Physiology of γ-aminobutyric acid production by

Akkermansia muciniphila GABA acid stress tolerance glutamate decarboxylase gut microbiota γ-aminobutyric acid

Journal

Applied and environmental microbiology
ISSN: 1098-5336
Titre abrégé: Appl Environ Microbiol
Pays: United States
ID NLM: 7605801

Informations de publication

Date de publication:
24 Jan 2024
Historique:
pubmed: 13 12 2023
medline: 13 12 2023
entrez: 13 12 2023
Statut: ppublish

Résumé

Gut bacteria hold the potential to produce a broad range of metabolites that can modulate human functions, including molecules with neuroactive potential. One such molecule is γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter of the central nervous system in animals. Metagenomic analyses suggest that the genomes of many gut bacteria encode glutamate decarboxylase (GAD), the enzyme that catalyzes GABA production. The genome of

Identifiants

pubmed: 38088552
doi: 10.1128/aem.01121-23
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0112123

Subventions

Organisme : Soehngen Institute of Anaerobic Microbiology (SIAM)
ID : 024.00.002
Organisme : Eat2beNICE
ID : Union's Horizon 2020 grant

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Auteurs

Prokopis Konstanti (P)

Laboratory of Microbiology, Wageningen University & Research, Wageningen, the Netherlands.

Kate Ligthart (K)

Laboratory of Microbiology, Wageningen University & Research, Wageningen, the Netherlands.

Christos Fryganas (C)

Food Quality and Design, Wageningen University & Research, Wageningen, the Netherlands.

Patinios Constantinos (P)

Laboratory of Microbiology, Wageningen University & Research, Wageningen, the Netherlands.

Hauke Smidt (H)

Laboratory of Microbiology, Wageningen University & Research, Wageningen, the Netherlands.

Willem M de Vos (WM)

Laboratory of Microbiology, Wageningen University & Research, Wageningen, the Netherlands.
Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Clara Belzer (C)

Laboratory of Microbiology, Wageningen University & Research, Wageningen, the Netherlands.

Classifications MeSH