The emerging role and therapeutic implications of bacterial and parasitic deubiquitinating enzymes.

autophagy and apoptosis deubiquitinating enzymes (DUBs) immune responses infection mechanisms ubiquitin

Journal

Frontiers in immunology

ISSN: 1664-3224

Titre abrégé: Front Immunol

Pays: Switzerland

ID NLM: 101560960

Informations de publication

Date de publication:
2023

Historique:

received: 27 09 2023

accepted: 03 11 2023

medline: 11 12 2023

pubmed: 11 12 2023

entrez: 11 12 2023

Statut: epublish

Résumé

Deubiquitinating enzymes (DUBs) are emerging as key factors for the infection of human cells by pathogens such as bacteria and parasites. In this review, we discuss the most recent studies on the role of deubiquitinase activity in exploiting and manipulating ubiquitin (Ub)-dependent host processes during infection. The studies discussed here highlight the importance of DUB host-pathogen research and underscore the therapeutic potential of inhibiting pathogen-specific DUB activity to prevent infectious diseases.

Identifiants

DOI: 10.3389/fimmu.2023.1303072 PMID: 38077335 PMC: PMC10703165

pubmed: 38077335

doi: 10.3389/fimmu.2023.1303072

pmc: PMC10703165

doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

Pagination

1303072

Informations de copyright

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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