PER2 regulates odontoblastic differentiation of dental papilla cells
ATP
Dental papilla cells
In vitro
Odontoblastic differentiation
PER2
ROS
Tooth development
Journal
PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425
Informations de publication
Date de publication:
2023
2023
Historique:
received:
19
07
2023
accepted:
29
10
2023
medline:
12
12
2023
pubmed:
12
12
2023
entrez:
12
12
2023
Statut:
epublish
Résumé
Dental papilla cells (DPCs) are one of the key stem cells for tooth development, eventually forming dentin and pulp. Previous studies have reported that PER2 is expressed in a 24-hour oscillatory pattern in DPCs We monitored the expression of PER2 in DPCs differentiated PER2 expression was considerably elevated throughout the odontoblastic differentiation of DPCs Overall, we demonstrated that PER2 positively regulates the odontogenic differentiation of DPCs, and the mechanism may be related to mitochondrial function as shown by intracellular ATP content and ROS levels.
Sections du résumé
Background
UNASSIGNED
Dental papilla cells (DPCs) are one of the key stem cells for tooth development, eventually forming dentin and pulp. Previous studies have reported that PER2 is expressed in a 24-hour oscillatory pattern in DPCs
Methods
UNASSIGNED
We monitored the expression of PER2 in DPCs differentiated
Results
UNASSIGNED
PER2 expression was considerably elevated throughout the odontoblastic differentiation of DPCs
Conclusion
UNASSIGNED
Overall, we demonstrated that PER2 positively regulates the odontogenic differentiation of DPCs, and the mechanism may be related to mitochondrial function as shown by intracellular ATP content and ROS levels.
Identifiants
pubmed: 38084142
doi: 10.7717/peerj.16489
pii: 16489
pmc: PMC10710777
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e16489Informations de copyright
©2023 Ma et al.
Déclaration de conflit d'intérêts
The authors declare there are no competing interests.
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