Effects of acute beetroot juice and sodium nitrate on selected blood metabolites and response to transient ischemia: A crossover randomized clinical trial.
NADH
endothelial function
mitochondrial function
trimethylamine N-oxide
Journal
The Journal of nutrition
ISSN: 1541-6100
Titre abrégé: J Nutr
Pays: United States
ID NLM: 0404243
Informations de publication
Date de publication:
16 Dec 2023
16 Dec 2023
Historique:
received:
13
09
2023
revised:
07
12
2023
accepted:
13
12
2023
medline:
19
12
2023
pubmed:
19
12
2023
entrez:
18
12
2023
Statut:
aheadofprint
Résumé
Modification of the nitrate (NO The primary aim of the current study was to evaluate the plasma changes in betaine, choline, trimethylamine (TMA), TMA N-oxide (TMAO), and NO In a randomized crossover trial, eight healthy young adults ingested 800 mg NO Plasma betaine and choline levels peaked at 1 h after BRJ ingestion, and remained significantly higher than baseline values at all time points (p < 0.001 and p < 0.001, compared to pre-ingestion values). Over time, BRJ was more effective in increasing NOx compared with NIT (fixed trial effect p < 0.001). Baseline fluorescence decreased after both NIT and BRJ consumption (fixed time effect p = 0.005). Transient ischemia and reperfusion response increased because of NO Acute ingestion of BRJ elevated plasma betaine and choline, but not TMA and TMAO. Moreover, plasma NOx levels were higher in the BRJ trial than in the NIT trial. Various sources of NO Registered at the ClinicalTrials.gov (NCT05004935).
Sections du résumé
BACKGROUND
BACKGROUND
Modification of the nitrate (NO
OBJECTIVE
OBJECTIVE
The primary aim of the current study was to evaluate the plasma changes in betaine, choline, trimethylamine (TMA), TMA N-oxide (TMAO), and NO
METHODS
METHODS
In a randomized crossover trial, eight healthy young adults ingested 800 mg NO
RESULTS
RESULTS
Plasma betaine and choline levels peaked at 1 h after BRJ ingestion, and remained significantly higher than baseline values at all time points (p < 0.001 and p < 0.001, compared to pre-ingestion values). Over time, BRJ was more effective in increasing NOx compared with NIT (fixed trial effect p < 0.001). Baseline fluorescence decreased after both NIT and BRJ consumption (fixed time effect p = 0.005). Transient ischemia and reperfusion response increased because of NO
CONCLUSIONS
CONCLUSIONS
Acute ingestion of BRJ elevated plasma betaine and choline, but not TMA and TMAO. Moreover, plasma NOx levels were higher in the BRJ trial than in the NIT trial. Various sources of NO
TRIAL REGISTRATION
BACKGROUND
Registered at the ClinicalTrials.gov (NCT05004935).
Identifiants
pubmed: 38110180
pii: S0022-3166(23)72807-1
doi: 10.1016/j.tjnut.2023.12.018
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT05004935']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023. Published by Elsevier Inc.