Detection of Duffy Blood Group Genotypes and Submicroscopic Plasmodium Infections Using Molecular Diagnostic Assays in Febrile Malaria Patients.
Duffy genotype
Ethiopia
Malaria
Microscopy
Plasmodium falciparum
Plasmodium vivax
Quantitative PCR
submicroscopic Plasmodium infection
Journal
Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035
Informations de publication
Date de publication:
06 Dec 2023
06 Dec 2023
Historique:
pubmed:
18
12
2023
medline:
18
12
2023
entrez:
18
12
2023
Statut:
epublish
Résumé
Malaria remains a severe parasitic disease, posing a significant threat to public health and hindering economic development in sub-Saharan Africa. Ethiopia, a malaria endemic country, is facing a resurgence of the disease with a steadily rising incidence. Conventional diagnostic methods, such asmicroscopy, have become less effective due to low parasite density, particularly among Duffy-negative human populations in Africa. To develop comprehensive control strategies, it is crucial to generate data on the distribution and clinical occurrence of Three hundred febrile patients visiting four health facilities in Jimma town of southwestern Ethiopia were randomly selected during the malaria transmission season (Apr-Oct). Sociodemographic information was collected, and microscopic examination was performed for all study participants. The The present study revealed a high prevalence of submicroscopic malaria infections.
Sections du résumé
Background
UNASSIGNED
Malaria remains a severe parasitic disease, posing a significant threat to public health and hindering economic development in sub-Saharan Africa. Ethiopia, a malaria endemic country, is facing a resurgence of the disease with a steadily rising incidence. Conventional diagnostic methods, such asmicroscopy, have become less effective due to low parasite density, particularly among Duffy-negative human populations in Africa. To develop comprehensive control strategies, it is crucial to generate data on the distribution and clinical occurrence of
Methods
UNASSIGNED
Three hundred febrile patients visiting four health facilities in Jimma town of southwestern Ethiopia were randomly selected during the malaria transmission season (Apr-Oct). Sociodemographic information was collected, and microscopic examination was performed for all study participants.
Results
UNASSIGNED
The
Conclusions
UNASSIGNED
The present study revealed a high prevalence of submicroscopic malaria infections.
Identifiants
pubmed: 38105972
doi: 10.21203/rs.3.rs-3706814/v1
pmc: PMC10723540
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI162947
Pays : United States
Déclaration de conflit d'intérêts
Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nat Commun. 2019 Dec 6;10(1):5595
pubmed: 31811128
Lancet. 2015 Oct 3;386(10001):1314-1317
pubmed: 26460761
Biometrics. 2020 Dec;76(4):1351-1363
pubmed: 32022247
PLoS One. 2015 Feb 12;10(2):e0117229
pubmed: 25675342
Health Res Policy Syst. 2009 Dec 13;7:29
pubmed: 20003381
Mol Ther Methods Clin Dev. 2022 Aug 02;26:427-440
pubmed: 36092359
Lancet Infect Dis. 2012 Jun;12(6):488-96
pubmed: 22632187
N Engl J Med. 1976 Aug 5;295(6):302-4
pubmed: 778616
Elife. 2017 Dec 07;6:
pubmed: 29215331
Am J Trop Med Hyg. 2018 Nov;99(5):1128-1133
pubmed: 30203741
Malar J. 2018 Feb 05;17(1):67
pubmed: 29402282
Trends Parasitol. 2014 Apr;30(4):183-90
pubmed: 24642035
Malar J. 2020 Aug 24;19(1):299
pubmed: 32831093
Nature. 2008 Oct 9;455(7214):757-63
pubmed: 18843361
Microorganisms. 2020 Dec 23;9(1):
pubmed: 33374596
PLoS Negl Trop Dis. 2011 Jun;5(6):e1192
pubmed: 21713024
Science. 1975 Aug 15;189(4202):561-3
pubmed: 1145213
Rev Med Suisse. 2021 Mar 17;17(730):521-523
pubmed: 33755360
Br J Haematol. 1977 Jul;36(3):327-35
pubmed: 70210
Biotechniques. 1991 Apr;10(4):506-13
pubmed: 1867860
Am J Trop Med Hyg. 2007 Oct;77(4):623-6
pubmed: 17978060
Malar J. 2011 Oct 11;10:297
pubmed: 21989376
Blood Cells Mol Dis. 2009 May-Jun;42(3):267-78
pubmed: 19233695
Nat Commun. 2011;2:266
pubmed: 21468018
Front Trop Dis. 2022;3:
pubmed: 36619004
PLoS One. 2012;7(9):e45219
pubmed: 23028857
Korean J Parasitol. 2019 Jun;57(3):233-242
pubmed: 31284345
Emerg Infect Dis. 2007 Jan;13(1):140-3
pubmed: 17370530
Rev Bras Hematol Hemoter. 2011;33(1):55-64
pubmed: 23284245
Trans R Soc Trop Med Hyg. 2000 Jan-Feb;94(1):17-21
pubmed: 10748890
PLoS One. 2014 Aug 01;9(8):e103262
pubmed: 25084090
Mol Biol Evol. 2002 Oct;19(10):1802-6
pubmed: 12270907
Malar J. 2015 May 15;14:201
pubmed: 25971594
Parasitology. 2016 Aug;143(9):1187-92
pubmed: 27045365
Trans R Soc Trop Med Hyg. 2013 May;107(5):328-31
pubmed: 23584375
East Afr Med J. 2005 Apr;82(4):186-92
pubmed: 16122086
Proc Biol Sci. 2014 Aug 22;281(1789):20140930
pubmed: 24990677
Lancet Infect Dis. 2021 Jan;21(1):59-69
pubmed: 32971006
Osong Public Health Res Perspect. 2014 Dec;5(6):351-7
pubmed: 25562044
Cell Host Microbe. 2015 Apr 8;17(4):526-35
pubmed: 25800544
Sci Rep. 2022 Mar 7;12(1):3998
pubmed: 35256675
Malar J. 2015 Feb 19;14:84
pubmed: 25884875
Mol Biochem Parasitol. 1993 Oct;61(2):315-20
pubmed: 8264734
J Clin Microbiol. 2006 Mar;44(3):1087-9
pubmed: 16517900
Am J Trop Med Hyg. 2009 Jan;80(1):103-11
pubmed: 19141847