[Thermoneutrality and animal study].
Thermoneutralité chez la souris et expérimentation animale.
Journal
Medecine sciences : M/S
ISSN: 1958-5381
Titre abrégé: Med Sci (Paris)
Pays: France
ID NLM: 8710980
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
medline:
18
12
2023
pubmed:
18
12
2023
entrez:
18
12
2023
Statut:
ppublish
Résumé
Animal models remain important for the study of human pathologies. The most widely used model (mouse) is an endothermic mammal like humans, maintained at ambient temperatures (22 °C). Its energy metabolism is overactivated, a situation rarely observed in humans thanks to various adaptations (clothing, heating…). The thermoneutral zone is defined as a range of ambient temperatures that allows an organism to regulate body temperature without using additional thermoregulatory processes. There are many examples of divergent results between studies conducted at 22 °C or at 30 °C (thermoneutrality for mice). Therefore, it seems essential to take into account the housing temperature both for animal welfare and for the relevance of the results. Thermoneutralité chez la souris et expérimentation animale. Les modèles animaux demeurent une nécessité pour l’étude des maladies humaines. Le modèle le plus utilisé, la souris, est, comme les êtres humains, un mammifère endotherme maintenu à des températures ambiantes (22 °C). Son métabolisme énergétique est donc suractivé, une situation rarement observée chez les êtres humains grâce à diverses adaptations (vêtements, chauffage, etc.). La zone de thermoneutralité est définie comme une plage de températures ambiantes qui permet à un organisme de réguler sa température corporelle sans recourir à des processus de thermorégulation supplémentaires. Il existe de nombreux exemples de résultats divergents entre des études menées à 22 °C et celles réalisées à 30 °C (thermoneutralité chez la souris). Il semble donc essentiel de prendre en compte la température d’hébergement tant pour le bien-être animal que pour la pertinence des résultats des expériences réalisées.
Autres résumés
Type: Publisher
(fre)
Thermoneutralité chez la souris et expérimentation animale.
Identifiants
pubmed: 38108724
doi: 10.1051/medsci/2023176
pii: msc230166
doi:
Types de publication
English Abstract
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
937-944Subventions
Organisme : ANR
ID : ANR-17-CE14-0015
Informations de copyright
© 2023 médecine/sciences – Inserm.
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