The Role of Exosomes in Upper-Extremity Tissue Regeneration.
Basic science
exosomes
regenerative medicine
tissue regeneration
upper extremity injuries
Journal
The Journal of hand surgery
ISSN: 1531-6564
Titre abrégé: J Hand Surg Am
Pays: United States
ID NLM: 7609631
Informations de publication
Date de publication:
13 Dec 2023
13 Dec 2023
Historique:
received:
02
05
2022
revised:
07
06
2023
accepted:
13
11
2023
medline:
15
12
2023
pubmed:
15
12
2023
entrez:
15
12
2023
Statut:
aheadofprint
Résumé
Exosomes are cell-free membrane vesicles secreted by a wide variety of cells as secretomes into the extracellular matrix. Alongside facilitating intercellular communication, exosomes carry various bioactive molecules consisting of nucleic acids, proteins, and lipids. Exosome applications have increased in popularity by overcoming the disadvantages of mesenchymal stem cell therapies. Despite this, a better understanding of the underlying mechanisms of action of exosomes is necessary prior to clinical application in upper-extremity tissue regeneration. The purpose of this review is to introduce the concept of exosomes and their possible applications in upper-extremity tissue regeneration, detail the shortcomings of current exosome research, and explore their potential clinical application in the upper extremity.
Identifiants
pubmed: 38099878
pii: S0363-5023(23)00617-2
doi: 10.1016/j.jhsa.2023.11.016
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.