Adoptive transfer of allergen-expressing B cells prevents IgE-mediated allergy.
allergy
cell therapy
chimerism
prophylaxis
tolerance
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
01
09
2023
accepted:
27
10
2023
medline:
11
12
2023
pubmed:
11
12
2023
entrez:
11
12
2023
Statut:
epublish
Résumé
Prophylactic strategies to prevent the development of allergies by establishing tolerance remain an unmet medical need. We previously reported that the transfer of autologous hematopoietic stem cells (HSC) expressing the major timothy grass pollen allergen, Phl p 5, on their cell surface induced allergen-specific tolerance in mice. In this study, we investigated the ability of allergen-expressing immune cells (dendritic cells, CD4 For this purpose, CD19 The transfer of purified Phl p 5-expressing CD19 Thus, we demonstrated that the transfer of Phl p 5-expressing CD19
Identifiants
pubmed: 38077381
doi: 10.3389/fimmu.2023.1286638
pmc: PMC10703460
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1286638Informations de copyright
Copyright © 2023 Prickler, Baranyi, Mengrelis, Weijler, Kainz, Kratzer, Steiner, Mucha, Rudoph, Pilat, Bohle, Strobl, Pickl, Valenta, Linhart and Wekerle.
Déclaration de conflit d'intérêts
RV received research grants from Worg Pharmaceuticals, Hangzhou, China; HVD Biotech, Vienna, Austria; and Viravaxx, Vienna, Austria. He serves as a consultant for Viravaxx and Worg. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
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