A compartment model for subcutaneous injection of monoclonal antibodies.
Bioavailability
Compartment model
FcRn-expressing cells
Monoclonal antibodies
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
14 Dec 2023
14 Dec 2023
Historique:
received:
27
05
2023
revised:
01
12
2023
accepted:
06
12
2023
medline:
17
12
2023
pubmed:
17
12
2023
entrez:
16
12
2023
Statut:
aheadofprint
Résumé
Despite the growing popularity of subcutaneous (SC) administration for monoclonal antibodies (mAbs), there remains a limited understanding of the significance of mAb transport rate constants within the interstitial space and the lymphatic system on their pharmacokinetics. To bridge this knowledge gap, we introduce a compartmental model for subcutaneously administered mAbs. Our model differentiates FcRn-expressing cells across various sites, and the model predictions agree with experimental data from both human and rat studies. Our findings indicate that the time to reach the maximum mAb concentration in the plasma, denoted by T
Identifiants
pubmed: 38103705
pii: S0378-5173(23)01109-2
doi: 10.1016/j.ijpharm.2023.123687
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
123687Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest XZ and YL are research assistants, AMA is a professor in Mechanical Engineering at Purdue University.