Role of CD68 in the tumor immune microenvironment in Hodgkin's lymphoma.

Despite the high rate of cure in classical Hodgkin Lymphoma (cHL), some patients experienced a refractory disease, sometimes, hardly curable. In the pathogenesis of cHL, Reed Sternberg Cells (HRSC), which represent only less than 1% of tumor cells, are not the only protagonist; infact, the role of tumor microenvironment is essential in survival, tumor growth and progression of the disease due to the interaction between immune cells, chemokines, and cytokines. In this review the current significant literature was discussed. Many studies demonstrated the role of macrophages CD68+ as We can suggest that a high baseline CD68 macrophages in cHL patients could contribute to the identification of high-risk patients and help clinician to choose the best treatment, in the context of refractory disease. A macrophages target strategy in associations with chemotherapy or biological therapy could represent a promising approach for future studies and investigations.