Soft-metal(loid)s induce protein aggregation in
Escherichia coli
amino acid metabolism
anaerobiosis
protein aggregation
proteotoxicity
soft-metal(loid)s
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2023
2023
Historique:
received:
21
08
2023
accepted:
01
11
2023
medline:
11
12
2023
pubmed:
11
12
2023
entrez:
11
12
2023
Statut:
epublish
Résumé
Metal(loid) salts were used to treat infectious diseases in the past due to their exceptional biocidal properties at low concentrations. However, the mechanism of their toxicity has yet to be fully elucidated. The production of reactive oxygen species (ROS) has been linked to the toxicity of soft metal(loid)s such as Ag(I), Au(III), As(III), Cd(II), Hg(II), and Te(IV). Nevertheless, few reports have described the direct, or ROS-independent, effects of some of these soft-metal(loid)s on bacteria, including the dismantling of iron-sulfur clusters [4Fe-4S] and the accumulation of porphyrin IX. Here, we used genome-wide genetic, proteomic, and biochemical approaches under anaerobic conditions to evaluate the direct mechanisms of toxicity of these metal(loid)s in
Identifiants
pubmed: 38075883
doi: 10.3389/fmicb.2023.1281058
pmc: PMC10699150
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1281058Informations de copyright
Copyright © 2023 Cornejo, Muñoz-Villagrán, Luraschi, Sandoval-Díaz, Cancino, Pugin, Morales, Piotrowski, Sandoval, Vásquez and Arenas.
Déclaration de conflit d'intérêts
EM and JP were employed by E. & J. Gallo Winery. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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