COVID-19 disease among children and young adults enrolled in the North American Pediatric Renal Trials and Collaborative Studies registry.
COVID-19
Chronic kidney disease
Dialysis
SARS-CoV-2
Transplant
Journal
Pediatric nephrology (Berlin, Germany)
ISSN: 1432-198X
Titre abrégé: Pediatr Nephrol
Pays: Germany
ID NLM: 8708728
Informations de publication
Date de publication:
May 2024
May 2024
Historique:
received:
21
07
2023
accepted:
21
11
2023
revised:
20
11
2023
medline:
18
3
2024
pubmed:
12
12
2023
entrez:
11
12
2023
Statut:
ppublish
Résumé
Coronavirus disease of 2019 (COVID-19) has disproportionately affected adults with kidney disease. Data regarding outcomes among children with kidney disease are limited. The North American Pediatric Renal Trials Collaborative Studies Registry (NAPRTCS) has followed children with chronic kidney disease (CKD) since 1987 at 87 participating centers. This study aimed to evaluate the impact of COVID-19 among participants enrolled in the three arms of the registry: CKD, dialysis, and transplant. This was a retrospective cohort study of COVID-19 among participants in the NAPRTCS CKD, dialysis, and transplant registries from 2020 to 2022. Where appropriate, t-tests, chi-square analyses, and univariate logistic regression were used to evaluate the data. The cohort included 1505 NAPRTCS participants with recent data entry; 260 (17%) had documented COVID-19. Infections occurred in all three registry arms, namely, 10% (n = 29) in CKD, 11% (n = 67) in dialysis, and 26% (n = 164) in transplant. The majority of participants (75%) were symptomatic. Hospitalizations occurred in 17% (n = 5) of participants with CKD, 27% (n = 18) maintenance dialysis participants, and 26% (n = 43) of transplant participants. Fourteen percent (n = 4) of CKD participants and 10% (n = 17) of transplant participants developed acute kidney injury (AKI), and a total of eight participants (one CKD, seven transplant) required dialysis initiation. Among transplant participants with moderate to severe illness, 40-43% developed AKI and 29-40% required acute dialysis. There were no reported deaths. COVID-19 was documented in 17% of active NAPRTCS participants. While there was no documented mortality, the majority of participants were symptomatic, and a quarter required hospitalization.
Sections du résumé
BACKGROUND
BACKGROUND
Coronavirus disease of 2019 (COVID-19) has disproportionately affected adults with kidney disease. Data regarding outcomes among children with kidney disease are limited. The North American Pediatric Renal Trials Collaborative Studies Registry (NAPRTCS) has followed children with chronic kidney disease (CKD) since 1987 at 87 participating centers. This study aimed to evaluate the impact of COVID-19 among participants enrolled in the three arms of the registry: CKD, dialysis, and transplant.
METHODS
METHODS
This was a retrospective cohort study of COVID-19 among participants in the NAPRTCS CKD, dialysis, and transplant registries from 2020 to 2022. Where appropriate, t-tests, chi-square analyses, and univariate logistic regression were used to evaluate the data.
RESULTS
RESULTS
The cohort included 1505 NAPRTCS participants with recent data entry; 260 (17%) had documented COVID-19. Infections occurred in all three registry arms, namely, 10% (n = 29) in CKD, 11% (n = 67) in dialysis, and 26% (n = 164) in transplant. The majority of participants (75%) were symptomatic. Hospitalizations occurred in 17% (n = 5) of participants with CKD, 27% (n = 18) maintenance dialysis participants, and 26% (n = 43) of transplant participants. Fourteen percent (n = 4) of CKD participants and 10% (n = 17) of transplant participants developed acute kidney injury (AKI), and a total of eight participants (one CKD, seven transplant) required dialysis initiation. Among transplant participants with moderate to severe illness, 40-43% developed AKI and 29-40% required acute dialysis. There were no reported deaths.
CONCLUSIONS
CONCLUSIONS
COVID-19 was documented in 17% of active NAPRTCS participants. While there was no documented mortality, the majority of participants were symptomatic, and a quarter required hospitalization.
Identifiants
pubmed: 38082091
doi: 10.1007/s00467-023-06241-0
pii: 10.1007/s00467-023-06241-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1459-1468Investigateurs
Michael Somers
(M)
Annabelle Chua
(A)
David Hooper
(D)
Gina-Marie Barletta
(GM)
Craig Belsha
(C)
Paul Brakeman
(P)
Priya Verghese
(P)
Meredith Atkinson
(M)
Bradley Warady
(B)
Sharon Bartosh
(S)
Rita Swinford
(R)
Rima Zahr
(R)
Tom Blydt-Hansen
(T)
Maha Haddad
(M)
Kathy Lee-Son
(K)
Lyndsay Harshman
(L)
Nadine Benador
(N)
Marissa DeFreitas
(M)
Kera Luckritz
(K)
Sahar Fathallah-Shaykh
(S)
Jillian Warejko
(J)
Joseph Flynn
(J)
Jennifer Jetton
(J)
Hiren Patel
(H)
Kimberly Czech
(K)
Carl Cramer
(C)
Amita Sharma
(A)
Ashton Chen
(A)
Margret Bock
(M)
Asha Moudgil
(A)
Rachel Milner
(R)
Raoul Nelson
(R)
Kelsey Richardson
(K)
Marcela Del Rio
(M)
Rita Sheth
(R)
Deborah Kees-Folts
(D)
Siddarth Shah
(S)
Katherine Dell
(K)
Sarah Swartz
(S)
Elizabeth Hunt
(E)
Sharon Andreoli
(S)
Christina Nguyen
(C)
Dechu Puliyanda
(D)
Benjamin Laskin
(B)
Carlos Araya
(C)
Scott Sutherland
(S)
Robert Woroniecki
(R)
Maury Pinsk
(M)
Erin Rademacher
(E)
Diego Aviles
(D)
Syed Kamal
(S)
Amy Staples
(A)
Kenneth Lieberman
(K)
Janusz Feber
(J)
Samhar Al-Akash
(S)
Jorge Ramirez
(J)
Daniel McKenney
(D)
Alexandru Constantinescu
(A)
Deogracias Pena
(D)
Julia Steinke
(J)
Yi Cai
(Y)
Jason Thomas
(J)
Informations de copyright
© 2023. The Author(s), under exclusive licence to International Pediatric Nephrology Association.
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