Strain on Scarce Intensive Care Beds Drives Reduced Patient Volumes, Patient Selection, and Worse Outcome: A National Cohort Study.


Journal

Critical care medicine
ISSN: 1530-0293
Titre abrégé: Crit Care Med
Pays: United States
ID NLM: 0355501

Informations de publication

Date de publication:
14 Dec 2023
Historique:
medline: 14 12 2023
pubmed: 14 12 2023
entrez: 14 12 2023
Statut: aheadofprint

Résumé

Strain on ICUs during the COVID-19 pandemic required stringent triage at the ICU to distribute resources appropriately. This could have resulted in reduced patient volumes, patient selection, and worse outcome of non-COVID-19 patients, especially during the pandemic peaks when the strain on ICUs was extreme. We analyzed this potential impact on the non-COVID-19 patients. A national cohort study. Data of 71 Dutch ICUs. A total of 120,393 patients in the pandemic non-COVID-19 cohort (from March 1, 2020 to February 28, 2022) and 164,737 patients in the prepandemic cohort (from January 1, 2018 to December 31, 2019). None. Volume, patient characteristics, and mortality were compared between the pandemic non-COVID-19 cohort and the prepandemic cohort, focusing on the pandemic period and its peaks, with attention to strata of specific admission types, diagnoses, and severity. The number of admitted non-COVID-19 patients during the pandemic period and its peaks were, respectively, 26.9% and 34.2% lower compared with the prepandemic cohort. The pandemic non-COVID-19 cohort consisted of fewer medical patients (48.1% vs. 50.7%), fewer patients with comorbidities (36.5% vs. 40.6%), and more patients on mechanical ventilation (45.3% vs. 42.4%) and vasoactive medication (44.7% vs. 38.4%) compared with the prepandemic cohort. Case-mix adjusted mortality during the pandemic period and its peaks was higher compared with the prepandemic period, odds ratios were, respectively, 1.08 (95% CI, 1.05-1.11) and 1.10 (95% CI, 1.07-1.13). In non-COVID-19 patients the strain on healthcare has driven lower patient volume, selection of fewer comorbid patients who required more intensive support, and a modest increase in the case-mix adjusted mortality.

Identifiants

pubmed: 38095502
doi: 10.1097/CCM.0000000000006156
pii: 00003246-990000000-00249
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and Wolters Kluwer Health, Inc.

Déclaration de conflit d'intérêts

Dr. Brinkman received funding from the National Intensive Care Evaluation (NICE) Foundation. Drs. de Keizer and Termorshuizen institutions received funding from the NICE Foundation. Dr. Termorshuizen received funding from the Mental Health Care Institute Rivierduinen, Leiden. The remaining authors have disclosed that they do not have any potential conflicts of interest.

Références

Rhodes A, Ferdinande P, Flaatten H, et al.: The variability of critical care bed numbers in Europe. Intensive Care Med 2012; 38:1647–1653
Dutch COVID-19 Research Consortium: One year of COVID-19 in the Netherlands—a Dutch narrative. J Crit Care 2021; 29:78–84
de Graaff MR, Hogenbirk RNM, Janssen YF, et al.; Dutch CovidSurg Collaborative Study Group: Impact of the COVID-19 pandemic on surgical care in the Netherlands. Br J Surg 2022; 109:1282–1292
Nederlandse Vereniging voor Intensive Care (NVIC): Checklist zorgbeleidsplan IC afdelingen in Nederland; 2021, p.1–8. Available at: https://www.nvic.nl/wp-content/uploads/2022/01/20210406-Blauwdruk-ZBP-NVIC-versie-2021.pdf. Accessed December 7, 2023
Hoogendoorn ME, Brinkman S, Bosman RJ, et al.: The impact of COVID-19 on nursing workload and planning of nursing staff on the intensive care: A prospective descriptive multicenter study. Int J Nurs Stud 2021; 121:104005
Hubner M, Zingg T, Martin D, et al.: Surgery for non-COVID-19 patients during the pandemic. PLoS One 2020; 15:e0241331
Shao CC, McLeod MC, Gleason L, et al.: Effect of COVID-19 pandemic restructuring on surgical volume and outcomes of non-COVID patients undergoing surgery. Am Surg 2022; 88:489–497
Wartelle A, Mourad-Chehade F, Yalaoui F, et al.: Effect of the COVID-19 pandemic lockdown on non-COVID-19 emergency department visits in Eastern France: Reduced risk or avoidance behavior? Public Health Pract (Oxf) 2021; 2:100109
Barten DG, Latten GHP, van Osch FHM: Reduced emergency department utilization during the early phase of the COVID-19 pandemic: Viral fear or lockdown effect? Disaster Med Public Health Prep 2022; 16:36–39
Moynihan R, Sanders S, Michaleff ZA, et al.: Impact of COVID-19 pandemic on utilisation of healthcare services: A systematic review. BMJ Open 2021; 11:e045343
Tandon T, Dubey AK, Dubey S, et al.: Effects of COVID-19 pandemic lockdown on medical advice seeking and medication practices of home-bound non-COVID patients. J Educ Health Promot 2021; 10:28
Bodilsen J, Nielsen PB, Sogaard M, et al.: Hospital admission and mortality rates for non-covid diseases in Denmark during COVID-19 pandemic: Nationwide population based cohort study. BMJ (Clin Res Ed) 2021; 373:n1135
Appleby J: What is happening to non-covid deaths? BMJ (Clin Res Ed) 2020; 369:m1607
NICE: National Intensive Care Evaluation (NICE) 2023. Available at: https://www.stichting-nice.nl/watweregistreren.jsp. Accessed 2023
Zimmerman JE, Kramer AA, McNair DS, et al.: Acute Physiology and Chronic Health Evaluation (APACHE) IV: Hospital mortality assessment for today’s critically ill patients. Crit Care Med 2006; 34:1297–1310
Knaus WA, Wagner DP, Draper EA, et al.: The APACHE III prognostic system risk prediction of hospital mortality for critically ill hospitalized adults. Chest 1991; 100:1619–1636
Expert Panel on the Identification, Evaluation, and Treatment of Overweight in Adults; Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: Executive summary. Am J Clin Nutr 1998; 68:899–917
Raknes G, Strom MS, Sulo G, et al.: Lockdown and non-COVID-19 deaths: Cause-specific mortality during the first wave of the 2020 pandemic in Norway: A population-based register study. BMJ Open 2021; 11:e050525
Tong SK, Ling L, Zhang JZ, et al.: Effect of the COVID-19 pandemic on cardiac arrest resuscitation practices and outcomes in non-COVID-19 patients. J Intensive Care 2021; 9:55
Unterberg M, Rahmel T, Rump K, et al.; SepsisDataNet.NRW research group: The impact of the COVID-19 pandemic on non-COVID induced sepsis survival. BMC Anesthesiol 2022; 22:12
Zampieri FG, Bastos LSL, Soares M, et al.: The association of the COVID-19 pandemic and short-term outcomes of non-COVID-19 critically ill patients: An observational cohort study in Brazilian ICUs. Intensive Care Med 2021; 47:1440–1449
Santi L, Golinelli D, Tampieri A, et al.: Non-COVID-19 patients in times of pandemic: Emergency department visits, hospitalizations and cause-specific mortality in Northern Italy. PLoS One 2021; 16:e0248995
Banerjee A, Chen S, Pasea L, et al.: Excess deaths in people with cardiovascular diseases during the COVID-19 pandemic. Eur J Prev Cardiol 2021; 28:1599–1609
COVIDSurg Collaborative: Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: An international, prospective, cohort study. Lancet Oncol 2021; 22:1507–1517
Rosell Ortiz F, Fernandez Del Valle P, Knox EC, et al.; OHSCAR investigators: Influence of the COVID-19 pandemic on out-of-hospital cardiac arrest A Spanish nationwide prospective cohort study. Resuscitation 2020; 157:230–240
COVID-19 mortality working group: Excess mortality continues in August 2022. Actuaries Digit 2022. Available at: https://www.actuaries.digital/2022/12/07/covid-19-mortality-working-group-excess-mortality-continues-in-august-2022/. Accessed December 7, 2023
McAlister FA, Chu A, Qiu F, et al.; CORONA Collaboration: Outcomes among patients hospitalized with non-COVID-19 conditions before and during the COVID-19 pandemic in Alberta and Ontario, Canada. JAMA Netw Open 2023; 6:e2323035
Federatie Medisch Specialisten en KNMG: Draaiboek Triage op basis van niet-medische overwegingen voor IC-opname ten tijde van fase 3 in de COVID-19 pandemie 2020. Available at: https://open.overheid.nl/documenten/ronl-9d9f1dd1-a35e-466e-9358-23ed72768994/pdf. Accessed December 7, 2023
Arunachala S, Venkatesh BT, Tusharbhai Bhatt M, et al.: COVID-19 pandemic: Impact on admission, diagnosis, and treatment of non-COVID-19 patients admitted to SARI ICU. Indian J Crit Care Med 2021; 25:853–859
Arsenault C, Gage A, Kim MK, et al.: COVID-19 and resilience of healthcare systems in ten countries. Nat Med 2022; 28:1314–1324
Anesi GL, Savarimuthu SM, Invernizzi J, et al.: ICU mortality across prepandemic and pandemic cohorts in a resource-limited setting: A critical care resiliency analysis from South Africa. CHEST Crit Care 2023; 1
Nielsen L: Pandemic prioritarianism. J Med Ethics 2022; 48:236–239
Anesi GL, Andrews A, Bai HJ, et al.; Severe Acute Respiratory Infection-Preparedness (SARI-PREP) Study Group: Perceived hospital stress, severe acute respiratory syndrome coronavirus 2 activity, and care process temporal variance during the COVID-19 pandemic. Crit Care Med 2023; 51:445–459
Wilcox ME, Rowan KM, Harrison DA, et al.: Does unprecedented ICU capacity strain, as experienced during the COVID-19 pandemic, impact patient outcome? Crit Care Med 2022; 50:e548–e556
Kadri SS, Sun J, Lawandi A, et al.: Association between caseload surge and COVID-19 survival in 558 US hospitals, March to August 2020. Ann Intern Med 2021; 174:1240–1251
Payet C, Polazzi S, Rimmelé T, et al.: Mortality among noncoronavirus disease 2019 critically ill patients attributable to the pandemic in France. Crit Care Med 2022; 50:138–143
Jeitziner MM, Moser A, Wendel-Garcia PD, et al.; RISC-19-ICU Investigators for Switzerland: Critical care staffing ratio and outcome of COVID-19 patients requiring intensive care unit admission during the first pandemic wave: A retrospective analysis across Switzerland from the RISC-19-ICU observational cohort. Swiss Med Wkly 2022; 152:w30183
Doidge JC, Gould DW, Ferrando-Vivas P, et al.: Trends in intensive care for patients with COVID-19 in England, Wales, and Northern Ireland. Am J Respir Crit Care Med 2021; 203:565–574

Auteurs

Sylvia Brinkman (S)

Department of Medical Informatics, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.
National Intensive Care Evaluation Foundation, Amsterdam, The Netherlands.
Amsterdam Public Health, Quality of Care, Amsterdam, The Netherlands.
University Medical Center, University of Utrecht, Intensive Care Medicine, Utrecht, The Netherlands.
Amsterdam UMC Location University of Amsterdam, Intensive Care Medicine, Amsterdam, The Netherlands.
Department of Intensive Care Medicine, Maastricht University Medical Centre +, Maastricht, The Netherlands.
Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.

Nicolette F de Keizer (NF)

Department of Medical Informatics, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.
National Intensive Care Evaluation Foundation, Amsterdam, The Netherlands.
Amsterdam Public Health, Quality of Care, Amsterdam, The Netherlands.
University Medical Center, University of Utrecht, Intensive Care Medicine, Utrecht, The Netherlands.
Amsterdam UMC Location University of Amsterdam, Intensive Care Medicine, Amsterdam, The Netherlands.
Department of Intensive Care Medicine, Maastricht University Medical Centre +, Maastricht, The Netherlands.
Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.

Dylan W de Lange (DW)

National Intensive Care Evaluation Foundation, Amsterdam, The Netherlands.
University Medical Center, University of Utrecht, Intensive Care Medicine, Utrecht, The Netherlands.

Dave A Dongelmans (DA)

National Intensive Care Evaluation Foundation, Amsterdam, The Netherlands.
Amsterdam Public Health, Quality of Care, Amsterdam, The Netherlands.
Amsterdam UMC Location University of Amsterdam, Intensive Care Medicine, Amsterdam, The Netherlands.

Fabian Termorshuizen (F)

Department of Medical Informatics, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.
National Intensive Care Evaluation Foundation, Amsterdam, The Netherlands.
Amsterdam Public Health, Quality of Care, Amsterdam, The Netherlands.
University Medical Center, University of Utrecht, Intensive Care Medicine, Utrecht, The Netherlands.
Amsterdam UMC Location University of Amsterdam, Intensive Care Medicine, Amsterdam, The Netherlands.
Department of Intensive Care Medicine, Maastricht University Medical Centre +, Maastricht, The Netherlands.
Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.

Bas C T van Bussel (BCT)

National Intensive Care Evaluation Foundation, Amsterdam, The Netherlands.
Department of Intensive Care Medicine, Maastricht University Medical Centre +, Maastricht, The Netherlands.
Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.

Classifications MeSH