubmed: 32865974
Methods Mol Biol. 2020;2127:339-358
pubmed: 32112332
Proc Natl Acad Sci U S A. 1958 Feb;44(2):98-104
pubmed: 16590179
Eur J Pharmacol. 2017 Jun 15;805:1-13
pubmed: 28341345
Int J Mol Sci. 2020 Aug 18;21(16):
pubmed: 32824756
Sci Adv. 2021 Jan 27;7(5):
pubmed: 33571132
Bioinformatics. 2021 Apr 19;37(2):270-272
pubmed: 32722756
Nat Commun. 2019 Jul 23;10(1):3289
pubmed: 31337749
Biochemistry. 2012 Jul 31;51(30):5894-902
pubmed: 22775458
Angew Chem Int Ed Engl. 2015 Dec 21;54(52):15771-6
pubmed: 26568421
Science. 2022 Jul 8;377(6602):222-228
pubmed: 35857540
Structure. 2018 Feb 6;26(2):259-269.e5
pubmed: 29395784
Nat Commun. 2020 Dec 2;11(1):6162
pubmed: 33268777
FEBS J. 2021 Apr;288(8):2513-2528
pubmed: 33621418
J Mol Biol. 2023 Oct 15;435(20):168244
pubmed: 37625583
Cell. 2015 May 21;161(5):1101-1111
pubmed: 25981665
Nat Protoc. 2007;2(10):2601-7
pubmed: 17948003
Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2122682119
pubmed: 35377814
J Med Chem. 2017 Apr 27;60(8):3303-3313
pubmed: 28368584
J Biomol Screen. 2013 Oct;18(9):947-66
pubmed: 23945874
Chem Commun (Camb). 2020 Nov 25;56(91):14167-14170
pubmed: 33079104
Cell. 2020 Jun 11;181(6):1364-1379.e14
pubmed: 32470395
Nucleic Acids Res. 2022 Jan 7;50(D1):D543-D552
pubmed: 34723319
Proteins. 2012 Oct;80(10):2369-83
pubmed: 22641560
Nat Commun. 2023 Jun 7;14(1):3328
pubmed: 37286565
J Biol Chem. 1996 Jun 21;271(25):15060-8
pubmed: 8663052
Gastroenterol Res Pract. 2017;2017:6456257
pubmed: 28316623
Angew Chem Int Ed Engl. 2013 Oct 4;52(41):10762-5
pubmed: 23956158
Nat Commun. 2016 Feb 24;7:10842
pubmed: 26905976
Nat Commun. 2012;3:1045
pubmed: 22948827
Annu Rev Pharmacol Toxicol. 2013;53:531-56
pubmed: 23140243
Nat Struct Mol Biol. 2013 May;20(5):539-41
pubmed: 23649361
Annu Rev Biochem. 2018 Jun 20;87:897-919
pubmed: 29925258
J Med Chem. 2017 May 25;60(10):4126-4134
pubmed: 28140580
Protein Expr Purif. 2005 May;41(1):207-34
pubmed: 15915565
Structure. 2022 Mar 3;30(3):329-337.e5
pubmed: 34895472