Chronic Myelomonocytic Leukemia Patients With Lysozyme Nephropathy and Renal Infiltration Display Markers of Severe Disease.

acute kidney injury chronic myelomonocytic leukemia

Journal

Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752

Informations de publication

Date de publication:
Dec 2023
Historique:
received: 30 06 2023
revised: 29 08 2023
accepted: 04 09 2023
medline: 18 12 2023
pubmed: 18 12 2023
entrez: 18 12 2023
Statut: epublish

Résumé

Chronic myelomonocytic leukemia (CMML) is a hematologic disorder that is an overlap syndrome between myelodysplastic syndromes and myeloproliferative neoplasms, and can be associated with autoimmune and inflammatory diseases. This study aimed to describe kidney involvement in patients with CMML, their treatments, and outcomes. We conducted a French and American multicenter retrospective study in 15 centers, identifying patients with CMML with acute kidney injury (AKI), chronic kidney disease (CKD), and urine abnormalities. Sixteen patients (males, In this cohort of patients with CMML with a kidney injury, the 2 most frequent renal complications were lysozyme-induced nephropathy and renal infiltration by the CMML. Kidney involvement should be closely monitored in patients with CMML.

Identifiants

DOI: 10.1016/j.ekir.2023.09.005 PMID: 38106568 PMC: PMC10719588
pubmed: 38106568
doi: 10.1016/j.ekir.2023.09.005
pii: S2468-0249(23)01482-1
pmc: PMC10719588
doi:

Types de publication

Journal Article

Langues

eng

Pagination

2733-2741

Investigateurs

Marie-Camille Lafargue (MC)
Mickaël Bobot (M)
Thibault Comont (T)
Nathalie Cambier (N)
Kamel Laribi (K)
Olivier Fain (O)
Lionel Adès (L)
Pierre Fenaux (P)
Arsène Mekinian (A)
Thibault Comont (T)
Nathalie Cambier (N)
Kamel Laribi (K)
Olivier Fain (O)
Lionel Adès (L)
Pierre Fenaux (P)
Arsène Mekinian (A)
Thibault Comont (T)
Olivier Fain (O)
Lionel Adès (L)
Pierre Fenaux (P)
Arsène Mekinian (A)

Informations de copyright

© 2023 International Society of Nephrology. Published by Elsevier Inc.

Auteurs

Marie-Camille Lafargue (MC)

Department of Nephrology, Tenon's Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France.

Mickaël Bobot (M)

Centre de Néphrologie et Transplantation Rénale, AP-HM, Hôpital de la Conception, CHU de la Conception, 13005, Marseille, France.

Helmut G Rennke (HG)

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Marie Essig (M)

Department of Nephrology, Assistance Publique-Hôpitaux de Paris, Hôpital Ambroise Paré, Boulogne-Billancourt, Université Paris-Saclay, Paris, France.

Martin Carre (M)

Service d'Hématologie, Centre Hospitalier Universitaire, Grenoble, France.

Lucile Mercadal (L)

Department of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Paris, Hôpital de La Pitié Salpêtrière, Paris, France.

Jonathan Farhi (J)

Maladies du Sang, CHU d'Angers, 49000 Angers, France.

Hamza Sakhi (H)

Department of Nephrology and renal transplantation, Necker's Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France.

Thibault Comont (T)

Department of Internal Medicine, Institut universitaire du cancer de Toulouse, Centre Hospitalier Universitaire de Toulouse, Université Toulouse III - Paul Sabatier, Toulouse, France.

Léonard Golbin (L)

Service de Néphrologie, Dialyse et Transplantation Rénale, CHU Rennes, Hôpital Pontchaillou, Rennes, France.

Pierre Isnard (P)

Department of Pathology, Université Paris Cité, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

Jonathan Chemouny (J)

Hématologie Clinique, Centre Hospitalier de Valenciennes, Valenciennes, France.

Nathalie Cambier (N)

Department of Haematology, Centre Hospitalier Le Mans, France.

Kamel Laribi (K)

Centre Hospitalier Le Mans, Le Mans, France.

Umut Selamet (U)

Division of Renal Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Leonardo V Riella (LV)

Center of Transplantation Sciences, Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.

Olivier Fain (O)

Hôpital Saint-Antoine, Service de Médecine Interne et de l'Inflammation-(DHU i2B), F-75012, Assistance Publique-Hôpitaux de Paris, Paris, France.

Lionel Adès (L)

Hématologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Paris, France.

Pierre Fenaux (P)

Hématologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Paris, France.

Camille Cohen (C)

INSERM U1151 « mechanisms and therapeutic strategies of chronic kidney diseases », Hôpital Necker, Université Paris Cité, Paris, France; Service de Néphrologie et Transplantation rénale, Assistance Publique-Hôpitaux de Paris, Hôpital Necker, Paris, France.

Arsène Mekinian (A)

Hôpital Saint-Antoine, Service de Médecine Interne et de l'Inflammation-(DHU i2B), F-75012, Assistance Publique-Hôpitaux de Paris, Paris, France.

Classifications MeSH