Understanding Cr(III) Action on Mitochondrial ATP Synthase and AMPK Efficacy: Insights from Previous Studies-a Review.
Cr(III) action
Energy homeostasis
Glucose metabolism
Metabolic regulation
Nutrient transporters
Journal
Biological trace element research
ISSN: 1559-0720
Titre abrégé: Biol Trace Elem Res
Pays: United States
ID NLM: 7911509
Informations de publication
Date de publication:
18 Dec 2023
18 Dec 2023
Historique:
received:
09
09
2023
accepted:
08
12
2023
medline:
18
12
2023
pubmed:
18
12
2023
entrez:
17
12
2023
Statut:
aheadofprint
Résumé
Chromium supplementation has been notably recognized for its potential health benefits, especially in enhancing insulin sensitivity and managing glucose metabolism. However, recent studies have begun to shed light on additional mechanisms of action for chromium, expanding our understanding beyond its classical effects on the insulin-signaling pathway. The beta subunit of mitochondrial ATP synthase is considered a novel site for Cr(III) action, influencing physiological effects apart from insulin signaling. The physiological effects of chromium supplementation have been extensively studied, particularly in its role in anti-oxidative efficacy and glucose metabolism. However, recent advancements have prompted a re-evaluation of chromium's mechanisms of action beyond the insulin signaling pathway. The discovery of the beta subunit of mitochondrial ATP synthase as a potential target for chromium action is discussed, emphasizing its crucial role in cellular energy production and metabolic regulation. A meticulous analysis of relevant studies that were earlier carried out could shed light on the relationship between chromium supplementation and mitochondrial ATP synthase. This review categorizes studies based on their primary investigations, encompassing areas such as muscle protein synthesis, glucose and lipid metabolism, and antioxidant properties. Findings from these studies are scrutinized to distinguish patterns aligning with the new hypothesis. Central to this exploration is the presentation of studies highlighting the physiological effects of chromium that extend beyond the insulin signaling pathway. Evaluating the various independent mechanisms of action that chromium impacts cellular energy metabolism and overall metabolic balance has become more important. In conclusion, this review is a paradigm shift in understanding chromium supplementation, paving the way for future investigations that leverage the intricate interplay between chromium and mitochondrial ATP synthase.
Identifiants
pubmed: 38105318
doi: 10.1007/s12011-023-04010-6
pii: 10.1007/s12011-023-04010-6
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Hua Y, Clark S, Ren J, Sreejayan N (2012) Molecular mechanisms of chromium in alleviating ınsulin resistance. J Nutr Biochem 23:313–319. https://doi.org/10.1016/j.jnutbio.2011.11.001
doi: 10.1016/j.jnutbio.2011.11.001
pubmed: 22423897
pmcid: 3308119
Vincent JB (2015) Is the pharmacological mode of action of chromium(III) as a second messenger? Biol Trace Elem Res 166:7–12. https://doi.org/10.1007/s12011-015-0231-9
doi: 10.1007/s12011-015-0231-9
pubmed: 25595680
Anderson RA (2003) Chromium and insulin resistance. Nutr Res Rev 16:267–275. https://doi.org/10.1079/NRR200366
doi: 10.1079/NRR200366
pubmed: 19087394
Mertz W (1993) Chromium in human nutrition: a review. J Nutr 123:626–633. https://doi.org/10.1093/jn/123.4.626
doi: 10.1093/jn/123.4.626
pubmed: 8463863
Martin J, Wang ZQ, Zhang XH et al (2006) Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care 29:1826–1832. https://doi.org/10.2337/dc06-0254
doi: 10.2337/dc06-0254
pubmed: 16873787
Coates MPMCM, Paul MB, Blackman MR, Cragg GM, Levine M, White JD, Joel, (2013) Encyclopedia of Dietary Supplements (Online). CRC Press, Boca Raton
Costello RB, Dwyer JT, Bailey RL (2016) Chromium supplements for glycemic control in type 2 diabetes: limited evidence of effectiveness. Nutr Rev 74:455–468. https://doi.org/10.1093/nutrit/nuw011
doi: 10.1093/nutrit/nuw011
pubmed: 27261273
pmcid: 5009459
Wang H, Hu L, Li H et al (2023) Mitochondrial ATP synthase as a direct molecular target of chromium(III) to ameliorate hyperglycaemia stress. Nat Commun 14:1738. https://doi.org/10.1038/s41467-023-37351-w
doi: 10.1038/s41467-023-37351-w
pubmed: 36977671
pmcid: 10050403
DesMarais TL, Costa M (2019) Mechanisms of chromium-ınduced toxicity. Curr Opin Toxicol 14:1–7. https://doi.org/10.1016/j.cotox.2019.05.003
doi: 10.1016/j.cotox.2019.05.003
pubmed: 31511838
pmcid: 6737927
Khodavirdipour A, Haddadi F, Keshavarzi S (2020) Chromium supplementation; negotiation with diabetes mellitus, hyperlipidemia and depression. J Diabetes Metab Disord 19:585–595. https://doi.org/10.1007/s40200-020-00501-8
doi: 10.1007/s40200-020-00501-8
pubmed: 32550211
pmcid: 7270423
Sahin K, Kucuk O, Orhan C et al (2021) Effects of supplementing different chromium histidinate complexes on glucose and lipid metabolism and related protein expressions in rats fed a high-fat diet. J Trace Elem Med Biol 65:126723. https://doi.org/10.1016/j.jtemb.2021.126723
doi: 10.1016/j.jtemb.2021.126723
pubmed: 33508549
Sahin K, Tuzcu M, Orhan C et al (2012) The effects of chromium picolinate and chromium histidinate administration on NF-κB and Nrf2/HO-1 pathway in the brain of diabetic rats. Biol Trace Elem Res 150:291–296. https://doi.org/10.1007/s12011-012-9475-9
doi: 10.1007/s12011-012-9475-9
pubmed: 22790776
Orhan C, Kucuk O, Tuzcu M et al (2019) Effect of supplementing chromium histidinate and picolinate complexes along with biotin on insulin sensitivity and related metabolic indices in rats fed a high-fat diet. Food Sci Nutr 7:183–194. https://doi.org/10.1002/fsn3.851
doi: 10.1002/fsn3.851
pubmed: 30680172
Ulas M, Orhan C, Tuzcu M et al (2015) Anti-diabetic potential of chromium histidinate in diabetic retinopathy rats. BMC Complement Altern Med 15:16. https://doi.org/10.1186/s12906-015-0537-3
doi: 10.1186/s12906-015-0537-3
pubmed: 25652875
pmcid: 4321702
Vincent JB (2023) What Are the Implications of Cr(III) Serving as an ınhibitor of the beta subunit of mitochondrial ATP synthase? Biol Trace Elem Res. https://doi.org/10.1007/s12011-023-03809-7
doi: 10.1007/s12011-023-03809-7
pubmed: 37943387
pmcid: 10356904
Hoffman NJ, Penque BA, Habegger KM et al (2014) Chromium enhances insulin responsiveness via AMPK. J Nutr Biochem 25:565–572. https://doi.org/10.1016/j.jnutbio.2014.01.007
doi: 10.1016/j.jnutbio.2014.01.007
pubmed: 24725432
pmcid: 4030743
Orhan C, Tuzcu M, Deeh PBD et al (2019) Organic chromium form alleviates the detrimental effects of heat stress on nutrient digestibility and nutrient transporters in laying hens. Biol Trace Elem Res 189:529–537. https://doi.org/10.1007/s12011-018-1485-9
doi: 10.1007/s12011-018-1485-9
pubmed: 30132119
Sahin N, Hayirli A, Orhan C et al (2018) Effects of the supplemental chromium form on performance and metabolic profile in laying hens exposed to heat stress. Poult Sci 97:1298–1305. https://doi.org/10.3382/ps/pex435
doi: 10.3382/ps/pex435
pubmed: 29365168
Onderci M, Sahin N, Sahin K, Kilic N (2003) Antioxidant properties of chromium and zinc: in vivo effects on digestibility, lipid peroxidation, antioxidant vitamins, and some minerals under a low ambient temperature. Biol Trace Elem Res 92:139–150. https://doi.org/10.1385/BTER:92:2:139
doi: 10.1385/BTER:92:2:139
pubmed: 12746573
Turgut M, Cinar V, Pala R et al (2018) Biotin and chromium histidinate improve glucose metabolism and proteins expression levels of IRS-1, PPAR-γ, and NF-κB in exercise-trained rats. J Int Soc Sports Nutr 15:45. https://doi.org/10.1186/s12970-018-0249-4
doi: 10.1186/s12970-018-0249-4
pubmed: 30219082
pmcid: 6139124
Sahin K, Orhan C, Ozdemir O et al (2023) Effects of whey protein combined with amylopectin/chromium on the muscle protein synthesis and mTOR phosphorylation in exercised rats. Biol Trace Elem Res. https://doi.org/10.1007/s12011-023-03732-x
doi: 10.1007/s12011-023-03732-x
pubmed: 37872362
Ozdemir O, Erten F, Er B et al (2023) Evaluation of pea/rice and amylopectin/chromium as an alternative protein source to improve muscle protein synthesis in rats. Eur J Nutr 62:2293–2302. https://doi.org/10.1007/s00394-023-03150-8
doi: 10.1007/s00394-023-03150-8
pubmed: 37186279
Komorowski JR, Ojalvo SP, Sylla S et al (2020) The addition of an amylopectin/chromium complex to branched-chain amino acids enhances muscle protein synthesis in rat skeletal muscle. J Int Soc Sports Nutr 17:26. https://doi.org/10.1186/s12970-020-00355-8
doi: 10.1186/s12970-020-00355-8
pubmed: 32460884
pmcid: 7251890
Pala R, Sari MA, Erten F et al (2020) The effects of chromium picolinate on glucose and lipid metabolism in running rats. J Trace Elem Med Biol 58:126434. https://doi.org/10.1016/j.jtemb.2019.126434
doi: 10.1016/j.jtemb.2019.126434
pubmed: 31778961
Machac N, Kaya Karasu G, Sahin N et al (2019) Effects of supplementation of chromium histidinate on glucose, lipid metabolism and oxidative stress in cats. J Anim Physiol Anim Nutr (Berl) 103:331–338. https://doi.org/10.1111/jpn.13023
doi: 10.1111/jpn.13023
pubmed: 30467904
Selcuk MY, Aygen B, Dogukan A et al (2012) Chromium picolinate and chromium histidinate protects against renal dysfunction by modulation of NF-κB pathway in high-fat diet fed and Streptozotocin-induced diabetic rats. Nutr Metab (Lond) 9:30. https://doi.org/10.1186/1743-7075-9-30
doi: 10.1186/1743-7075-9-30
pubmed: 22483164
Tuzcu M, Sahin N, Orhan C et al (2011) Impact of chromium histidinate on high fat diet induced obesity in rats. Nutr Metab (Lond) 8:28. https://doi.org/10.1186/1743-7075-8-28
doi: 10.1186/1743-7075-8-28
pubmed: 21539728
Sahin K, Tuzcu M, Orhan C et al (2011) The effects of chromium complex and level on glucose metabolism and memory acquisition in rats fed high-fat diet. Biol Trace Elem Res 143:1018–1030. https://doi.org/10.1007/s12011-010-8905-9
doi: 10.1007/s12011-010-8905-9
pubmed: 21120707
Dogukan A, Tuzcu M, Juturu V et al (2010) Effects of chromium histidinate on renal function, oxidative stress, and heat-shock proteins in fat-fed and streptozotocin-treated rats. J Ren Nutr 20:112–120. https://doi.org/10.1053/j.jrn.2009.04.009
doi: 10.1053/j.jrn.2009.04.009
pubmed: 19616452
Dogukan A, Sahin N, Tuzcu M et al (2009) The effects of chromium histidinate on mineral status of serum and tissue in fat-fed and streptozotocin-treated type II diabetic rats. Biol Trace Elem Res 131:124–132. https://doi.org/10.1007/s12011-009-8351-8
doi: 10.1007/s12011-009-8351-8
pubmed: 19271160
Sahin K, Onderci M, Tuzcu M et al (2007) Effect of chromium on carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus: the fat-fed, streptozotocin-treated rat. Metabolism 56:1233–1240. https://doi.org/10.1016/j.metabol.2007.04.021
doi: 10.1016/j.metabol.2007.04.021
pubmed: 17697867
Sahin K, Onderci M, Sahin N et al (2004) Effects of dietary combination of chromium and biotin on egg production, serum metabolites, and egg yolk mineral and cholesterol concentrations in heat-distressed laying quails. Biol Trace Elem Res 101:181–192. https://doi.org/10.1385/BTER:101:2:181
doi: 10.1385/BTER:101:2:181
pubmed: 15557680
Sahin N, Sahin K, Onderci M et al (2003) In vivo antioxidant properties of vitamin E and chromium in cold-stressed Japanese quails. Arch Tierernahr 57:207–215. https://doi.org/10.1080/0003942031000136639
doi: 10.1080/0003942031000136639
pubmed: 12903865
Sahin K, Sahin N, Kucuk O (2002) Effects of dietary chromium and ascorbic acid supplementation on digestion of nutrients, serum antioxidant status, and mineral concentrations in laying hens reared at a low ambient temperature. Biol Trace Elem Res 87:113–124. https://doi.org/10.1385/BTER:87:1-3:113
doi: 10.1385/BTER:87:1-3:113
pubmed: 12117221
Sahin K, Ozbey O, Onderci M et al (2002) Chromium supplementation can alleviate negative effects of heat stress on egg production, egg quality and some serum metabolites of laying Japanese quail. J Nutr 132:1265–1268. https://doi.org/10.1093/jn/132.6.1265
doi: 10.1093/jn/132.6.1265
pubmed: 12042444
Sahin K, Küçük O, Sahin N (2001) Effects of dietary chromium picolinate supplementation on performance and plasma concentrations of insulin and corticosterone in laying hens under low ambient temperature. J Anim Physiol Anim Nutr (Berl) 85:142–147. https://doi.org/10.1046/j.1439-0396.2001.00314.x
doi: 10.1046/j.1439-0396.2001.00314.x
pubmed: 11686782
Kayri V, Orhan C, Tuzcu M et al (2019) Combination of soy protein, amylopectin, and chromium stimulates muscle protein synthesis by regulation of ubiquitin-proteasome proteolysis pathway after exercise. Biol Trace Elem Res 190:140–149. https://doi.org/10.1007/s12011-018-1539-z
doi: 10.1007/s12011-018-1539-z
pubmed: 30293129
Ozdemir O, Tuzcu M, Sahin N et al (2017) Organic chromium modifies the expression of orexin and glucose transporters of ovarian in heat-stressed laying hens. Cell Mol Biol (Noisy-le-grand) 63:93–98. https://doi.org/10.14715/cmb/2017.63.10.15
doi: 10.14715/cmb/2017.63.10.15
pubmed: 29096748
Sahin N, Hayirli A, Orhan C et al (2017) Effects of the supplemental chromium form on performance and oxidative stress in broilers exposed to heat stress. Poult Sci 96:4317–4324. https://doi.org/10.3382/ps/pex249
doi: 10.3382/ps/pex249
pubmed: 29053811
Sahin K, Tuzcu M, Orhan C et al (2013) Anti-diabetic activity of chromium picolinate and biotin in rats with type 2 diabetes induced by high-fat diet and streptozotocin. Br J Nutr 110:197–205. https://doi.org/10.1017/S0007114512004850
doi: 10.1017/S0007114512004850
pubmed: 23211098
Sahin N, Sahin K, Onderci M et al (2005) Chromium picolinate, rather than biotin, alleviates performance and metabolic parameters in heat-stressed quail. Br Poult Sci 46:457–463. https://doi.org/10.1080/00071660500190918
doi: 10.1080/00071660500190918
pubmed: 16268103
Onderci M, Sahin K, Sahin N et al (2005) Effects of dietary combination of chromium and biotin on growth performance, carcass characteristics, and oxidative stress markers in heat-distressed Japanese quail. Biol Trace Elem Res 106:165–176. https://doi.org/10.1385/BTER:106:2:165
doi: 10.1385/BTER:106:2:165
pubmed: 16116248
Sahin K, Sahin N, Onderci M et al (2002) Optimal dietary concentration of chromium for alleviating the effect of heat stress on growth, carcass qualities, and some serum metabolites of broiler chickens. Biol Trace Elem Res 89:53–64. https://doi.org/10.1385/BTER:89:1:53
doi: 10.1385/BTER:89:1:53
pubmed: 12413051
Sahin K, Onderci M, Sahin N, Aydin S (2002) Effects of dietary chromium picolinate and ascorbic acid supplementation on egg production, egg quality and some serum metabolites of laying hens reared under a low ambient temperature (6 degrees C). Arch Tierernahr 56:41–49. https://doi.org/10.1080/00039420214174
doi: 10.1080/00039420214174
pubmed: 12389221
Sahin N, Onderci M, Sahin K (2002) Effects of dietary chromium and zinc on egg production, egg quality, and some blood metabolites of laying hens reared under low ambient temperature. Biol Trace Elem Res 85:47–58. https://doi.org/10.1385/BTER:85:1:47
doi: 10.1385/BTER:85:1:47
pubmed: 11881798
Sahin K, Tuzcu M, Orhan C et al (2013) Chromium modulates expressions of neuronal plasticity markers and glial fibrillary acidic proteins in hypoglycemia-induced brain injury. Life Sci 93:1039–1048. https://doi.org/10.1016/j.lfs.2013.10.009
doi: 10.1016/j.lfs.2013.10.009
pubmed: 24157456
Sahin N, Akdemir F, Orhan C et al (2012) A novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed rats. Nutr Neurosci 15:42–47. https://doi.org/10.1179/1476830512Y.0000000018
doi: 10.1179/1476830512Y.0000000018
pubmed: 23232054
Thirunavukkarasu M, Penumathsa S, Juhasz B et al (2006) Enhanced cardiovascular function and energy level by a novel chromium (III)-supplement. BioFactors 27:53–67. https://doi.org/10.1002/biof.5520270106
doi: 10.1002/biof.5520270106
pubmed: 17012764
Zhao P, Wang J, Ma H et al (2009) A newly synthetic chromium complex-chromium (D-phenylalanine)3 activates AMP-activated protein kinase and stimulates glucose transport. Biochem Pharmacol 77:1002–1010. https://doi.org/10.1016/j.bcp.2008.11.018
doi: 10.1016/j.bcp.2008.11.018
pubmed: 19073152
Penumathsa SV, Thirunavukkarasu M, Samuel SM et al (2009) Niacin bound chromium treatment induces myocardial Glut-4 translocation and caveolar interaction via Akt, AMPK and eNOS phosphorylation in streptozotocin-induced diabetic rats after ischemia-reperfusion injury. Biochim Biophys Acta 1792:39–48. https://doi.org/10.1016/j.bbadis.2008.10.018
doi: 10.1016/j.bbadis.2008.10.018
pubmed: 19027847
Wang Y-Q, Dong Y, Yao M-H (2009) Chromium picolinate inhibits resistin secretion in insulin-resistant 3T3-L1 adipocytes via activation of amp-activated protein kinase. Clin Exp Pharmacol Physiol 36:843–849. https://doi.org/10.1111/j.1440-1681.2009.05164.x
doi: 10.1111/j.1440-1681.2009.05164.x
pubmed: 19298540
Sealls W, Penque BA, Elmendorf JS (2011) Evidence that chromium modulates cellular cholesterol homeostasis and ABCA1 functionality impaired by hyperinsulinemia–brief report. Arterioscler Thromb Vasc Biol 31:1139–1140. https://doi.org/10.1161/ATVBAHA.110.222158
doi: 10.1161/ATVBAHA.110.222158
pubmed: 21311039
pmcid: 3081388
Hao J, Hao C, Zhang L et al (2015) OM2, a novel oligomannuronate-chromium(III) complex, promotes mitochondrial biogenesis and lipid metabolism in 3T3-L1 adipocytes via the AMPK-PGC1α pathway. PLoS ONE 10:e0131930. https://doi.org/10.1371/journal.pone.0131930
doi: 10.1371/journal.pone.0131930
pubmed: 26176781
pmcid: 4503612
Liu L, Wang B, He Y et al (2017) Effects of chromium-loaded chitosan nanoparticles on glucose transporter 4, relevant mRNA, and proteins of phosphatidylinositol 3-kinase, Akt2-kinase, and AMP-activated protein kinase of skeletal muscles in finishing pigs. Biol Trace Elem Res 178:36–43. https://doi.org/10.1007/s12011-016-0890-1
doi: 10.1007/s12011-016-0890-1
pubmed: 27888450
Zhang W, Chen H, Ding Y et al (2020) Effect of chromium citrate on the mechanism of glucose transport and insulin resistance in Buffalo rat liver cells. Indian J Pharmacol 52:31–38. https://doi.org/10.4103/ijp.IJP_608_18
doi: 10.4103/ijp.IJP_608_18
pubmed: 32201444
pmcid: 7074430
Kim J, Chung K, Johnson BJ (2020) Chromium acetate stimulates adipogenesis through regulation of gene expression and phosphorylation of adenosine monophosphate-activated protein kinase in bovine intramuscular or subcutaneous adipocytes. Asian-Australas J Anim Sci 33:651–661. https://doi.org/10.5713/ajas.19.0089
doi: 10.5713/ajas.19.0089
pubmed: 31480166
Zhang W, Li L, Ma Y et al (2022) Structural characterization and hypoglycemic activity of a novel pumpkin peel polysaccharide-chromium(III) complex. Foods 11:1821. https://doi.org/10.3390/foods11131821
doi: 10.3390/foods11131821
pubmed: 35804640
pmcid: 9265534