Cytotoxic withanolides from the leaves of Datura stramonium L.
Cytotoxicity * Datura stramonium L. * Withanolides * Withastramonolides A-F * structural elucidation
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
12 Dec 2023
12 Dec 2023
Historique:
revised:
09
12
2023
received:
20
10
2023
accepted:
11
12
2023
medline:
12
12
2023
pubmed:
12
12
2023
entrez:
12
12
2023
Statut:
aheadofprint
Résumé
Six novel withanolides, along with nine known related compounds were isolated from the leaves of Datura stramonium L. The structures and absolute configurations of the new withanolides were elucidated by employing various spectral techniques and comparing them with those previously reported in the literature. In addition, four withanolides demonstrated interesting cytotoxic activity on LN229 cells with IC50<20 μM.
Identifiants
pubmed: 38084071
doi: 10.1002/cbdv.202301655
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202301655Informations de copyright
© 2023 Wiley-VCH GmbH.