SEM
Journal
APL bioengineering
ISSN: 2473-2877
Titre abrégé: APL Bioeng
Pays: United States
ID NLM: 101726398
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
07
07
2023
accepted:
14
11
2023
medline:
11
12
2023
pubmed:
11
12
2023
entrez:
11
12
2023
Statut:
epublish
Résumé
Modeling multiscale mechanics in shape-shifting engineered tissues, such as organoids and organs-on-chip, is both important and challenging. In fact, it is difficult to model relevant tissue-level large non-linear deformations mediated by discrete cell-level behaviors, such as migration and proliferation. One approach to solve this problem is subcellular element modeling (SEM), where ensembles of coarse-grained particles interacting via empirically defined potentials are used to model individual cells while preserving cell rheology. However, an explicit treatment of multiscale mechanics in SEM was missing. Here, we incorporated analyses and visualizations of particle level stress and strain in the open-source software SEM++ to create a new framework that we call subcellular element modeling and mechanics or SEM
Identifiants
pubmed: 38075209
doi: 10.1063/5.0166829
pii: 5.0166829
pmc: PMC10699888
doi:
Types de publication
Journal Article
Langues
eng
Pagination
046118Informations de copyright
© 2023 Author(s).
Déclaration de conflit d'intérêts
Alexander Stukowski and Constanze Kalcher are employed by OVITO GmbH which sells the software we used in the preparation of some of the figures.
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