Time to disability milestones and annualized relapse rates in NMOSD and MOGAD.

Journal

Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449

Informations de publication

Date de publication:
12 Dec 2023
Historique:
revised: 07 12 2023
received: 08 09 2023
accepted: 08 12 2023
medline: 13 12 2023
pubmed: 13 12 2023
entrez: 12 12 2023
Statut: aheadofprint

Résumé

To investigate accumulation of disability in neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein-antibody-associated disease (MOGAD) in a changing treatment landscape. We aimed to identify risk factors for the development of disability milestones in relation to disease duration, number of attacks, and age. We analyzed data from individuals with NMOSD and MOGAD from the German Neuromyelitis Optica Study Group registry. Applying survival analyses, we estimated risk factors and computed time to disability milestones as defined by the EDSS. We included 483 patients: 298 AQP4-IgG AQP4-IgG

Identifiants

DOI: 10.1002/ana.26858 PMID: 38086777
pubmed: 38086777
doi: 10.1002/ana.26858
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

This article is protected by copyright. All rights reserved.

Auteurs

Ankelien Duchow (A)

Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.

Judith Bellmann-Strobl (J)

Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.

Tim Friede (T)

Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.
ORCID: 0000-0001-5347-7441

Orhan Aktas (O)

Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Klemens Angstwurm (K)

Department of Neurology, University of Regensburg, Regensburg, Germany.

Ilya Ayzenberg (I)

Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.

Achim Berthele (A)

Department of Neurology, School of Medicine, Technical University Munich, Klinikum rechts der Isar, Munich, Germany.

Eva Dawin (E)

Department of Neurology with Institute of translational Neurology, University of Münster, Münster, Germany.

Daniel Engels (D)

Institute of Clinical Neuroimmunology, LMU Hospital, Ludwig-Maximilians University Munich, Munich, Germany.
ORCID: 0000-0002-9877-6987

Katinka Fischer (K)

Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Martina Flaskamp (M)

Department of Neurology, School of Medicine, Technical University Munich, Klinikum rechts der Isar, Munich, Germany.

Katrin Giglhuber (K)

Department of Neurology, School of Medicine, Technical University Munich, Klinikum rechts der Isar, Munich, Germany.

Matthias Grothe (M)

Department of Neurology, University of Greifswald, Greifswald, Germany.
ORCID: 0000-0002-7998-5310

Joachim Havla (J)

Institute of Clinical Neuroimmunology, LMU Hospital, Ludwig-Maximilians University Munich, Munich, Germany.

Martin W Hümmert (MW)

Department of Neurology, Hannover Medical School, Hannover, Germany.

Sven Jarius (S)

Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Heidelberg, Germany.

Matthias Kaste (M)

Department of Neurology, Nordwest Hospital Sanderbusch, Sande, Germany.

Peter Kern (P)

Department of Neurology, Asklepios Expert Clinic Teupitz, Teupitz, Germany.

Ingo Kleiter (I)

Marianne-Strauß-Klinik, Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg, Germany.

Luisa Klotz (L)

Department of Neurology with Institute of translational Neurology, University of Münster, Münster, Germany.

Mirjam Korporal-Kuhnke (M)

Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Heidelberg, Germany.

Markus Kraemer (M)

Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Department of Neurology, Alfried Krupp Hospital, Essen, Germany.

Markus Krumbholz (M)

Department of Neurology and Pain Treatment, Multiple Sclerosis Center, Center for Translational Medicine, Immanuel Klinik Rüdersdorf, University Hospital of the Brandenburg Medical School Theodor Fontane, Rüdersdorf bei Berlin, Germany.
Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Rüdersdorf bei Berlin, Germany.
Department of Neurology & Stroke, University Hospital of Tübingen, Tübingen, Germany.

Tania Kümpfel (T)

Institute of Clinical Neuroimmunology, LMU Hospital, Ludwig-Maximilians University Munich, Munich, Germany.
ORCID: 0000-0001-7509-5268

Lisa Lohmann (L)

Department of Neurology with Institute of translational Neurology, University of Münster, Münster, Germany.
ORCID: 0000-0003-4911-6883

Marius Ringelstein (M)

Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Department of Neurology, Centre for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
ORCID: 0000-0003-3618-8407

Paulus Rommer (P)

Department of Neurology, Medical University of Vienna, Vienna, Austria.
Department of Neurology, Rostock University Medical Center, Rostock, Germany.

Patrick Schindler (P)

Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.

Charlotte Schubert (C)

Department of Neurology, Rostock University Medical Center, Rostock, Germany.

Carolin Schwake (C)

Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.

Makbule Senel (M)

Department of Neurology, University of Ulm, Ulm, Germany.
ORCID: 0000-0002-2737-7495

Florian Then Bergh (FT)

Department of Neurology, University of Leipzig, Leipzig, Germany.

Daria Tkachenko (D)

Department of Neurology, Hannover Medical School, Hannover, Germany.

Hayrettin Tumami (H)

Department of Neurology, University of Ulm, Ulm, Germany.

Corinna Trebst (C)

Department of Neurology, Hannover Medical School, Hannover, Germany.

Ioannis Vardakas (I)

Department of Neurology, University of Ulm, Ulm, Germany.

Annette Walter (A)

Department of Neurology, Herford Hospital, Herford, Germany.

Clemens Warnke (C)

Department of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Germany.
ORCID: 0000-0002-3510-9255

Martin S Weber (MS)

Institute of Neuropathology, Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology, Göttingen, Germany.
ORCID: 0000-0001-8409-0389

Jonathan Wickel (J)

Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena, Germany.

Brigitte Wildemann (B)

Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Heidelberg, Germany.

Alexander Winkelmann (A)

Department of Neurology, Rostock University Medical Center, Rostock, Germany.

Friedemann Paul (F)

Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
ORCID: 0000-0002-6378-0070

Jan-Patrick Stellmann (JP)

Department of Neurology and Institute of Neuroimmunology and MS (INIMS), University Medical Center Hamburg -Eppendorf, Hamburg, Germany.
APHM, Hopital de la Timone, CEMEREM, Marseille, France.
Aix Marseille Univ, CNRS, CRMBM, Marseille, France.

Vivien Häußler (V)

Department of Neurology and Institute of Neuroimmunology and MS (INIMS), University Medical Center Hamburg -Eppendorf, Hamburg, Germany.
ORCID: 0000-0002-7787-7391

Classifications MeSH