Association between late-life air pollution exposure and medial temporal lobe atrophy in older women.
Journal
medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986
Informations de publication
Date de publication:
29 Nov 2023
29 Nov 2023
Historique:
medline:
11
12
2023
pubmed:
11
12
2023
entrez:
11
12
2023
Statut:
epublish
Résumé
Ambient air pollution exposures increase risk for Alzheimer's disease (AD) and related dementias, possibly due to structural changes in the medial temporal lobe (MTL). However, existing MRI studies examining exposure effects on the MTL were cross-sectional and focused on the hippocampus, yielding mixed results. To determine whether air pollution exposures were associated with MTL atrophy over time, we conducted a longitudinal study including 653 cognitively unimpaired community-dwelling older women from the Women's Health Initiative Memory Study with two MRI brain scans (MRI-1: 2005-6; MRI-2: 2009-10; M On average, MTL volume decreased by 0.53±1.00cm In summary, higher late-life PM First longitudinal study on air pollution and medial temporal lobe (MTL) volume. Late-life PM
Sections du résumé
Background
UNASSIGNED
Ambient air pollution exposures increase risk for Alzheimer's disease (AD) and related dementias, possibly due to structural changes in the medial temporal lobe (MTL). However, existing MRI studies examining exposure effects on the MTL were cross-sectional and focused on the hippocampus, yielding mixed results.
Method
UNASSIGNED
To determine whether air pollution exposures were associated with MTL atrophy over time, we conducted a longitudinal study including 653 cognitively unimpaired community-dwelling older women from the Women's Health Initiative Memory Study with two MRI brain scans (MRI-1: 2005-6; MRI-2: 2009-10; M
Results
UNASSIGNED
On average, MTL volume decreased by 0.53±1.00cm
Conclusion
UNASSIGNED
In summary, higher late-life PM
Highlights
UNASSIGNED
First longitudinal study on air pollution and medial temporal lobe (MTL) volume. Late-life PM
Identifiants
pubmed: 38077091
doi: 10.1101/2023.11.28.23298708
pmc: PMC10705610
pii:
doi:
Types de publication
Preprint
Langues
eng