Physiology of γ-aminobutyric acid production by
Akkermansia muciniphila
GABA
acid stress tolerance
glutamate decarboxylase
gut microbiota
γ-aminobutyric acid
Journal
Applied and environmental microbiology
ISSN: 1098-5336
Titre abrégé: Appl Environ Microbiol
Pays: United States
ID NLM: 7605801
Informations de publication
Date de publication:
24 Jan 2024
24 Jan 2024
Historique:
pubmed:
13
12
2023
medline:
13
12
2023
entrez:
13
12
2023
Statut:
ppublish
Résumé
Gut bacteria hold the potential to produce a broad range of metabolites that can modulate human functions, including molecules with neuroactive potential. One such molecule is γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter of the central nervous system in animals. Metagenomic analyses suggest that the genomes of many gut bacteria encode glutamate decarboxylase (GAD), the enzyme that catalyzes GABA production. The genome of
Identifiants
pubmed: 38088552
doi: 10.1128/aem.01121-23
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0112123Subventions
Organisme : Soehngen Institute of Anaerobic Microbiology (SIAM)
ID : 024.00.002
Organisme : Eat2beNICE
ID : Union's Horizon 2020 grant
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.