Evaluation of the Effect of Propofol-Remifentanil and Propofol-Hydralazine on the Bleeding Volume During Dacryocystorhinostomy Surgery Under General Anesthesia.
Bleeding
dacryocystorhinostomy
hydralazine
hypotension
propofol
remifentanil
Journal
Advanced biomedical research
ISSN: 2277-9175
Titre abrégé: Adv Biomed Res
Pays: India
ID NLM: 101586897
Informations de publication
Date de publication:
2023
2023
Historique:
received:
19
02
2022
revised:
17
06
2022
accepted:
18
06
2022
medline:
11
12
2023
pubmed:
11
12
2023
entrez:
11
12
2023
Statut:
epublish
Résumé
The present study was performed to compare the effectiveness of propofol-remifentanil and propofol-hydralazine in inducing controlled hypotension in patients undergoing the dacryocystorhinostomy (DCR) surgery and reducing their bleeding volume during surgery. The present double-blind, randomized clinical trial was performed on 70 patients who were candidates for DCR surgery and divided into two groups. In both the groups, general anesthesia protocol was performed. Moreover, in the first group, a syringe containing 2 mg of remifentanil in 20 ml of distilled water (0.1 mg/ml) was infused at the rate of 0.15 μg/kg/min (P + R group). In the second group, a syringe containing 20 mg of hydralazine in 20 ml of distilled water (1 mg/ml) was infused at the rate of 0.5-10 mg/h (P + H group). The hemodynamic parameters were not significantly different between the two groups in the studied times ( According to the results of this study, there was no significant difference between the P + H and P + R groups in terms of fluctuations in the hemodynamic parameters and the occurrence of complications. However, a reduction in the bleeding volume and a higher satisfaction level of the surgeon were observed in the P + R group compared with the P + H group.
Sections du résumé
Background
UNASSIGNED
The present study was performed to compare the effectiveness of propofol-remifentanil and propofol-hydralazine in inducing controlled hypotension in patients undergoing the dacryocystorhinostomy (DCR) surgery and reducing their bleeding volume during surgery.
Materials and Methods
UNASSIGNED
The present double-blind, randomized clinical trial was performed on 70 patients who were candidates for DCR surgery and divided into two groups. In both the groups, general anesthesia protocol was performed. Moreover, in the first group, a syringe containing 2 mg of remifentanil in 20 ml of distilled water (0.1 mg/ml) was infused at the rate of 0.15 μg/kg/min (P + R group). In the second group, a syringe containing 20 mg of hydralazine in 20 ml of distilled water (1 mg/ml) was infused at the rate of 0.5-10 mg/h (P + H group).
Results
UNASSIGNED
The hemodynamic parameters were not significantly different between the two groups in the studied times (
Conclusion
UNASSIGNED
According to the results of this study, there was no significant difference between the P + H and P + R groups in terms of fluctuations in the hemodynamic parameters and the occurrence of complications. However, a reduction in the bleeding volume and a higher satisfaction level of the surgeon were observed in the P + R group compared with the P + H group.
Identifiants
pubmed: 38073730
doi: 10.4103/abr.abr_57_22
pii: ABR-12-207
pmc: PMC10699216
doi:
Types de publication
Journal Article
Langues
eng
Pagination
207Informations de copyright
Copyright: © 2023 Advanced Biomedical Research.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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