The activating receptor NKp65 is selectively expressed by human ILC3 and demarcates ILC3 from mature NK cells.
Innate immunity ⋅ Innate lymphocytes ⋅ NK cells ⋅ NK cell receptors ⋅ ILC3 ⋅ C-type lectin-like receptors ⋅ Skin
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
10 Dec 2023
10 Dec 2023
Historique:
revised:
05
12
2023
received:
06
12
2022
accepted:
07
12
2023
medline:
11
12
2023
pubmed:
11
12
2023
entrez:
10
12
2023
Statut:
aheadofprint
Résumé
Innate lymphocytes comprise cytotoxic Natural Killer (NK) cells and tissue-resident innate lymphoid cells (ILC) that are subgrouped according to their cytokine profiles into group 1 ILC (ILC1), ILC2, and ILC3. However, cell surface receptors unambiguously defining or specifically activating such ILC subsets are scarcely known. Here, we report on the physiologic expression of the human activating C-type lectin-like receptor (CTLR) NKp65, a high affinity receptor for the keratinocyte-associated CTLR KACL. Tracking rare NKp65 transcripts in human blood, we identify ILC3 to selectively express NKp65. NKp65 expression not only demarcates "bona fide" ILC3 from likewise RORγt-expressing ILC precursors and lymphoid tissue inducer cells (LTis), but also from mature NK cells which acquire the NKp65-relative NKp80 during a Notch-dependent differentiation from NKp65
Identifiants
pubmed: 38072999
doi: 10.1002/eji.202250318
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2250318Informations de copyright
This article is protected by copyright. All rights reserved.