Indigenous Australian genomes show deep structure and rich novel variation.

Journal

Nature

ISSN: 1476-4687

Titre abrégé: Nature

Pays: England

ID NLM: 0410462

Informations de publication

Date de publication:
13 Dec 2023

Historique:

received: 29 11 2022

accepted: 03 11 2023

medline: 14 12 2023

pubmed: 14 12 2023

entrez: 13 12 2023

Statut: aheadofprint

Résumé

The Indigenous peoples of Australia have a rich linguistic and cultural history. How this relates to genetic diversity remains largely unknown because of their limited engagement with genomic studies. Here we analyse the genomes of 159 individuals from four remote Indigenous communities, including people who speak a language (Tiwi) not from the most widespread family (Pama-Nyungan). This large collection of Indigenous Australian genomes was made possible by careful community engagement and consultation. We observe exceptionally strong population structure across Australia, driven by divergence times between communities of 26,000-35,000 years ago and long-term low but stable effective population sizes. This demographic history, including early divergence from Papua New Guinean (47,000 years ago) and Eurasian groups

Identifiants

DOI: 10.1038/s41586-023-06831-w PMID: 38093005

pubmed: 38093005

doi: 10.1038/s41586-023-06831-w

pii: 10.1038/s41586-023-06831-w

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Investigateurs

Ashley Farlow (A)

Azure Hermes (A)

Hardip R Patel (HR)

Sharon Huebner (S)

Gareth Baynam (G)

Misty R Jenkins (MR)

Simon Easteal (S)

Stephen Leslie (S)

Informations de copyright

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