Evaluation of curcumin for dermatologic conditions: a systematic review.
Curcumin
Natural
Oral lichen planus
Psoriasis
Radiation dermatitis
Turmeric
Journal
Archives of dermatological research
ISSN: 1432-069X
Titre abrégé: Arch Dermatol Res
Pays: Germany
ID NLM: 8000462
Informations de publication
Date de publication:
12 Dec 2023
12 Dec 2023
Historique:
received:
17
08
2023
accepted:
16
09
2023
revised:
17
08
2023
medline:
12
12
2023
pubmed:
12
12
2023
entrez:
12
12
2023
Statut:
epublish
Résumé
There is increasing demand for natural and sustainable products for the treatment of dermatologic conditions. This systematic review aims to critically analyze published randomized controlled trials (RCTs) and provide evidence-based recommendations on the therapeutic use of curcumin for a variety of dermatological diseases. A systematic search of published literature was performed on July 18, 2023 using PRISMA guidelines for turmeric or curcumin for the treatment of skin diseases. Clinical recommendations were made based on the Oxford Centre for Evidence-Based Medicine guidelines. We identified 18 original randomized controlled trials for use of turmeric or curcumin for psoriasis, radiation dermatitis, oral lichen planus, pruritis, vitiligo, tinea capitis, facial erythema, and scarring. Psoriasis, cesarean section scar, and pruritus received grade of recommendation B. Radiation dermatitis, oral lichen planus, vitiligo, tinea capitis, and facial redness received grade of recommendation C or D. Curcumin was demonstrated to have an excellent safety profile in all clinical trials analyzed. Further research is required to determine optimal dosing and treatment parameters of turmeric. Additional, larger, RCTs and non-RCTs should be conducted to further investigate the safety and efficacy of curcumin as a treatment option for dermatological diseases.
Identifiants
pubmed: 38085369
doi: 10.1007/s00403-023-02754-8
pii: 10.1007/s00403-023-02754-8
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
37Informations de copyright
© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
Références
Oxford Centre for Evidence-Based Medicine: Levels of Evidence (March 2009). Centre for Evidence Based Medicine 2009 [cited 2023 August 7]
Abdullah EM et al (2022) Photodynamic therapy of tinea capitis in children using curcumin loaded in nanospanlastics: a randomized controlled comparative clinical study. J Drug Delivery Sci Technol 74:103496
doi: 10.1016/j.jddst.2022.103496
Amirchaghmaghi M et al (2016) Evaluation of the efficacy of curcumin in the treatment of oral lichen planus: a randomized controlled trial. J Clin Diagn Res 10(5):ZC134–ZC137
pubmed: 27437348
pmcid: 4948524
Antiga E et al (2015) Oral curcumin (Meriva) is effective as an adjuvant treatment and is able to reduce IL-22 serum levels in patients with psoriasis vulgaris. Biomed Res Int 2015:283634
doi: 10.1155/2015/283634
pubmed: 26090395
pmcid: 4450233
Bahraini P et al (2018) Turmeric tonic as a treatment in scalp psoriasis: a randomized placebo-control clinical trial. J Cosmet Dermatol 17(3):461–466
doi: 10.1111/jocd.12513
pubmed: 29607625
Bilia AR et al (2018) Curcumin nanoparticles potentiate therapeutic effectiveness of acitrein in moderate-to-severe psoriasis patients and control serum cholesterol levels. J Pharm Pharmacol 70(7):919–928
doi: 10.1111/jphp.12910
pubmed: 29600580
Buhrmann C et al (2011) Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem 286(32):28556–28566
doi: 10.1074/jbc.M111.256180
pubmed: 21669872
pmcid: 3151097
Carrion-Gutierrez M et al (2015) Effects of Curcuma extract and visible light on adults with plaque psoriasis. Eur J Dermatol 25(3):240–246
doi: 10.1684/ejd.2015.2584
pubmed: 26066761
Castelo-Soccio L, Van Voorhees AS (2009) Long-term efficacy of biologics in dermatology. Dermatol Ther 22(1):22–33
doi: 10.1111/j.1529-8019.2008.01213.x
pubmed: 19222514
pmcid: 2880851
Chainani-Wu N (2003) Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med 9(1):161–168
doi: 10.1089/107555303321223035
pubmed: 12676044
Chainani-Wu N et al (2012) High-dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planus. J Am Acad Dermatol 66(5):752–760
doi: 10.1016/j.jaad.2011.04.022
pubmed: 21907450
El-Saadony MT et al (2022) Impacts of turmeric and its principal bioactive curcumin on human health: Pharmaceutical, medicinal, and food applications: a comprehensive review. Front Nutr 9:1040259
doi: 10.3389/fnut.2022.1040259
pubmed: 36712505
Gorabi AM et al (2021) Effect of curcumin on proinflammatory cytokines: a meta-analysis of randomized controlled trials. Cytokine 143:155541
doi: 10.1016/j.cyto.2021.155541
pubmed: 33934954
Hewlings SJ, Kalman DS (2017) Curcumin: a review of its effects on human health. Foods 6(10):92
doi: 10.3390/foods6100092
pubmed: 29065496
pmcid: 5664031
Hodgens A, Sharman T (2023) Corticosteroids, in StatPearls. Treasure Island (FL)
Iacovelli NA et al (2020) Topical treatment of radiation-induced dermatitis: current issues and potential solutions. Drugs Context 9:1–13
doi: 10.7573/dic.2020-4-7
Jalalmanesh S et al (2022) Therapeutic effects of turmeric topical cream in vitiligo: a randomized, double-blind, placebo-controlled pilot study. J Cosmet Dermatol 21(10):4454–4461
doi: 10.1111/jocd.14814
pubmed: 35104042
Jiang Y et al (2023) Curcumin inhibits the pruritus in mice through mast cell MrgprB2 receptor. Inflamm Res 72(5):933–945
doi: 10.1007/s00011-023-01724-0
pubmed: 36997814
Kia SJ et al (2020) Comparison of oral nano-curcumin with oral prednisolone on oral lichen planus: a randomized double-blinded clinical trial. BMC Complement Med Ther 20(1):328
doi: 10.1186/s12906-020-03128-7
pubmed: 33129289
pmcid: 7603687
Lao CD et al (2006) Dose escalation of a curcuminoid formulation. BMC Complement Altern Med 6:10
doi: 10.1186/1472-6882-6-10
pubmed: 16545122
pmcid: 1434783
Mahmudi G et al (2015) The impact of turmeric cream on healing of Caesarean Scar. West Indian Med J 64(4):400–406
pubmed: 26624595
Menon VP, Sudheer AR (2007) Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol 595:105–125
doi: 10.1007/978-0-387-46401-5_3
pubmed: 17569207
Mollazadeh H et al (2019) Immune modulation by curcumin: the role of interleukin-10. Crit Rev Food Sci Nutr 59(1):89–101
doi: 10.1080/10408398.2017.1358139
pubmed: 28799796
Nelson KM et al (2017) The essential medicinal chemistry of curcumin. J Med Chem 60(5):1620–1637
doi: 10.1021/acs.jmedchem.6b00975
pubmed: 28074653
pmcid: 5346970
Otero ME et al (2015) A pilot study on the Psoriasis Area and Severity Index (PASI) for small areas: presentation and implications of the Low PASI score. J Dermatolog Treat 26(4):314–317
doi: 10.3109/09546634.2014.972316
pubmed: 25275934
Pakfetrat M et al (2014) Effects of turmeric on uremic pruritus in end stage renal disease patients: a double-blind randomized clinical trial. J Nephrol 27(2):203–207
doi: 10.1007/s40620-014-0039-2
pubmed: 24482090
Panahi Y et al (2012) Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial. Br J Nutr 108(7):1272–1279
doi: 10.1017/S0007114511006544
pubmed: 22099425
Ryan JL et al (2013) Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiat Res 180(1):34–43
doi: 10.1667/RR3255.1
pubmed: 23745991
pmcid: 3998827
Ryan Wolf J et al (2020) Utility of topical agents for radiation dermatitis and pain: a randomized clinical trial. Support Care Cancer 28(7):3303–3311
doi: 10.1007/s00520-019-05166-5
pubmed: 31758326
Ryan Wolf J et al (2018) Oral curcumin for radiation dermatitis: a URCC NCORP study of 686 breast cancer patients. Support Care Cancer 26(5):1543–1552
doi: 10.1007/s00520-017-3957-4
pubmed: 29192329
Sarafian G et al (2015) Topical turmeric microemulgel in the management of plaque psoriasis; a clinical evaluation. Iran J Pharm Res 14(3):865–876
pubmed: 26330875
pmcid: 4518115
Schallreuter KU, Rokos H (2006) Turmeric (curcumin): a widely used curry ingredient, can contribute to oxidative stress in Asian patients with acute vitiligo. Indian J Dermatol Venereol Leprol 72(1):57–59
doi: 10.4103/0378-6323.19722
pubmed: 16481714
Sharifi-Rad J et al (2020) Turmeric and its major compound curcumin on health: bioactive effects and safety profiles for food, pharmaceutical, biotechnological and medicinal applications. Front Pharmacol 11:01021
doi: 10.3389/fphar.2020.01021
pubmed: 33041781
pmcid: 7522354
Talakesh T et al (2022) Effect of nano-curcumin on radiotherapy-induced skin reaction in breast cancer patients: a randomized, triple-blind, placebo-controlled trial. Curr Radiopharm 15(4):332–340
doi: 10.2174/1874471015666220623104316
pubmed: 35747962
Vaughn AR et al (2019) Dietary supplementation with turmeric polyherbal formulation decreases facial redness: a randomized double-blind controlled pilot study. J Integr Med 17(1):20–23
doi: 10.1016/j.joim.2018.11.004
pubmed: 30527287
Zhang Z et al (2023) Preparation, properties and interaction of curcumin loaded zein/HP-beta-CD nanoparticles based on electrostatic interactions by antisolvent co-precipitation. Food Chem 403:134344
doi: 10.1016/j.foodchem.2022.134344
pubmed: 36183473
Zito PM, Mazzoni T (2023) Acitretin, in StatPearls. Treasure Island (FL)