Alcohol consumption promotes arsenic absorption but reduces tissue arsenic accumulation in mice.
Alcohol consumption
Arsenic speciation
Oral bioavailability
Tight junctions
Tissue accumulation
Journal
Eco-Environment & Health (Online)
ISSN: 2772-9850
Titre abrégé: Eco Environ Health
Pays: Netherlands
ID NLM: 9918713888506676
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
30
03
2023
revised:
11
06
2023
accepted:
25
06
2023
medline:
11
12
2023
pubmed:
11
12
2023
entrez:
11
12
2023
Statut:
epublish
Résumé
Alcohol consumption alters gut microflora and damages intestinal tight junction barriers, which may affect arsenic (As) oral bioavailability. In this study, mice were exposed to arsenate in the diet (6 μg/g) over a 3-week period and gavaged daily with Chinese liquor (0.05 or 0.10 mL per mouse per day). Following ingestion, 78.0% and 72.9% of the total As intake was absorbed and excreted via urine when co-exposed with liquor at daily doses of 0.05 or 0.10 mL, significantly greater than when As was supplied alone (44.7%). Alcohol co-exposure significantly altered gut microbiota but did not significantly alter As biotransformation in the intestinal tract or tissue. Significantly lower relative mRNA expression was observed for genes encoding for tight junctions in the ileum of liquor co-exposed mice, contributing to greater As bioavailability attributable to enhanced As absorption via the intestinal paracellular pathway. However, As concentration in the liver, kidney, and intestinal tissue of liquor-treated mice was decreased by 24.4%-42.6%, 27.5%-38.1%, and 28.1%-48.9% compared to control mice. This was likely due to greater renal glomerular filtration rate induced by alcohol, as suggested by significantly lower expression of genes encoding for renal tight junctions. In addition, in mice gavaged daily with 0.05 mL liquor, the serum antidiuretic hormone level was significantly lower than control mice (2.83 ± 0.59 vs. 5.40 ± 1.10 pg/mL), suggesting the diuretic function of alcohol consumption, which may facilitate As elimination via urine. These results highlight that alcohol consumption has a significant impact on the bioavailability and accumulation of As.
Identifiants
pubmed: 38074988
doi: 10.1016/j.eehl.2023.06.003
pii: S2772-9850(23)00031-5
pmc: PMC10702898
doi:
Types de publication
Journal Article
Langues
eng
Pagination
107-116Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Hongbo Li reports financial support was provided by 10.13039/501100001809National Natural Science Foundation of China and Jiangsu Agricultural Independent Innovation Program.
Références
Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9815-20
pubmed: 10449777
Environ Health Perspect. 2006 Dec;114(12):1826-31
pubmed: 17185270
Hepatology. 2009 Aug;50(2):638-44
pubmed: 19575462
Environ Sci Technol. 2017 Apr 18;51(8):4689-4696
pubmed: 28299926
Curr Opin Pediatr. 2008 Aug;20(4):448-52
pubmed: 18622203
Int J Mol Sci. 2020 Feb 03;21(3):
pubmed: 32028590
Environ Sci Technol. 2023 Jan 17;57(2):1017-1027
pubmed: 36580282
Lancet. 2018 Sep 22;392(10152):1015-1035
pubmed: 30146330
Environ Sci Technol. 2013 Jun 4;47(11):5613-8
pubmed: 23668419
Science. 2010 May 28;328(5982):1123-7
pubmed: 20508123
Environ Sci Technol. 2015 Sep 1;49(17):10675-81
pubmed: 26248026
Environ Health Perspect. 2014 Mar;122(3):284-91
pubmed: 24413286
Addiction. 2017 Jun;112(6):968-1001
pubmed: 28220587
Alcohol. 2008 Aug;42(5):349-61
pubmed: 18504085
Nat Commun. 2018 Dec 21;9(1):5424
pubmed: 30575732
Med Clin (Barc). 2022 Aug 12;159(3):139-146
pubmed: 35659417
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4485-93
pubmed: 25288760
Science. 2013 Aug 23;341(6148):866-8
pubmed: 23970694
Jpn Dent Sci Rev. 2017 Aug;53(3):78-85
pubmed: 28725298
Lancet. 2019 May 4;393(10183):1831-1842
pubmed: 30955975
Anaesthesia. 2004 Oct;59(10):993-1001
pubmed: 15488059
Am J Physiol Renal Physiol. 2009 Dec;297(6):F1566-74
pubmed: 19794110
J Physiol Biochem. 2014 Jun;70(2):341-53
pubmed: 24481563
Lancet. 2009 Jun 27;373(9682):2223-33
pubmed: 19560604
IARC Monogr Eval Carcinog Risks Hum. 2004;84:1-477
pubmed: 15645577
Adv Chronic Kidney Dis. 2011 Mar;18(2):85-90
pubmed: 21406292
Front Pharmacol. 2021 Mar 18;12:630557
pubmed: 33815111
Alcohol. 2008 Dec;42(8):675-82
pubmed: 19038698
Environ Sci Technol. 2018 Dec 18;52(24):14422-14435
pubmed: 30403856
Environ Health Perspect. 2011 Nov;119(11):1629-34
pubmed: 21749965
Biomed Pharmacother. 2005 Jan-Feb;59(1-2):30-7
pubmed: 15740933
J Appl Toxicol. 2011 Mar;31(2):95-107
pubmed: 21321970
Mayo Clin Proc. 2014 Sep;89(9):1201-10
pubmed: 25091872
Lancet. 1984 Jan 28;1(8370):179-82
pubmed: 6141332
Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20656-60
pubmed: 22143778
Toxicol Appl Pharmacol. 2001 May 1;172(3):249-61
pubmed: 11312654
Int J Clin Pract. 2020 Sep;74(9):e13539
pubmed: 32441853
Int J Mol Sci. 2020 Sep 03;21(17):
pubmed: 32899236
J Hepatol. 2000 May;32(5):742-7
pubmed: 10845660
Am J Med. 2016 Feb;129(2):180-186.e4
pubmed: 26524703
J Biol Chem. 2010 Apr 16;285(16):12037-46
pubmed: 20177070
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Environ Health Perspect. 2014 Aug;122(8):817-22
pubmed: 24833621
Int J Mol Med. 2014 Dec;34(6):1451-7
pubmed: 25319473
Environ Int. 2021 Jun;151:106444
pubmed: 33621917
Can J Gastroenterol Hepatol. 2020 Dec 17;2020:6629196
pubmed: 33381475
Am J Physiol Gastrointest Liver Physiol. 2004 Jun;286(6):G881-4
pubmed: 15132946
Nutrients. 2012 Jul;4(7):759-781
pubmed: 22852062
Chem Biol Interact. 1993 Sep;88(2-3):89-14
pubmed: 8403081
Environ Health Perspect. 2013 Mar;121(3):295-302
pubmed: 23458756
Food Res Int. 2020 Feb;128:108800
pubmed: 31955762
Aliment Pharmacol Ther. 2015 May;41(10):917-27
pubmed: 25809237
J Hepatol. 2019 Feb;70(2):260-272
pubmed: 30658727
Environ Health Perspect. 2016 Jul;124(7):890-9
pubmed: 26587579
Environ Sci Technol. 2019 Sep 17;53(18):10545-10559
pubmed: 31442034
Alcohol Clin Exp Res. 2003 Mar;27(3):388-95
pubmed: 12658104