T cell-mediated curation and restructuring of tumor tissue coordinates an effective immune response.

CODEX CP: Cancer CP: Immunology Multiplexed tissue imaging T cell phenotype T cell therapy T cells cancer immunotherapy checkpoint inhibitor therapy melanoma metabolism spatial biology

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
11 Dec 2023
Historique:
received: 10 01 2023
revised: 06 09 2023
accepted: 10 11 2023
medline: 12 12 2023
pubmed: 12 12 2023
entrez: 12 12 2023
Statut: aheadofprint

Résumé

Antigen-specific T cells traffic to, are influenced by, and create unique cellular microenvironments. Here we characterize these microenvironments over time with multiplexed imaging in a melanoma model of adoptive T cell therapy and human patients with melanoma treated with checkpoint inhibitor therapy. Multicellular neighborhood analysis reveals dynamic immune cell infiltration and inflamed tumor cell neighborhoods associated with CD8

Identifiants

DOI: 10.1016/j.celrep.2023.113494 PMID: 38085642
pubmed: 38085642
pii: S2211-1247(23)01506-1
doi: 10.1016/j.celrep.2023.113494
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113494

Informations de copyright

Copyright © 2023. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of interests G.P.N. has equity in and is a scientific advisory board member of Akoya Biosciences, Inc. A.J.R. is an advisor for Affini-T Therapeutics. G.P.N. and J.W.H. share a patent related to this work. The other authors declare no competing interests.

Auteurs

John W Hickey (JW)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Maximillian Haist (M)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Nina Horowitz (N)

Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

Chiara Caraccio (C)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Yuqi Tan (Y)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Andrew J Rech (AJ)

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Marc-Andrea Baertsch (MA)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Xavier Rovira-Clavé (X)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Bokai Zhu (B)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Gustavo Vazquez (G)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Graham Barlow (G)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Eran Agmon (E)

Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Center for Cell Analysis and Modeling, University of Connecticut Health, Farmington, CT 06032, USA.

Yury Goltsev (Y)

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

John B Sunwoo (JB)

Department of Otolaryngology, Head and Neck Surgery, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Markus Covert (M)

Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

Garry P Nolan (GP)

Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: gnolan@stanford.edu.

Classifications MeSH