Male breast cancer: No evidence for mosaic BRCA1 promoter methylation involvement.
Breast neoplasm
DNA methylation
Epigenomics
Genetic testing
HBOC syndrome
Homologous recombination
Journal
Breast (Edinburgh, Scotland)
ISSN: 1532-3080
Titre abrégé: Breast
Pays: Netherlands
ID NLM: 9213011
Informations de publication
Date de publication:
10 Dec 2023
10 Dec 2023
Historique:
received:
17
11
2023
revised:
05
12
2023
accepted:
07
12
2023
medline:
15
12
2023
pubmed:
15
12
2023
entrez:
14
12
2023
Statut:
aheadofprint
Résumé
Breast cancers (BC) are rare in men and are often caused by constitutional predisposing factors. In women, mosaic BRCA1 promoter methylations (MBPM) are frequent events, detected in 4-8% of healthy subjects. This constitutional epimutation increases risk of early-onset and triple-negative BC. However, the role of MBPM in male BC predisposition has never been assessed. We screened 40 blood samples from men affected by BC, and performed extensive tumour analysis on MBPM-positive patients. We detected two patients carrying MBPM. Surprisingly, tumour analysis revealed that neither of these two male BCs were caused by the constitutional BRCA1 epimutations carried by the patients.
Identifiants
pubmed: 38096711
pii: S0960-9776(23)00746-4
doi: 10.1016/j.breast.2023.103620
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103620Informations de copyright
Copyright © 2023. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflict of interest.