External Evaluation of a Mammography-based Deep Learning Model for Predicting Breast Cancer in an Ethnically Diverse Population.

Breast Cancer Computer Applications Convolutional Neural Network Deep Learning Algorithms Epidemiology Informatics Machine Learning Mammography Oncology Radiomics

Journal

Radiology. Artificial intelligence
ISSN: 2638-6100
Titre abrégé: Radiol Artif Intell
Pays: United States
ID NLM: 101746556

Informations de publication

Date de publication:
Nov 2023
Historique:
received: 02 01 2023
revised: 25 05 2023
accepted: 03 07 2023
medline: 11 12 2023
pubmed: 11 12 2023
entrez: 11 12 2023
Statut: epublish

Résumé

To externally evaluate a mammography-based deep learning (DL) model (Mirai) in a high-risk racially diverse population and compare its performance with other mammographic measures. A total of 6435 screening mammograms in 2096 female patients (median age, 56.4 years ± 11.2 [SD]) enrolled in a hospital-based case-control study from 2006 to 2020 were retrospectively evaluated. Pathologically confirmed breast cancer was the primary outcome. Mirai scores were the primary predictors. Breast density and Breast Imaging Reporting and Data System (BI-RADS) assessment categories were comparative predictors. Performance was evaluated using area under the receiver operating characteristic curve (AUC) and concordance index analyses. Mirai achieved 1- and 5-year AUCs of 0.71 (95% CI: 0.68, 0.74) and 0.65 (95% CI: 0.64, 0.67), respectively. One-year AUCs for nondense versus dense breasts were 0.72 versus 0.58 ( A mammography DL model showed good performance in a high-risk external dataset enriched for African American patients, benign breast disease, and

Identifiants

DOI: 10.1148/ryai.220299 PMID: 38074785 PMC: PMC10698602
pubmed: 38074785
doi: 10.1148/ryai.220299
pmc: PMC10698602
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e220299

Subventions

Organisme : NCI NIH HHS
ID : K12 CA139160
Pays : United States
Organisme : NCI NIH HHS
ID : P20 CA233307
Pays : United States
Organisme : NIDCR NIH HHS
ID : R56 DE030958
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA243075
Pays : United States

Informations de copyright

© 2023 by the Radiological Society of North America, Inc.

Déclaration de conflit d'intérêts

Disclosures of conflicts of interest: O.J.O. No relevant relationships. A.E.W. No relevant relationships. F.M.H. Funding from American Society of Clinical Oncology/Breast Cancer Research Foundation Young Investigator Award (2022YIA-6675470300), Department of Defense (DoD) Breakthrough Level 2 Award (BC211095P1), American Cancer Society Institutional Research Grant, National Institutes of Health (NIH)/National Cancer Institute (NCI) (K12CA139160), and Cancer Research Foundation Young Investigator Award. F.Z. No relevant relationships. T.F.Y. No relevant relationships. Y.Z. No relevant relationships. A.T.P. Funding from NIH/National Institute of Dental and Craniofacial Research (R56-DE030958), NIH/NCI (U01-CA243075), DoD Breakthrough Cancer Research program (BC211095), Horizon (2021-SC1-BHC), Stand Up to Cancer–Fanconi Anemia Research Fund–Farrah Fawcett Foundation, NCI/Department of Energy Innovative Methodologies and New Data for Predictive Oncology Model Evaluation (IMPROVE) project IAA; grants or contracts from AbbVie and Kura Oncology; honorarium from AbbVie; advisory board for Prelude, Elevar Therapeutics, Privo, and Ayala. M.L. No relevant relationships. B.S.A. No relevant relationships. K.K. No relevant relationships. G.S.K. No relevant relationships. O.I.O. Funding from the Susan & Richard Kiphart Family Foundation; leadership role with American Cancer Society and MacArthur Foundation; stock or stock options with CancerIq, Tempus, and Healthwell; receipt of equipment or services from Genentech/Roche, Cepheid, and Color Genomics. H.A. No relevant relationships. D.H. No relevant relationships.

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Auteurs

Olasubomi J Omoleye (OJ)

From the Center for Clinical Cancer Genetics and Global Health, Department of Medicine (O.J.O., A.E.W., T.F.Y., Y.Z., B.S.A., O.I.O.), Data Science Institute (A.E.W.), Division of Hematology/Oncology, Department of Medicine (F.M.H., A.T.P.), Department of Public Health Sciences (F.Z., D.H.), Department of Computer Science (M.L.), and Department of Radiology (K.K., G.S.K., H.A.), The University of Chicago, 5841 S Maryland Ave, MC 2000, Chicago, IL 60637; Department of Computer Science, Lagos State University, Lagos, Nigeria (B.S.A.).
ORCID: 0000-0002-6922-9298

Anna E Woodard (AE)

From the Center for Clinical Cancer Genetics and Global Health, Department of Medicine (O.J.O., A.E.W., T.F.Y., Y.Z., B.S.A., O.I.O.), Data Science Institute (A.E.W.), Division of Hematology/Oncology, Department of Medicine (F.M.H., A.T.P.), Department of Public Health Sciences (F.Z., D.H.), Department of Computer Science (M.L.), and Department of Radiology (K.K., G.S.K., H.A.), The University of Chicago, 5841 S Maryland Ave, MC 2000, Chicago, IL 60637; Department of Computer Science, Lagos State University, Lagos, Nigeria (B.S.A.).
ORCID: 0000-0002-8640-5417

Frederick M Howard (FM)

From the Center for Clinical Cancer Genetics and Global Health, Department of Medicine (O.J.O., A.E.W., T.F.Y., Y.Z., B.S.A., O.I.O.), Data Science Institute (A.E.W.), Division of Hematology/Oncology, Department of Medicine (F.M.H., A.T.P.), Department of Public Health Sciences (F.Z., D.H.), Department of Computer Science (M.L.), and Department of Radiology (K.K., G.S.K., H.A.), The University of Chicago, 5841 S Maryland Ave, MC 2000, Chicago, IL 60637; Department of Computer Science, Lagos State University, Lagos, Nigeria (B.S.A.).

Fangyuan Zhao (F)

From the Center for Clinical Cancer Genetics and Global Health, Department of Medicine (O.J.O., A.E.W., T.F.Y., Y.Z., B.S.A., O.I.O.), Data Science Institute (A.E.W.), Division of Hematology/Oncology, Department of Medicine (F.M.H., A.T.P.), Department of Public Health Sciences (F.Z., D.H.), Department of Computer Science (M.L.), and Department of Radiology (K.K., G.S.K., H.A.), The University of Chicago, 5841 S Maryland Ave, MC 2000, Chicago, IL 60637; Department of Computer Science, Lagos State University, Lagos, Nigeria (B.S.A.).

Toshio F Yoshimatsu (TF)

From the Center for Clinical Cancer Genetics and Global Health, Department of Medicine (O.J.O., A.E.W., T.F.Y., Y.Z., B.S.A., O.I.O.), Data Science Institute (A.E.W.), Division of Hematology/Oncology, Department of Medicine (F.M.H., A.T.P.), Department of Public Health Sciences (F.Z., D.H.), Department of Computer Science (M.L.), and Department of Radiology (K.K., G.S.K., H.A.), The University of Chicago, 5841 S Maryland Ave, MC 2000, Chicago, IL 60637; Department of Computer Science, Lagos State University, Lagos, Nigeria (B.S.A.).
ORCID: 0000-0003-2674-8159

Yonglan Zheng (Y)

From the Center for Clinical Cancer Genetics and Global Health, Department of Medicine (O.J.O., A.E.W., T.F.Y., Y.Z., B.S.A., O.I.O.), Data Science Institute (A.E.W.), Division of Hematology/Oncology, Department of Medicine (F.M.H., A.T.P.), Department of Public Health Sciences (F.Z., D.H.), Department of Computer Science (M.L.), and Department of Radiology (K.K., G.S.K., H.A.), The University of Chicago, 5841 S Maryland Ave, MC 2000, Chicago, IL 60637; Department of Computer Science, Lagos State University, Lagos, Nigeria (B.S.A.).
ORCID: 0000-0001-6597-7072

Alexander T Pearson (AT)

From the Center for Clinical Cancer Genetics and Global Health, Department of Medicine (O.J.O., A.E.W., T.F.Y., Y.Z., B.S.A., O.I.O.), Data Science Institute (A.E.W.), Division of Hematology/Oncology, Department of Medicine (F.M.H., A.T.P.), Department of Public Health Sciences (F.Z., D.H.), Department of Computer Science (M.L.), and Department of Radiology (K.K., G.S.K., H.A.), The University of Chicago, 5841 S Maryland Ave, MC 2000, Chicago, IL 60637; Department of Computer Science, Lagos State University, Lagos, Nigeria (B.S.A.).

Maksim Levental (M)

From the Center for Clinical Cancer Genetics and Global Health, Department of Medicine (O.J.O., A.E.W., T.F.Y., Y.Z., B.S.A., O.I.O.), Data Science Institute (A.E.W.), Division of Hematology/Oncology, Department of Medicine (F.M.H., A.T.P.), Department of Public Health Sciences (F.Z., D.H.), Department of Computer Science (M.L.), and Department of Radiology (K.K., G.S.K., H.A.), The University of Chicago, 5841 S Maryland Ave, MC 2000, Chicago, IL 60637; Department of Computer Science, Lagos State University, Lagos, Nigeria (B.S.A.).

Benjamin S Aribisala (BS)

From the Center for Clinical Cancer Genetics and Global Health, Department of Medicine (O.J.O., A.E.W., T.F.Y., Y.Z., B.S.A., O.I.O.), Data Science Institute (A.E.W.), Division of Hematology/Oncology, Department of Medicine (F.M.H., A.T.P.), Department of Public Health Sciences (F.Z., D.H.), Department of Computer Science (M.L.), and Department of Radiology (K.K., G.S.K., H.A.), The University of Chicago, 5841 S Maryland Ave, MC 2000, Chicago, IL 60637; Department of Computer Science, Lagos State University, Lagos, Nigeria (B.S.A.).

Kirti Kulkarni (K)

From the Center for Clinical Cancer Genetics and Global Health, Department of Medicine (O.J.O., A.E.W., T.F.Y., Y.Z., B.S.A., O.I.O.), Data Science Institute (A.E.W.), Division of Hematology/Oncology, Department of Medicine (F.M.H., A.T.P.), Department of Public Health Sciences (F.Z., D.H.), Department of Computer Science (M.L.), and Department of Radiology (K.K., G.S.K., H.A.), The University of Chicago, 5841 S Maryland Ave, MC 2000, Chicago, IL 60637; Department of Computer Science, Lagos State University, Lagos, Nigeria (B.S.A.).

Gregory S Karczmar (GS)

From the Center for Clinical Cancer Genetics and Global Health, Department of Medicine (O.J.O., A.E.W., T.F.Y., Y.Z., B.S.A., O.I.O.), Data Science Institute (A.E.W.), Division of Hematology/Oncology, Department of Medicine (F.M.H., A.T.P.), Department of Public Health Sciences (F.Z., D.H.), Department of Computer Science (M.L.), and Department of Radiology (K.K., G.S.K., H.A.), The University of Chicago, 5841 S Maryland Ave, MC 2000, Chicago, IL 60637; Department of Computer Science, Lagos State University, Lagos, Nigeria (B.S.A.).
ORCID: 0000-0002-2455-5858

Olufunmilayo I Olopade (OI)

From the Center for Clinical Cancer Genetics and Global Health, Department of Medicine (O.J.O., A.E.W., T.F.Y., Y.Z., B.S.A., O.I.O.), Data Science Institute (A.E.W.), Division of Hematology/Oncology, Department of Medicine (F.M.H., A.T.P.), Department of Public Health Sciences (F.Z., D.H.), Department of Computer Science (M.L.), and Department of Radiology (K.K., G.S.K., H.A.), The University of Chicago, 5841 S Maryland Ave, MC 2000, Chicago, IL 60637; Department of Computer Science, Lagos State University, Lagos, Nigeria (B.S.A.).
ORCID: 0000-0002-9936-1599

Hiroyuki Abe (H)

From the Center for Clinical Cancer Genetics and Global Health, Department of Medicine (O.J.O., A.E.W., T.F.Y., Y.Z., B.S.A., O.I.O.), Data Science Institute (A.E.W.), Division of Hematology/Oncology, Department of Medicine (F.M.H., A.T.P.), Department of Public Health Sciences (F.Z., D.H.), Department of Computer Science (M.L.), and Department of Radiology (K.K., G.S.K., H.A.), The University of Chicago, 5841 S Maryland Ave, MC 2000, Chicago, IL 60637; Department of Computer Science, Lagos State University, Lagos, Nigeria (B.S.A.).

Dezheng Huo (D)

From the Center for Clinical Cancer Genetics and Global Health, Department of Medicine (O.J.O., A.E.W., T.F.Y., Y.Z., B.S.A., O.I.O.), Data Science Institute (A.E.W.), Division of Hematology/Oncology, Department of Medicine (F.M.H., A.T.P.), Department of Public Health Sciences (F.Z., D.H.), Department of Computer Science (M.L.), and Department of Radiology (K.K., G.S.K., H.A.), The University of Chicago, 5841 S Maryland Ave, MC 2000, Chicago, IL 60637; Department of Computer Science, Lagos State University, Lagos, Nigeria (B.S.A.).
ORCID: 0000-0002-4041-1678

Classifications MeSH