Study of the Antihypertensive Effect of Scorzonera undulata ssp. deliciosa in Albino Wistar Rats.
ACE-2.
Aortic ring
Hypertension
Medicinal plant
Receptor-operated calcium channels
Scorzonera undulata
Vasodilation
Journal
Cardiovascular & hematological agents in medicinal chemistry
ISSN: 1875-6182
Titre abrégé: Cardiovasc Hematol Agents Med Chem
Pays: Netherlands
ID NLM: 101266881
Informations de publication
Date de publication:
11 Dec 2023
11 Dec 2023
Historique:
received:
31
01
2023
revised:
12
07
2023
accepted:
07
08
2023
medline:
12
12
2023
pubmed:
12
12
2023
entrez:
12
12
2023
Statut:
aheadofprint
Résumé
The study aimed to investigate the antihypertensive activity of Scorzonera undulata ssp. deliciosa. Scorzonera undulata ssp deliciosa, locally known as "Guiz", is used in traditional medicine in Morocco as a diuretic and mainly against snake bites. This study investigated the possible antihypertensive effect of the aqueous extract of Scorzonera undulata (AESU). In the present study, the antihypertensive activity of AESU AUSU was tested in normotensive and hypertensive rats. The results indicated that AESU decreased the systolic, diastolic, and mean arterial blood pressure in hypertensive rats. The data revealed that AESU exerted its antihypertensive effect through vasodilatory properties. Interestingly, the study demonstrated that the vasorelaxation ability of AESU might be mediated through receptor-operated calcium channels (ROCCs). However, AESU dhad effect on inhibiting ACE-2. The present study indicates the antihypertensive and vasorelaxant activities of AESU in hypertensive rats.
Sections du résumé
AIMS
OBJECTIVE
The study aimed to investigate the antihypertensive activity of Scorzonera undulata ssp. deliciosa.
BACKGROUND
BACKGROUND
Scorzonera undulata ssp deliciosa, locally known as "Guiz", is used in traditional medicine in Morocco as a diuretic and mainly against snake bites.
OBJECTIVE
OBJECTIVE
This study investigated the possible antihypertensive effect of the aqueous extract of Scorzonera undulata (AESU).
MATERIAL AND METHODS
METHODS
In the present study, the antihypertensive activity of AESU AUSU was tested in normotensive and hypertensive rats.
RESULTS
RESULTS
The results indicated that AESU decreased the systolic, diastolic, and mean arterial blood pressure in hypertensive rats. The data revealed that AESU exerted its antihypertensive effect through vasodilatory properties. Interestingly, the study demonstrated that the vasorelaxation ability of AESU might be mediated through receptor-operated calcium channels (ROCCs). However, AESU dhad effect on inhibiting ACE-2.
CONCLUSION
CONCLUSIONS
The present study indicates the antihypertensive and vasorelaxant activities of AESU in hypertensive rats.
Identifiants
pubmed: 38083883
pii: CHAMC-EPUB-136634
doi: 10.2174/0118715257243190231024164358
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
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